eLife

Latest preprint reviews

1. The role of higher-order thalamus during learning and correct performance in goal-directed behavior

   This article has 6 authors:

   1. Danilo La Terra
   2. Ann-Sofie Bjerre
   3. Marius Rosier
   4. Rei Masuda
   5. Tomás J Ryan
   6. Lucy M Palmer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study, which will be of interest to neuroscientists in the fields of learning and memory, somatosensation, and motor behavior, uses systems neuroscience tools to expand our view how the postero-medial (POm) nucleus of the thalamus contributes to goal-directed behavior. The reviewers suggested additional ontogenetic experiments to clarify the nature and specificity of those roles. They also indicated that certain alternative explanations to the experimental observations could be addressed for a more balanced presentation and interpretation of the results.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

2. Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues

   This article has 4 authors:

   1. Kevin Vinberg
   2. Jörgen Rosén
   3. Granit Kastrati
   4. Fredrik Ahs

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Vinbert et al. provide a conceptual replication on individual differences in conditioned skin conductance response during fear acquisition training and BOLD fMRI in a large sample (N=285) of healthy individuals (mono- and dizygotic twins). The authors report results that are in line with previous work and new results from a whole-brain analysis and suggest unique and shared contributions of individual brain regions. This is a timely and well-conducted replication study, the sample size is large for this area, and there are robustness (multiverse) analyses in place to ensure that findings are not driven by particular analysis choices.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

3. Discovery and characterization of Hv1-type proton channels in reef-building corals

   This article has 9 authors:

   1. Gisela Rangel-Yescas
   2. Cecilia Cervantes
   3. Miguel A Cervantes-Rocha
   4. Esteban Suárez-Delgado
   5. Anastazia T Banaszak
   6. Ernesto Maldonado
   7. Ian Scott Ramsey
   8. Tamara Rosenbaum
   9. Leon D Islas

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest both to marine biologists and to biophysicists studying voltage-gated proton channels. It describes cloning and full biophysical characterization of the first ion channel ever identified in reef-building coral species, and develops a mechanistic model for understanding regulation of voltage-gated proton channels.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

4. Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells

   This article has 10 authors:

   1. Maria Eugenia Dieterle
   2. Carles Solà-Riera
   3. Chunyan Ye
   4. Samuel M Goodfellow
   5. Eva Mittler
   6. Ezgi Kasikci
   7. Steven B Bradfute
   8. Jonas Klingström
   9. Rohit K Jangra
   10. Kartik Chandran

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a well-performed study that defines the role of purported host cell receptors in the entry of hantaviruses into human endothelial cells. This is an important study as it applies CRISPR-mediated deletion studies for candidate receptors in the same endothelial cell line (TIME).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

5. Direct extraction of signal and noise correlations from two-photon calcium imaging of ensemble neuronal activity

   This article has 6 authors:

   1. Anuththara Rupasinghe
   2. Nikolas Francis
   3. Ji Liu
   4. Zac Bowen
   5. Patrick O Kanold
   6. Behtash Babadi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This article is of general interest to scientists who perform two-photon calcium imaging in vivo and explore the link between function and structure in real neural networks. The development of efficient approaches to estimate true correlations between large sets of noisy individual neurons based on realistic and thus limited observation time is a key to better understand functional local circuits. The effectiveness of the proposed method is illustrated by simulations and applied on real data, but several steps in its procedure remain to be clarified in the current form of the manuscript to be usable by a wide range of users.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

   This article has 6 authors:

   1. Danielle Holz
   2. Aaron R Hall
   3. Eiji Usukura
   4. Sawako Yamashiro
   5. Naoki Watanabe
   6. Dimitrios Vavylonis

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this work, Holz and colleagues develop a computational stochastic model of lamellipodial actin network growth and turnover to address an unresolved important question: how do these networks remain wide enough, maintain angular order, and actually increase the filament length behind the leading edge? They compare the filament organization and rate of incorporation/detachment of actin subunits with experimental data published in the literature. A main result from this study is that frequent filament fragmentation and annealing are key events in the reorganization of branched actin networks. The paper is well written, contains very thorough and fair literature review, is accurate, well documented. The result is novel and significant.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking

   This article has 6 authors:

   1. Kotryna Vaidžiulytė
   2. Anne-Sophie Macé
   3. Aude Battistella
   4. William Beng
   5. Kristine Schauer
   6. Mathieu Coppey

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Cell movement is essential for development and tissue homeostasis. While the cellular machineries involved in movement have been well studied, how cells maintain a persistent direction of motion is less well understood. Here, Coppey's team shows that movement persistence emerges from the coupling of two cellular systems: protrusions at the leading edge and polarity of secretion. This coupling is controlled by the small GTPase Cdc42. The authors propose a physical model that recapitulates the coupling, defines two key parameters and explains persistent cell migration.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

8. Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

   This article has 12 authors:

   1. Thomas M Rawlings
   2. Komal Makwana
   3. Deborah M Taylor
   4. Matteo A Molè
   5. Katherine J Fishwick
   6. Maria Tryfonos
   7. Joshua Odendaal
   8. Amelia Hawkes
   9. Magdalena Zernicka-Goetz
   10. Geraldine M Hartshorne
   11. Jan J Brosens
   12. Emma S Lucas

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of broad interest to scientists in the field of reproduction and has clinical relevance. It builds on innovative studies interrogating the impact of cell senescence on stromal cell differentiation and embryo implantation. It presents the development of a novel co-culture system taking advantage of organoid technology to study cell-specific interactions and outcomes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewers #1, #2, and #3 agreed to share their names with the authors.)

   Reviewed by eLife

9. A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

   This article has 11 authors:

   1. Ana C Sias
   2. Ashleigh K Morse
   3. Sherry Wang
   4. Venuz Y Greenfield
   5. Caitlin M Goodpaster
   6. Tyler M Wrenn
   7. Andrew M Wikenheiser
   8. Sandra M Holley
   9. Carlos Cepeda
   10. Michael S Levine
   11. Kate M Wassum

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study examined the neural mechanism underlying stimulus-outcome associations. Using a series of sophisticated experiments with otpogenetics and pharmacogenetics, the authors show that interactions between the basolateral amygdala (BLA) and the lateral part of the orbitofrontal cortex (lOFC) play critical role in learning to predict the identity of outcome predicted by a cue, but not in learning to predict reward generally. These results extend our understanding of how BLA and lOFC regulate the formation of associative learning and subsequent decision-making.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

    This article has 7 authors:

    1. Blaise Robert
    2. Eyal Y Kimchi
    3. Yurika Watanabe
    4. Tatenda Chakoma
    5. Miao Jing
    6. Yulong Li
    7. Daniel B Polley

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper will be of interest to neuroscientists studying the effects of cholinergic modulation throughout the brain. It provides strong support for the view that activity in the basal forebrain cholinergic system is not monolithic, but varies across the rostrocaudal axis, consistent with previous reports of differential connectivity of these areas. Strong evidence for regional differences in cholinergic responses collected simultaneously under multiple behavioral conditions provides valuable context for interpreting variability in existing and future studies.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife