eLife

Latest preprint reviews

1. BonVision – an open-source software to create and control visual environments

   This article has 12 authors:

   1. Gonçalo Lopes
   2. Karolina Farrell
   3. Edward A. B. Horrocks
   4. Chi-Yu Lee
   5. Mai M. Morimoto
   6. Tomaso Muzzu
   7. Amalia Papanikolaou
   8. Fabio R. Rodrigues
   9. Thomas Wheatcroft
   10. Stefano Zucca
   11. Samuel G. Solomon
   12. Aman B. Saleem

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Increasingly, neuroscience experiments require immersive virtual environments that approximate natural sensory motor loops while permitting high-bandwidth measurements of brain activity. BonVision is an open-source graphics programming library that allows experimenters to quickly implement immersive 3D visual environments across display hardware and geometry with automated calibration and integration with hundreds of different neural recording technologies, behavioral apparatuses, etc. BonVision standardizes sharing complex, closed-loop visual tasks between labs with vastly different equipment, provides a concrete and easy way to do so, and should be of interest to a wide array of visual systems neuroscientists.

   Reviewed by eLife

2. GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

   This article has 4 authors:

   1. Marissa M Gaskill
   2. Tyler J Gibson
   3. Elizabeth D Larson
   4. Melissa M Harrison

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to a broad audience of developmental biologists and molecular biologists in the field of transcriptional control and epigenetics. It evaluates the pioneer factor activity associated with GAGA-Factor during the process of zygotic genome activation. The experiments are rigorously performed and the data analysis supports the conclusions.

     This manuscript is in revision at eLife.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors)

   Reviewed by eLife

3. Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate

   This article has 16 authors:

   1. Benjamin Amoah
   2. Robert S McCann
   3. Alinune N Kabaghe
   4. Monicah Mburu
   5. Michael G Chipeta
   6. Paula Moraga
   7. Steven Gowelo
   8. Tinashe Tizifa
   9. Henk van den Berg
   10. Themba Mzilahowa
   11. Willem Takken
   12. Michele van Vugt
   13. Kamija S Phiri
   14. Peter J Diggle
   15. Dianne J Terlouw
   16. Emanuele Giorgi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The association between metrics of malaria transmission based on prevalence of existing infections and the incidence of new infections has epidemiologically important consequences for malaria control and elimination efforts. The association between P. falciparum entomological inoculation rate and parasite prevalence has been previously characterized, and this report evaluates the added-value of spatio-temporal models to such analyses.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

4. Unsupervised learning of haptic material properties

   This article has 2 authors:

   1. Anna Metzger
   2. Matteo Toscani

   Reviewed by eLife

5. Heritable functional architecture in human visual cortex

   This article has 6 authors:

   1. Ivan Alvarez
   2. Nonie J. Finlayson
   3. Shwe Ei
   4. Benjamin de Haas
   5. John A. Greenwood
   6. D. Samuel Schwarzkopf

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The paper was viewed as generally sound. There main concern was that the findings were viewed as incremental without a demonstration of a link between the heritability of pRF properties and visual perception. The speculation in the Discussion about shared perceptual experience is intriguing, but psychophysical (or other) evidence would be needed to really make that point clearly. In addition, there was some discussion about the non-independence of vertices and correlation values. In the end, we all agreed that non-independent vertices may inflate correlation coefficient values, but that this is unlikely to substantially affect conclusions drawn from comparisons of monozygotic and dizygotic twins.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. Subjective time is predicted by local and early visual processing

   This article has 4 authors:

   1. Yelena Tonoyan
   2. Michele Fornaciai
   3. Brent Parsons
   4. Domenica Bueti

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This work uses electro-encephalographic (EEG) recordings combined with an interesting experimental approach to measure temporal expansion/compression. Specifically, the question addressed here is whether adaptation to visual motion affects perceived duration, and if so, how spatially confined these effects are with respect to the processing of the stimulus in early visual areas. The authors find consistent evidence that a visual reference is judged as shorter/longer depending on a previous adaptation. They report several EEG analyses suggesting the early visual activity is correlated with such temporal distortions. This manuscript is of potential interest to cognitive neuroscientists specifically interested in temporal aspects of visual processing and time perception. Although the paradigm is well suited to assess the authors' question, the behavioral data as well as the electrophysiological analyses show important shortcomings currently hindering the interpretation of the results, and necessitating substantial revisions to the current work. Additionally, further methodological details are required to strengthen the manuscript.

   Reviewed by eLife

7. Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

   This article has 17 authors:

   1. Parastoo Boroumand
   2. David C Prescott
   3. Tapas Mukherjee
   4. Philip J Bilan
   5. Michael Wong
   6. Jeff Shen
   7. Ivan Tattoli
   8. Yuhuan Zhou
   9. Angela Li
   10. Tharini Sivasubramaniyam
   11. Nancy Shi
   12. Lucie Y Zhu
   13. Zhi Liu
   14. Clinton Robbins
   15. Dana J Philpott
   16. Stephen E Girardin
   17. Amira Klip

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Using mice fed with high fat diet (HFD), Boroumand et al. observed a link between bone marrow (BM) adipocyte whitening and the expansion of BM Ly6Chi monocytes and derived cells in the adipose tissue. By adopting an in vitro approach, they also show that BM conditioned medium is able to metabolically rewire Ly6Chi monocytes notably concerning mitochondrial fission/fusion gene expression. They conclude that early changes in the BM adipocytes induced by HFD drive the activation of monocytes and influence the outcome of the disease.

     This study is of interest to those investigating BM adaptations to lipid signals as well as macrophage biologists interested in macrophage recruitment and differentiation in the context of obesity and beyond in inflammation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors)

   Reviewed by eLife

8. An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

   This article has 11 authors:

   1. Rediet Zewdu
   2. Elnaz Mirzaei Mehrabad
   3. Kelley Ingram
   4. Pengshu Fang
   5. Katherine L Gillis
   6. Soledad A Camolotto
   7. Grace Orstad
   8. Alex Jones
   9. Michelle C Mendoza
   10. Benjamin T Spike
   11. Eric L Snyder

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript greatly expands our understanding of an aggressive subtype of lung cancer. The author use in vivo cancer models and extensive analysis of the cancer cells states to uncover aspects of differentiation, drug responses and pathway activation. Findings of the study will help in the development of lineage-specific targeted therapies against cancers.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife, preLights

9. Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

   This article has 11 authors:

   1. Sebastian Hückesfeld
   2. Philipp Schlegel
   3. Anton Miroschnikow
   4. Andreas Schoofs
   5. Ingo Zinke
   6. André N Haubrich
   7. Casey M Schneider-Mizell
   8. James W Truman
   9. Richard D Fetter
   10. Albert Cardona
   11. Michael J Pankratz

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will be of broad interest to readers in the field of neuroscience. The authors use a serial section transmission electron microscopy data set to trace out the entire neuroendocrine system of a maggot from its sensory input to neuroendocrine cells. It highlights the complexity of brain circuits, describing how parallel processing systems can lead to a multitude of different input combinations for different neuroendocrine cell types and subcircuits. They provide interpretations about functionality of one of described neural circuits. While the analyses are generally rigorous, the functional interpretations need more supporting evidence.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

10. Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

    This article has 9 authors:

    1. Jesse R Holt
    2. Wei-Zheng Zeng
    3. Elizabeth L Evans
    4. Seung-Hyun Woo
    5. Shang Ma
    6. Hamid Abuwarda
    7. Meaghan Loud
    8. Ardem Patapoutian
    9. Medha M Pathak

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The manuscript links a critical physiological function of the skin, wound healing to the ability of skin cells to migrate and the modification of migration by the mechanosensitive ion channel Piezo1. The topic of the manuscript is timely, relevant and would be of interest to a broad audience. The experimental design followed by the authors is straightforward and elegant, and the majority of the conclusions are well supported by the results.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife