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  1. Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenyan Women Diagnosed with Breast Cancer

    1. Michael Kitoi
    2. John Gitau
    3. Godfrey Wagutu
    4. Kennedy Mwangi
    5. Florence Ngonga
    6. Francis Makokha

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on the mutational and expression profile of ZNF217, ZNF750, ZNF703 Zinc finger genes in Kenya women with BCs. The evidence supporting the claims of the authors is solid. The work will be of interest to scientists or clinicians working in the field of diagnosis and detection for breast cancer.

    Reviewed by eLife

    13 evaluationsAppears in 1 listLatest version Latest activity

  3. Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity

    1. Karla M Castro
    2. Reyhaneh Ayardulabi
    3. Sarah Wehrle
    4. Hongrui Cui
    5. Sandrine Georgeon
    6. Joseph Schmidt
    7. Shuhao Xiao
    8. Nishat Seraj
    9. Wayne Harshbarger
    10. Corey P Mallett
    11. Ventzislav Vassilev
    12. Xavier Saelens
    13. Bruno E Correia

    • Curated by eLife

      eLife Assessment

      This important study presents a thoughtful design and characterization of chimeric influenza hemagglutinin (HA) head domains combining elements of distinct receptor-binding sites. The results provide convincing evidence that polyclonal cross-group responses to influenza A virus can be elicited by a single immunization. While the mechanistic basis of heterotrimer formation and immunodominance differences remains unclear, the authors provide new insights for protein design, vaccinology, and computational vaccine design.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease

    1. Alyssa C Parker
    2. J Brett Heimlich
    3. Joseph C Van Amburg
    4. Yash Pershad
    5. David A Ong
    6. Nicole A Mickels
    7. Laventa M Obare
    8. Ketan J Hoey
    9. Hannah K Giannini
    10. Ayesha Ahmad
    11. Caitlyn Vlasschaert
    12. Tarak N Nandi
    13. Ravi K Madduri
    14. Samuel S Bailin
    15. John R Koethe
    16. Celestine N Wanjalla
    17. Alexander G Bick

    • Curated by eLife

      eLife Assessment

      Clonal hematopoiesis of indeterminate potential (CHIP) is a known risk factor for coronary artery disease, though its precise role in disease progression continues to emerge. This study leverages valuable single-cell RNA data from patients with CHIP mutations and controls to predict key interactions between endothelial cells and monocytes. Using an AI prediction model, the authors identify druggable targets that mediate immune cell interactions in CHIP and provide solid evidence to support their findings.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  8. Where is the melody? Spontaneous attention orchestrates melody formation during polyphonic music listening

    1. Martin M Winchester
    2. Kevin Reynolds
    3. Charbel Nebo
    4. Ian Cecil Scott
    5. Giovanni M Di Liberto

    • Curated by eLife

      eLife Assessment

      This valuable work potentially advances our understanding of melody extraction in polyphonic music listening by identifying spontaneous attentional focus in uninstructed listening contexts. However, the evidence supporting the main conclusions is incomplete. The work will be of interest to psychologists and neuroscientists working on music listening, attention, and perception in ecological settings.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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