eLife

Latest preprint reviews

1. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution

   This article has 4 authors:

   1. M. J. Higgs
   2. M. J. Hill
   3. R. M. John
   4. A. R. Isles

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers appreciated the effort to merge most of the available datasets to make a precise survey of the sites of imprinted gene expression and the great resource it could bring to the community. However, the reviewers also felt that the study suffered from methodological bias, was preliminary (no allelic information in particular), and that the conclusions did not go beyond previous reports. The general lack of citation of the name of imprinted genes made it difficult to judge whether conclusions were consistent among the different datasets. Highlighting specific imprinted genes would bring a clearer focus and narrative.

   Reviewed by eLife

2. Brain network reconfiguration for narrative and argumentative thought

   This article has 5 authors:

   1. Yangwen Xu
   2. Lorenzo Vignali
   3. Olivier Collignon
   4. Davide Crepaldi
   5. Roberto Bottini

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers thought this was a nicely written paper, and were interested in the idea of extending intersubject correlation (ISC) and intersubject functional connectivity (ISFC) work on narratives to arguments. One major concern was that effects reported here may be driven in part by the scrambled conditions. Specifically, the scrambled argument seems to have resulted in stronger and more widespread ISC than the intact argument: this would call into question assumptions about the scrambled version being a control condition. Another, related concern raised is that perhaps argumentative texts are very different from narrative texts: perhaps argumentative texts are less structured, or less interesting (?) and this is why the intact and scrambled versions are so similar. Together with other issues, relating to the interpretation of the findings, it was felt that while of interest, the study's major conclusions could not be justified without additional experiments.

   Reviewed by eLife

3. Evoked pain intensity representation is distributed across brain systems: A multistudy mega-analysis

   This article has 11 authors:

   1. Bogdan Petre
   2. Philip Kragel
   3. Lauren Y. Atlas
   4. Stephan Geuter
   5. Marieke Jepma
   6. Leonie Koban
   7. Anjali Krishnan
   8. Marina Lopez-Sola
   9. Mathieu Roy
   10. Choong-Wan Woo
   11. Tor D. Wager

   Reviewed by eLife

4. Can computers understand words like humans do? Comparable semantic representation in neural and computer systems

   This article has 8 authors:

   1. Linmin Zhang
   2. Lingting Wang
   3. Jinbiao Yang
   4. Peng Qian
   5. Xuefei Wang
   6. Xipeng Qiu
   7. Zheng Zhang
   8. Xing Tian

   Reviewed by eLife

5. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

   This article has 9 authors:

   1. Xiaochen Fan
   2. V Pragathi Masamsetti
   3. Jane QJ Sun
   4. Kasper Engholm-Keller
   5. Pierre Osteil
   6. Joshua Studdert
   7. Mark E Graham
   8. Nicolas Fossat
   9. Patrick PL Tam

   Reviewed by eLife

6. Neural signatures of vigilance decrements predict behavioural errors before they occur

   This article has 3 authors:

   1. Hamid Karimi-Rouzbahani
   2. Alexandra Woolgar
   3. Anina N Rich

   Reviewed by eLife

7. The population genetics of collateral resistance and sensitivity

   This article has 2 authors:

   1. Sarah M Ardell
   2. Sergey Kryazhimskiy

   Reviewed by eLife

8. Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses

   This article has 4 authors:

   1. Juan Jose Rodriguez Gotor
   2. Kashif Mahfooz
   3. Isabel Perez-Otano
   4. John F Wesseling

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study addresses the long-standing question as to how different functional pools of synaptic vesicles are organized in presynaptic terminals to mediate different modes of neurotransmitter release. Based on imaging of active synapses with recycling synaptic vesicles labeled by FM-styryl dyes, the authors provide data that are compatible with the hypothesis that two separate reserve pools of vesicles – slowly vs. rapidly mobilizing – feed two distinct releasable pools – reluctantly vs. rapidly releasing. Overall, this study represents a valuable contribution to the field of synapse biology, specifically to presynaptic dynamics and plasticity. The authors' methodological approach of using bulk FM-styryl dye destaining as a readout of precise vesicle arrangements and pools in a population of functionally very diverse synapses has limitations. Consequently, the evidence that directly supports the authors' two-pool-interpretation of their data is incomplete, and alternative interpretations of the data remain possible.

   Reviewed by eLife

9. Timing matters: The temporal representation of experience in subjective mood reports

   This article has 9 authors:

   1. Hanna Keren
   2. Charles Zheng
   3. David C. Jangraw
   4. Katharine Chang
   5. Aria Vitale
   6. Dylan Nielson
   7. Robb B. Rutledge
   8. Francisco Pereira
   9. Argyris Stringaris

   Reviewed by eLife

10. Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

    This article has 8 authors:

    1. Baruch Haimson
    2. Yoav Hadas
    3. Nimrod Bernat
    4. Artur Kania
    5. Monica A Daley
    6. Yuval Cinnamon
    7. Aharon Lev-Tov
    8. Avihu Klar

    Reviewed by eLife