eLife

Latest preprint reviews

1. Membrane binding controls ordered self-assembly of animal septins

   This article has 8 authors:

   1. Agata Szuba
   2. Fouzia Bano
   3. Gerard Castro-Linares
   4. Francois Iv
   5. Manos Mavrakis
   6. Ralf P Richter
   7. Aurélie Bertin
   8. Gijsje H Koenderink

   Reviewed by eLife

2. Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a

   This article has 6 authors:

   1. Yuta Nakazawa
   2. Nanako Nishiyama
   3. Hitoshi Koizumi
   4. Kazumasa Kanemaru
   5. Chigusa Nakahashi-Oda
   6. Akira Shibuya

   Reviewed by eLife

3. Replay as structural inference in the hippocampal-entorhinal system

   This article has 2 authors:

   1. Talfan Evans
   2. Neil Burgess

   Reviewed by eLife

4. Freshwater monitoring by nanopore sequencing

   This article has 12 authors:

   1. Lara Urban
   2. Andre Holzer
   3. J Jotautas Baronas
   4. Michael B Hall
   5. Philipp Braeuninger-Weimer
   6. Michael J Scherm
   7. Daniel J Kunz
   8. Surangi N Perera
   9. Daniel E Martin-Herranz
   10. Edward T Tipper
   11. Susannah J Salter
   12. Maximilian R Stammnitz

   Reviewed by eLife

5. Learning excitatory-inhibitory neuronal assemblies in recurrent networks

   This article has 3 authors:

   1. Owen Mackwood
   2. Laura B Naumann
   3. Henning Sprekeler

   Reviewed by eLife

6. A pentameric protein ring with novel architecture is required for herpesviral packaging

   This article has 6 authors:

   1. Allison L Didychuk
   2. Stephanie N Gates
   3. Matthew R Gardner
   4. Lisa M Strong
   5. Andreas Martin
   6. Britt A Glaunsinger

   Reviewed by eLife

7. Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

   This article has 10 authors:

   1. Johanna S. Jackson
   2. James D. Johnson
   3. Soraya Meftah
   4. Tracey K Murray
   5. Zeshan Ahmed
   6. Matteo Fasiolo
   7. Michael L. Hutton
   8. John T.R. Isaac
   9. Michael J. O’Neill
   10. Michael C. Ashby

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This paper describes studies of a mouse model of tauopathy with relevance to Alzheimer's Disease. A powerful approach of longitudinal imaging of single synaptic structures over time allows insights into the time course of progressive neurogenerative responses. The strengths of the report are the relevance of the question to human disease, the powerful imaging approach, and the indication that there may be a programmed sequence of structural changes that mediate tauopathy. On the other hand, there were multiple issues with the transgenic mouse model used, which would seriously limit interpretation of results without suitable controls. Further, the data set appeared to be quite noisy, and variable between animals, which may result in part from the nonspecific methods of expressing fluorescent markers, thus leading to uncertainty regarding the specific identity of pre- and post-synaptic elements.

   Reviewed by eLife

8. A computationally designed fluorescent biosensor for D-serine

   This article has 13 authors:

   1. Vanessa Vongsouthi
   2. Jason H. Whitfield
   3. Petr Unichenko
   4. Joshua A. Mitchell
   5. Björn Breithausen
   6. Olga Khersonsky
   7. Leon Kremers
   8. Harald Janovjak
   9. Hiromu Monai
   10. Hajime Hirase
   11. Sarel J. Fleishman
   12. Christian Henneberger
   13. Colin J. Jackson

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers recognize the merits of your work and your efforts to engineer a D-serine selective biosensor. However, they also raise major concerns regarding the experimental design (selection of mutations), methodology and achieved applicability. The reviewers find that the improvement in the selectivity of the engineered construct for the targeted ligand over alternative ligands is modest. They further indicate ambiguities regarding the origin of the ligand-induced fluorescence signal changes of the sensor. Other problematic aspects are the estimation of thermal stabilities and the lack of physiological signals in fluorescence imaging results that could demonstrate applicability to a biological problem.

   Reviewed by eLife

9. Linking minimal and detailed models of CA1 microcircuits reveals how theta rhythms emerge and their frequencies controlled

   This article has 3 authors:

   1. Alexandra Pierri Chatzikalymniou
   2. Melisa Gumus
   3. Frances K. Skinner

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This study tackles a difficult problem of understanding the basis for hippocampal theta rhythms through reduction of a highly detailed model, seeking to validate a reduced model that would be more amenable to analysis. The reviewers appreciated the attention to this challenging problem and the substantial work that went into it, but had several fundamental concerns about the methodology, interpretation, and reporting.

   Reviewed by eLife

10. Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

    This article has 2 authors:

    1. Melissa J Polonenko
    2. Ross K Maddox

    This article has been curated by 1 group:

    • Curated by eLife

      Summary: This manuscript describes a type of alteration to speech to make it more peaky, with the goal of inducing stronger responses in the auditory brainstem. Recent work has employed naturalistic speech to investigate subcortical mechanisms of speech processing. However, previous methods were ill equipped to tease apart the neural responses in different parts of the brainstem. The authors show that their speech manipulation improves this: the peaky speech that they develop allows to segregate different waves of the brainstem response. This development may allow further and more refined investigations of the contribution of different parts of the brainstem to speech processing, as well as to hearing deficits.

    Reviewed by eLife