eLife

Latest preprint reviews

1. Causal neural mechanisms of context-based object recognition

   This article has 2 authors:

   1. Miles Wischnewski
   2. Marius V Peelen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study will be of interest to scientists involved in high-level vision. The data provide a compelling demonstration of the causal role of three key visual areas in context-based object recognition. The key claims of the manuscript are supported by the data, and are strengthened by the pre-registration of each of the three experiments.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

2. Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

   This article has 8 authors:

   1. Yoanna Ariosa-Morejon
   2. Alberto Santos
   3. Roman Fischer
   4. Simon Davis
   5. Philip Charles
   6. Rajesh Thakker
   7. Angus KT Wann
   8. Tonia L Vincent

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Capturing the rate and degree of protein turnover in tissues rich in collagen, proteoglycans and glycoproteins over the life span provides valuable information about how these tissues age and can increase our understanding of age-related disease. Using a Stable Isotope Labeling (SILAC) method to examine protein retention, new protein incorporation and protein turnover in three high collage content tissues, the authors show that turnover is low in older mice in these tissues, but the depth of the data generated provide a detailed examination of what low turnover means at a level we have not previously had. This paper would be of interest to a broad range of scientists studying connective tissues in the context of development and ageing.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Distinct synaptic transfer functions in same-type photoreceptors

   This article has 5 authors:

   1. Cornelius Schröder
   2. Jonathan Oesterle
   3. Philipp Berens
   4. Takeshi Yoshimatsu
   5. Tom Baden

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper compares the properties of UV cone output synapses in different regions of the zebrafish retina using a combination of electron microscopy, quantitative imaging and computational modeling. They relate these differences to ultrastructural differences in synaptic ribbons and evaluate them using a previously-developed biophysical model for the operation of the synapse. The finding of regional differences in ribbon behavior is novel and suggests an under-appreciated degree of control of release by ribbon structure and behavior. The presentation of some of the results, particularly the model, could be strengthened.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

4. Mapping brain-behavior space relationships along the psychosis spectrum

   This article has 17 authors:

   1. Jie Lisa Ji
   2. Markus Helmer
   3. Clara Fonteneau
   4. Joshua B Burt
   5. Zailyn Tamayo
   6. Jure Demšar
   7. Brendan D Adkinson
   8. Aleksandar Savić
   9. Katrin H Preller
   10. Flora Moujaes
   11. Franz X Vollenweider
   12. William J Martin
   13. Grega Repovš
   14. Youngsun T Cho
   15. Christopher Pittenger
   16. John D Murray
   17. Alan Anticevic

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors assessed multivariate relations between a dimensionality-reduced symptom space and brain imaging features, using a large database of individuals with psychosis-spectrum disorders (PSD). Demonstrating both high stability and reproducibility of their approaches, this work showed a promise that diagnosis or treatment of PSD can benefit from a proposed data-driven brain-symptom mapping framework. It is therefore of broad potential interest across cognitive and translational neuroscience.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. Stronger net selection on males across animals

   This article has 4 authors:

   1. Lennart Winkler
   2. Maria Moiron
   3. Edward H Morrow
   4. Tim Janicke

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study addresses an interesting and important question in evolutionary biology: how does the variance in fitness (components) vary between the sexes? In particular, it aims to evaluate whether there is a larger sex difference in systems with strong sexual selection. This study will be of considerable interest to researchers working on sexual coevolution and the role of sexual selection in promoting adaptation. However, there are some concerns regarding the limitations of the data and methods in support of the conclusions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

6. High-speed, three-dimensional imaging reveals chemotactic behaviour specific to human-infective Leishmania parasites

   This article has 6 authors:

   1. Rachel C Findlay
   2. Mohamed Osman
   3. Kirstin A Spence
   4. Paul M Kaye
   5. Pegine B Walrad
   6. Laurence G Wilson

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study utilizes holographic microscopy to study the swimming behaviour of flagellated forms of Leishmania mexicana in the presence or absence of host cell stimuli. Infective metacyclic promastigotes were found to swim faster than actively dividing procyclic promastigotes and to display different average trajectories. The swimming trajectories of these parasite stages were also altered in the presence of macrophages, promoting chemotaxis towards target host cells. The findings provide new insights into promastigote flagellar function and role of swimming behaviour in promoting pathogenesis.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

7. Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

   This article has 6 authors:

   1. Miriam S Weber
   2. Matthias Eibauer
   3. Suganya Sivagurunathan
   4. Thomas M Magin
   5. Robert D Goldman
   6. Ohad Medalia

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work combines 2D and 3D cryo-electron microscopy to show that cellular keratin intermediate filaments have heterogenous diameter, protofilament number and protofilament arrangement. This demonstrates the challenge for future high resolution structure determination of these essential filaments as well as providing the basis for understanding how this heterogeneity facilitates their function.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

8. Developmental changes in story-evoked responses in the neocortex and hippocampus

   This article has 3 authors:

   1. Samantha S Cohen
   2. Nim Tottenham
   3. Christopher Baldassano

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Cohen and Baldassano present analyses of a large publicly available set of neuroimaging data from children and adolescents watching an animated movie, and is likely be of interest to neuroscientists interested in methods for analyzing naturalistic neuroimaging data, or those interested in the development of narrative processing in the brain. The results are not embedded in a strong theoretical framework and it is not yet clear which hypotheses are supported and which are refuted. However, the methodological approach developed here is a valuable addition to the repertoire of developmental neuroscience.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

9. Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

   This article has 24 authors:

   1. Elizabeth Jaworski
   2. Rose M Langsjoen
   3. Brooke Mitchell
   4. Barbara Judy
   5. Patrick Newman
   6. Jessica A Plante
   7. Kenneth S Plante
   8. Aaron L Miller
   9. Yiyang Zhou
   10. Daniele Swetnam
   11. Stephanea Sotcheff
   12. Victoria Morris
   13. Nehad Saada
   14. Rafael RG Machado
   15. Allan McConnell
   16. Steven G Widen
   17. Jill Thompson
   18. Jianli Dong
   19. Ping Ren
   20. Rick B Pyles
   21. Thomas G Ksiazek
   22. Vineet D Menachery
   23. Scott C Weaver
   24. Andrew L Routh

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The ability to fully resolve the whole genome of viral pathogens is often hampered by a multitude of different obstacles, one of which is optimally amplifying different regions of the genome. Part of this challenge lies in designing the best primers pairs that can consistently amplify PCR products despite the presence of changes (mutations) in the genome. The work described by Jaworski and colleagues can potentially provide an alternative approach that does not depend on primer pairs to fully sequence one such viral pathogen, SARS-CoV-2, and can also be applied towards other viral families.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife, ScreenIT

10. Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

    This article has 16 authors:

    1. Daisy X Ji
    2. Kristen C Witt
    3. Dmitri I Kotov
    4. Shally R Margolis
    5. Alexander Louie
    6. Victoria Chevée
    7. Katherine J Chen
    8. Moritz M Gaidt
    9. Harmandeep S Dhaliwal
    10. Angus Y Lee
    11. Stephen L Nishimura
    12. Dario S Zamboni
    13. Igor Kramnik
    14. Daniel A Portnoy
    15. K Heran Darwin
    16. Russell E Vance

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      Understanding genes that control susceptibility to infection is critically important. In this manuscript Ji et al. identify the gene SP140 as the driving mutation resulting in susceptibility to a range of bacterial pathogens located within the severe susceptibility to tuberculosis (SST1) in mice. While our understanding of how SP140 functions remains unknown, the identification of a single gene within this locus that regulates Type I IFN is impactful and will be of broad interest for immunologists and microbiologists alike.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife