eLife

Latest preprint reviews

1. The propofol binding sites of prokaryotic voltage-gated sodium channels

   This article has 11 authors:

   1. Elaine Yang
   2. Weiming Bu
   3. Antonio Suma
   4. Vincenzo Carnevale
   5. Kimberly C. Grasty
   6. Patrick Loll
   7. Kellie Woll
   8. Natarajan Bhanu
   9. Benjamin A. Garcia
   10. Roderic G. Eckenhoff
   11. Manuel Covarrubias

   Reviewed by eLife

2. An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

   This article has 5 authors:

   1. Rossana Droghetti
   2. Nicolas Agier
   3. Gilles Fischer
   4. Marco Gherardi
   5. Marco Cosentino Lagomarsino

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers appreciate that the manuscript presents a simple but compelling model that explains the dynamics of replication origin birth and death, which enhances our understanding of the selection pressures that have shaped the distribution of replication origins. However, both reviewers had a series of concerns.

   Reviewed by eLife

3. The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

   This article has 12 authors:

   1. Patrick Morley Willoughby
   2. Molly Allen
   3. Jessica Yu
   4. Roman Korytnikov
   5. Tianhui Chen
   6. Yupeng Liu
   7. Isis So
   8. Haoyu Wan
   9. Neil Macpherson
   10. Jennifer A Mitchell
   11. Rodrigo Fernandez-Gonzalez
   12. Ashley EE Bruce

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Willoughby et al. examine the role of Rab25 in early embryogenesis in zebrafish. They implicate Rab25 activity in abscission and show various defects including delayed epiboly and altered cell behaviors associated with defective acting dynamics. Overall, this is an interesting and well-written paper. However, there are a number of important controls that are missing and some connections such as the implication of membrane recycling that require stronger experimental validation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

4. Perception of microstimulation frequency in human somatosensory cortex

   This article has 6 authors:

   1. Christopher L Hughes
   2. Sharlene N Flesher
   3. Jeffrey M Weiss
   4. Michael Boninger
   5. Jennifer L Collinger
   6. Robert A Gaunt

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper characterizes percepts evoked by micro-stimulating the somatosensory cortex of a human participant. The study provides some new insight into the organization of the human somatosensory cortex and represents an important step in providing more effective somatosensory feedback for brain-machine interface users.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

5. Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans

   This article has 29 authors:

   1. Trygve E Bakken
   2. Cindy TJ van Velthoven
   3. Vilas Menon
   4. Rebecca D Hodge
   5. Zizhen Yao
   6. Thuc Nghi Nguyen
   7. Lucas T Graybuck
   8. Gregory D Horwitz
   9. Darren Bertagnolli
   10. Jeff Goldy
   11. Anna Marie Yanny
   12. Emma Garren
   13. Sheana Parry
   14. Tamara Casper
   15. Soraya I Shehata
   16. Eliza R Barkan
   17. Aaron Szafer
   18. Boaz P Levi
   19. Nick Dee
   20. Kimberly A Smith
   21. Susan M Sunkin
   22. Amy Bernard
   23. John Phillips
   24. Michael J Hawrylycz
   25. Christof Koch
   26. Gabe J Murphy
   27. Ed Lein
   28. Hongkui Zeng
   29. Bosiljka Tasic

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This manuscript provides a comparative analysis of the cell variety present in the dorsal lateral geniculate nucleus (dLGN) of mice, non-human primates, and humans using single-cell/single-nucleus RNA-sequencing (Smart-seq). The study identifies excitatory and inhibitory dLGN cell types in the three species and shows that the different subclasses of inhibitory neurons are relatively similar across species. In contrast, excitatory neurons appear to bear cross-species differences particularly between mouse and primates. The study provides an extensive description of the dLGN neurons, an important visual relay nucleus that has been so far poorly studied. As such, these data are very welcomed and will likely attract the interest of researchers working in visual function and beyond. The strong and creative bioinformatics analysis has uncovered interesting and subtle cross species links between different types of neurons.

     Reviewer #1, Reviewer #2 and Reviewer #3 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

6. Multimodal FDG-PET and EEG assessment improves diagnosis and prognostication of disorders of consciousness

   This article has 10 authors:

   1. Bertrand Hermann
   2. Johan Stender
   3. Marie-Odile Habert
   4. Aurélie Kas
   5. Mélanie Denis-Valente
   6. Federico Raimondo
   7. Pauline Pérez
   8. Benjamin Rohaut
   9. Jacobo Diego Sitt
   10. Lionel Naccache

   Reviewed by eLife

7. Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

   This article has 13 authors:

   1. Savannah F Bifulco
   2. Griffin D Scott
   3. Sakher Sarairah
   4. Zeinab Birjandian
   5. Caroline H Roney
   6. Steven A Niederer
   7. Christian Mahnkopf
   8. Peter Kuhnlein
   9. Marcel Mitlacher
   10. David Tirschwell
   11. WT Longstreth
   12. Nazem Akoum
   13. Patrick M Boyle

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript, the authors try to answer an important clinical question about the previously observed connection between embolic stroke of undetermined source (ESUS) and atrial fibrillation (AF). Using cutting-edge personalized computational modeling of left atrium from both ESUS and AFib patients, the researchers try to understand why the fibrotic substrate found in both ESUS and AFib patients causes arrhythmia in the latter group but not the former. Their study concludes that the intrinsic capacity to sustain arrhythmias of fibrosis found in ESUS and AFib atrium are identical. The key claims of the manuscript are well supported by the data, and the modeling methodology is largely appropriate.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

8. Using viral genomics to estimate undetected infections and extent of superspreading events for COVID-19

   This article has 2 authors:

   1. Lucy M. Li
   2. Patrick Ayscue

   Reviewed by eLife, ScreenIT

9. Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

   This article has 11 authors:

   1. Ghulam R Awab
   2. Fahima Aaram
   3. Natsuda Jamornthanyawat
   4. Kanokon Suwannasin
   5. Watcharee Pagornrat
   6. James A Watson
   7. Charles J Woodrow
   8. Arjen M Dondorp
   9. Nicholas PJ Day
   10. Mallika Imwong
   11. Nicholas J White

   Reviewed by eLife

10. Perinatal granulopoiesis and risk of pediatric asthma

    This article has 10 authors:

    1. Benjamin A Turturice
    2. Juliana Theorell
    3. Mary Dawn Koenig
    4. Lisa Tussing-Humphreys
    5. Diane R Gold
    6. Augusto A Litonjua
    7. Emily Oken
    8. Sheryl L Rifas-Shiman
    9. David L Perkins
    10. Patricia W Finn

    This article has been curated by 1 group:

    • Curated by eLife

      Summary: This is a nice study that is clearly written and makes use of several datasets. It attempts to explain perinatal risk factors and the associated risk of developing pediatric asthma in the mid-childhood and early teenage years. Identified among maternal characteristics that were associated with risks of subsequent asthma development included atopy, BMI, race/ethnicity and demographics, birth characteristics, and mode of delivery. The paper then goes on to demonstrate the differences in immune response during the different time frames of pregnancy. Most notably, a gene signature associated with increased myelopoiesis in utero is associated with increased risk of pediatric asthma. Furthermore they show that cord blood serum PGLYRP -1 is associated with reduced risk of pediatric asthma and increased FEV1/FVC. Interestingly sIL6ra which is derived from neutrophils but not associated with neutrophil granules did not show any association with pulmonary outcomes. This suggests that it is the neutrophil granules rather than the neutrophils per se that are the problem association.

    Reviewed by eLife