eLife

Latest preprint reviews

1. Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8

   This article has 8 authors:

   1. Hsiang-Chun Chang
   2. Jason Solomon Shapiro
   3. Xinghang Jiang
   4. Grant Senyei
   5. Teruki Sato
   6. Justin Geier
   7. Konrad T Sawicki
   8. Hossein Ardehali

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an interesting manuscript and experiments generally make their point on Alr effects. However, additional data would strengthen the paper with respect to the relative roles of cytoplasmic vs mitochondrial isoforms as would mitochondrial function studies.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

2. A mobile genetic element increases bacterial host fitness by manipulating development

   This article has 4 authors:

   1. Joshua M Jones
   2. Ilana Grinberg
   3. Avigdor Eldar
   4. Alan D Grossman

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     All the reviewers were in agreement that this is an exceptionally rigorous paper that sets an important precedent for how mobile genetic elements can influence host biology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

3. KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

   This article has 9 authors:

   1. Anthony A Ruberto
   2. Aline Gréchez-Cassiau
   3. Sophie Guérin
   4. Luc Martin
   5. Johana S Revel
   6. Mohamed Mehiri
   7. Malayannan Subramaniam
   8. Franck Delaunay
   9. Michèle Teboul

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest in the fields of circadian biology and metabolic physiology. It provides a molecular mechanism for protection against development of fatty liver in response to high sugar consumption. Quality data support the key claims of the paper in each of the main research areas (circadian biology and metabolism) but additional efforts are needed to integrate the two parts. The current study does not thoroughly connect the in vitro and in vivo findings and misses the opportunity to fully characterize the role of KLF10 in circadian regulation in response to excessive sugar consumption.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

4. Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

   This article has 3 authors:

   1. Nadiatou T Miningou Zobon
   2. Joanna Jędrzejewska-Szmek
   3. Kim T Blackwell

   Reviewed by eLife

5. Endothelial cell senescence exacerbates pulmonary hypertension through Notch-mediated juxtacrine signaling

   This article has 8 authors:

   1. Risa Ramadhiani
   2. Koji Ikeda
   3. Kazuya Miyagawa
   4. Gusty Rizky Teguh Ryanto
   5. Naoki Tamada
   6. Yoko Suzuki
   7. Ken-ichi Hirata
   8. Noriaki Emoto

   Reviewed by eLife

6. A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

   This article has 15 authors:

   1. Pille Hallast
   2. Laura Kibena
   3. Margus Punab
   4. Elena Arciero
   5. Siiri Rootsi
   6. Marina Grigorova
   7. Rodrigo Flores
   8. Mark A Jobling
   9. Olev Poolamets
   10. Kristjan Pomm
   11. Paul Korrovits
   12. Kristiina Rull
   13. Yali Xue
   14. Chris Tyler-Smith
   15. Maris Laan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study presents extensive genetic analysis of a relatively large cohort of men with idiopathic infertility, with considerable accompanying andrological phenotypic data. Through careful step-by-step investigations, an inversion variant is identified as a risk factor for subsequent deletion variants that can lead to substantially increased risk of impaired spermatogenesis, on an age-structured basis, relative to non-carriers. This work will be of particular interest to the reproductive genetics field, but also has wide ranging implications for colleagues interested in common disease genetics, meiosis, structural variation, dosage sensitivity, and sex chromosome evolution. As part of the most comprehensive investigation of AZFc micro-deletions and structural variation to date, the authors have identified a novel structural variant of the Y-chromosome that predisposes to spermatogenic failure and provided clear guidelines for genetic counseling.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

   This article has 11 authors:

   1. Ka-Cheuk Liu
   2. Alethia Villasenor
   3. Maria Bertuzzi
   4. Nicole Schmitner
   5. Niki Radros
   6. Linn Rautio
   7. Kenny Mattonet
   8. Ryota L Matsuoka
   9. Sven Reischauer
   10. Didier YR Stainier
   11. Olov Andersson

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an elegant study demonstrating the emergence of mesoderm-derived beta-like cells following beta-cell ablation in an endothelial cell deficient context. These findings will be of interest to scientists in the areas of regeneration and reprogramming, as they reveal a previously unknown degree of germ layer plasticity in the embryo. In the long term the study has potential impact in the diabetes field, as it reveals a novel path for redirecting somatic cells into insulin-producing cells in an in vivo context.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

8. Decoding subjective emotional arousal from EEG during an immersive virtual reality experience

   This article has 6 authors:

   1. Simon M Hofmann
   2. Felix Klotzsche
   3. Alberto Mariola
   4. Vadim Nikulin
   5. Arno Villringer
   6. Michael Gaebler

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: Hofmann et al. investigate the link between two phenomena, emotional arousal and cortical alpha activity. Although alpha activity is tightly linked to the first reports of electric activity in the brain nearly 100 years ago, a comprehensive characterization of this phenomenon is elusive. One of the reasons is that EEG, the major method to investigate electric activity in the human brain, is susceptible to motion artifacts and, thus, mostly used in laboratory settings. Here, the authors combine EEG with virtual reality (VR) to give experimental participants a roller-coaster ride with high immersion. The ride, literally, leads to large ups and downs in emotional arousal, which is quantified by the subjects during a later rerun. Three different decoding methods were evaluated (Source Power Comodulation, Common Spatial Patterns, and Long Short-Term Memory Recurrent Neural Networks), each of which demonstrated above-chance levels of performance, substantiating a link between lower levels of parietal/occipital alpha and subjective arousal in a quasi-naturalistic setting.

     The reviewers both expressed some enthusiasm for the MS:

     The study is timely and makes an important contribution to our understanding of the relation of emotions and sensory processing

     Of potentially great interest to a broad audience

     The embedding in historic literature is excellent. I like it a lot.

     This work is notable because the roller-coaster simulation is a well-controlled, yet dynamic manipulation of arousal, and in its comparison of multiple decoding approaches (that can model the dynamics of affective responses). Indeed, this is an interesting proof of concept that shows it is possible to decode affective experience from brain activity measured during immersive virtual reality.

     Reviewer #1 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

9. Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

   This article has 9 authors:

   1. Rachel A Johnston
   2. Philippe Vullioud
   3. Jack Thorley
   4. Henry Kirveslahti
   5. Leyao Shen
   6. Sayan Mukherjee
   7. Courtney M Karner
   8. Tim Clutton-Brock
   9. Jenny Tung

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript takes a deep dive into the skeletal effects of burrowing and eusocial Damaraland mole rats. By exploring the genetic and skeletal consequences of breeding restricted to a single queen with multiple and closely-timed pregnancies and lactation, this study offers a compelling story that will bolster textbooks on skeletal biology, mammalian evolution, and ethology. The results show the molecular mechanisms driving adaptive plasticity within the unusually expanded lumbar spine and thin limb bones of queens are an adaptive consequence of breeding status.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast

    This article has 12 authors:

    1. Rachael Emily Turner
    2. Paul F Harrison
    3. Angavai Swaminathan
    4. Calvin A Kraupner-Taylor
    5. Belinda J Goldie
    6. Michael See
    7. Amanda L Peterson
    8. Ralf B Schittenhelm
    9. David R Powell
    10. Darren J Creek
    11. Bernhard Dichtl
    12. Traude H Beilharz

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This study aims to provide a comprehensive analysis of factors governing polyadenylation site selection in yeast. Overall, the authors reveal that multiple but distinct inputs including polyadenylation machinery integrity, transcription elongation rate, nucleotide availability and chromatin landscape all contribute to controlling cleavage and polyadenylation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife