eLife

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1. We couldn't get details of this article at this time:
   10.1101/2021.04.07.438431

2. Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria

   This article has 6 authors:

   1. Athina Georgiadou
   2. Claire Dunican
   3. Pablo Soro-Barrio
   4. Hyun Jae Lee
   5. Myrsini Kaforou
   6. Aubrey J Cunnington

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this work, the authors use independent public datasets to perform an unbiased investigation of the similarities and differences of mouse models to human malarial disease using comparative transcriptomics. Whilst the data cannot convincingly identify which mouse models are best suited for studying specific human malaria phenotypes, the comparative analyses do indicate that these models reflect the broad diversity of human disease.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua

   This article has 6 authors:

   1. Soeun Kim
   2. Guk-Yeol Park
   3. Jong Seok Park
   4. Jiho Park
   5. Hyebeen Hong
   6. Yoontae Lee

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper focuses on the transcriptional regulation of the T cell receptor (TCR) signaling cascade and would be of interest to those studying T cell development and differentiation. The authors employ a conditional deletion of the Capicua (Cic) gene, a transcriptional repressor previously shown to be involved in regulating autoimmunity and follicular helper T (Tfh) cell differentiation, and now show that loss of CIC in hematopoietic cells leads to defects in TCR-beta selection as well as in positive and negative selection of developing thymocytes. The overall conclusions are well supported by the findings.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

4. Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium

   This article has 11 authors:

   1. Tobias Gerber
   2. Cristina Loureiro
   3. Nico Schramma
   4. Siyu Chen
   5. Akanksha Jain
   6. Anne Weber
   7. Anne Weigert
   8. Malgorzata Santel
   9. Karen Alim
   10. Barbara Treutlein
   11. J Gray Camp

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Single celled organisms are assumed to be smaller, simpler, and less complex than multicellular organisms like animals. However, there are many examples of large single-celled protists - especially amoeba - that can be up to centimeters in size, and it remains unclear how they are able to achieve these sizes and differentiated regions like tissues in animals. Here, the authors provide evidence for variation in gene expression in the syncytial (multinucleate) large amoeba Physarum polycephalum. While primarily descriptive work, the authors are claiming a provocative mechanistic interpretation of the single cell gene expression results, but not yet supported by the current data. This study is neverhteless elegant and interesting regarding heterogeneity of gene expression patterns and thus specialization of functions within a syncytial organism.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. Echolocating toothed whales use ultra-fast echo-kinetic responses to track evasive prey

   This article has 7 authors:

   1. Heather Vance
   2. Peter T Madsen
   3. Natacha Aguilar de Soto
   4. Danuta Maria Wisniewska
   5. Michael Ladegaard
   6. Sascha Hooker
   7. Mark Johnson

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper on echolocation-mediated responses to prey movements will be of interest to a broad audience, including ethologists and neuroscientists as well as those more generally interested in the natural world. Its strengths come from the use of data from both wild and captive animals of different species of toothed whales, as well as trained harbour porpoises, enabling generalization of the findings and conclusions on sensory-motor feedback.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. Motor planning brings human primary somatosensory cortex into action-specific preparatory states

   This article has 3 authors:

   1. Giacomo Ariani
   2. J Andrew Pruszynski
   3. Jörn Diedrichsen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors studied the neural correlates of planning and execution of single finger presses in a 7T fMRI study focusing on primary somatosensory (S1) and motor (M1) cortices. BOLD patterns of activation/deactivation and finger-specific pattern discriminability indicate that M1 and S1 are involved not only during execution, but also during planning of single finger presses. These results contribute to a developing story that the role of primary somatosensory cortex goes beyond pure processing of tactile information and will be of interest for researchers in the field of motor control and of systems neuroscience.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

7. Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

   This article has 4 authors:

   1. Gabriella R Sterne
   2. Hideo Otsuna
   3. Barry J Dickson
   4. Kristin Scott

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will be of interest to scientists working on adult Drosophila behavior, especially as it relates to a region called subesophageal zone. This area is an important integration center for different nervous system functions, including taste information processing and motor control of mouth parts and body movements. Specifically, it provides genetic tools (sparse gal-4 lines) that target different cell types in the subesophageal zone for future functional analysis.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. A zebrafish embryo screen utilizing gastrulation identifies the HTR2C inhibitor pizotifen as a suppressor of EMT-mediated metastasis

   This article has 7 authors:

   1. Joji Nakayama
   2. Lora Tan
   3. Yan Li
   4. Boon Cher Goh
   5. Shu Wang
   6. Hideki Makinoshima
   7. Zhiyuan Gong

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript develops a novel approach using the zebrafish to identify suitable drugs against the spread of cancer. With some stronger support of the methodology and conclusions, it will be of interest to cancer biologists, developmental biologists, and pharmacologists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Hsp40s play complementary roles in the prevention of tau amyloid formation

   This article has 6 authors:

   1. Rose Irwin
   2. Ofrah Faust
   3. Ivana Petrovic
   4. Sharon Grayer Wolf
   5. Hagen Hofmann
   6. Rina Rosenzweig

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper addresses the intriguing hypothesis that different molecular chaperones may recognize and bind distinct tau species, and thus may use different mechanisms to prevent tau aggregation. The findings are very interesting and advance our understanding of how chaperones can counteract the deleterious effect of tau amyloidogenesis.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. Environmental fluctuations reshape an unexpected diversity-disturbance relationship in a microbial community

    This article has 5 authors:

    1. Christopher P Mancuso
    2. Hyunseok Lee
    3. Clare I Abreu
    4. Jeff Gore
    5. Ahmad S Khalil

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      How species diversity responds to external perturbations (such as resource influxes and dilutions) is an important ecological question. Using soil microbial communities in devices where perturbations can be introduced in various forms and mathematical modelling, this study nicely illustrates how diversity is influenced by perturbations.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife