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  1. vassi – verifiable, automated scoring of social interactions in animal groups

    1. Paul Nührenberg
    2. Aneesh PH Bose
    3. Alex Jordan

    • Curated by eLife

      eLife Assessment

      This study presents vassi, a Python package that streamlines the preparation of training data for machine-learning-based classification of social behaviors in animal groups. This package is a valuable resource for researchers with computational expertise, implementing a framework for the detection of directed social interactions within a group and an interactive tool for reviewing and correcting behavior detections. However, the strength of evidence that the method is widely applicable remains incomplete, performance on benchmark dyadic datasets is comparable to existing approaches, and performance scores on collective behavioral datasets are low. While the package can analyze behavior in large groups of animals, it only outputs dyadic interactions within these groups and does not account for behaviors where more than two animals may be interacting.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Abnormal shear stress induces ferroptosis in endothelial cells via KLF6 downregulation

    1. Jingang Cui
    2. Zhiyu Fan
    3. Suoqi Ding
    4. Jiazhen Zhang
    5. Huihong Shen
    6. Syeda Armana Zaidi
    7. Yongsheng Ding

    • Curated by eLife

      eLife Assessment

      This study presents valuable findings on the role of KLF6 in in vitro endothelial cells exposed to altered (high or low) shear stress with a customized microfluidic device to investigate mechanisms of atherosclerosis. The finding that altered shear stress results in endothelial cell ferroptosis through reduced expression of KLF6 is compelling and adds a new layer of complexity to the pathogenesis of atherosclerotic plaques. However, more detailed characterization of ferroptosis is needed.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  7. Redox Dyshomeostasis Links Renal and Neuronal Dysfunction in Drosophila Models of Gaucher and Parkinson’s Disease

    1. Alexander J Hull
    2. Magda L Atilano
    3. Kerri J Kinghorn

    • Curated by eLife

      eLife Assessment

      This is a valuable manuscript that reframes Gaucher's disease pathology through the analysis of renal health, using a Drosophila model mutant for glucocerebrosidase (GBA1). The authors provide physiological and cellular data showing that renal dysfunction may be a critical disease-modifying feature. This work broadens the field's focus beyond the nervous system to include systemic ionic regulation as a potential contributor to disease initiation and progression. The genetic and experimental approaches are solid and offer a rationale for investigating analogous dysfunction in human tissues; however, several claims extend beyond the presented evidence and would benefit from additional experimental support to fully support the conclusions.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. Cryo-EM Reveals Regulatory Mechanisms Governing Substrate Selection and Activation of Human LONP1

    1. Jeffrey T Mindrebo
    2. Lauren Alexandrescu
    3. Jennifer R Baker
    4. Garret Wang
    5. Gabriel C Lander

    • Curated by eLife

      eLife Assessment

      This valuable study presents EM structures of new conformational states of the LONP1 AAA+ protease in conjunction with the mitochondrial protein substrates (StAR, TFAM), along with biochemical functional assays. The EM structures revealed new conformational states in a closed configuration. The structures and associated functional results are solid. However, a notable weakness is the absence of substrates found threaded through the ATPase pores.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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