eLife

Latest preprint reviews

1. Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala

   This article has 11 authors:

   1. Vijay K Samineni
   2. Jose G Grajales-Reyes
   3. Gary E Grajales-Reyes
   4. Eric Tycksen
   5. Bryan A Copits
   6. Christian Pedersen
   7. Edem S Ankudey
   8. Julian N Sackey
   9. Sienna B Sewell
   10. Michael R Bruchas
   11. Robert W Gereau

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work will be of general interest to neuroscientists, especially those studying how the brain processes itch stimuli and controls itch-related behavior. The authors show that specific cells in the central amygdala (and their communication with other parts of the brain) play an important role in itching (pruritic) behavior. Overall, the authors provides several lines of evidence to support their conclusions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

2. Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

   This article has 5 authors:

   1. Tilman Stephani
   2. Alice Hodapp
   3. Mina Jamshidi Idaji
   4. Arno Villringer
   5. Vadim V Nikulin

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Stephani et al. address the question of how ongoing fluctuations in neuronal excitability, as well as stimulus strength, impact the perception of above-threshold tactile stimuli and the subsequent stimulus-evoked brain activity. The results are puzzling in an interesting way, and while the authors provide a nicely parsimonious explanation rooted in the underlying neurophysiology, editors and reviewers think this study has the potential to further motivate many lines of investigation. This manuscript will be of interest mainly to researchers using electrophysiological methods (EEG, MEG, ECoG etc.), as the authors have produced a very high-quality EEG data-set (including uncommon peripheral measurements).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

3. Quantitative mapping of human hair greying and reversal in relation to life stress

   This article has 12 authors:

   1. Ayelet M Rosenberg
   2. Shannon Rausser
   3. Junting Ren
   4. Eugene V Mosharov
   5. Gabriel Sturm
   6. R Todd Ogden
   7. Purvi Patel
   8. Rajesh Kumar Soni
   9. Clay Lacefield
   10. Desmond J Tobin
   11. Ralf Paus
   12. Martin Picard

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an interesting and informative study reporting on the molecular features of reversible hair graying in humans and the connection with psychological stress. The study appears to have been very well conducted and the interpretations are generally supported by the data. While the results are primarily correlative at this stage, this work will set the stage for future more mechanistic studies and represents an important conceptual and methodological advance.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife, preLights

4. Physiology and ecology combine to determine host and vector importance for Ross River virus

   This article has 5 authors:

   1. Morgan P Kain
   2. Eloise B Skinner
   3. Andrew F van den Hurk
   4. Hamish McCallum
   5. Erin A Mordecai

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript outlines an epidemiological framework to investigate the relative contribution of different hosts and vectors to the initial spread of a zoonotic disease. It focuses on Ross River virus in Brisbane and collates previously published estimates of abundance, biometrics and viral profiles to highlight the most epidemiologically important routes of transmission.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

5. Mapping single-cell atlases throughout Metazoa unravels cell type evolution

   This article has 7 authors:

   1. Alexander J Tarashansky
   2. Jacob M Musser
   3. Margarita Khariton
   4. Pengyang Li
   5. Detlev Arendt
   6. Stephen R Quake
   7. Bo Wang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The development of single-cell genomic methods has transformed our understanding of cell types and their attributes across organisms. Here, Tarashansky et al develop SAMap (Self-Assembling Manifold mapping), a graph-based data integration method which builds upon their previously described SAM algorithm to facilitate assignment of homologous genes and cell types across diverse species. As the authors show, this empowers comparative analyses across phyla to facilitate cellular annotation and examine the evolutionary origins of cellular diversity. Overall, the manuscript is well-written and the algorithm has the potential to be foundation for comparative cellular atlasing.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. The structural connectome constrains fast brain dynamics

   This article has 10 authors:

   1. Pierpaolo Sorrentino
   2. Caio Seguin
   3. Rosaria Rucco
   4. Marianna Liparoti
   5. Emahnuel Troisi Lopez
   6. Simona Bonavita
   7. Mario Quarantelli
   8. Giuseppe Sorrentino
   9. Viktor Jirsa
   10. Andrew Zalesky

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The present paper addresses the relationship between the electrophysiological and the anatomical connectomes, utilising a method to describe avalances of activity. The editors feel that this work might be pushing the limits of MEG as a modality, since it implies more spatial precision that most would assume possible, which makes the manuscript particularly interesting to M/EEG researchers. While all reviewers agree that the paper has broad interest and the method is promising, some potential concerns have however been raised that compromise the validity of the results. Most importantly: the issue of volume conduction (proximity) driving the results as opposed to anatomical connectivity, which in the worst case could deemed the results trivial. Other confounds, such as the size of the parcels and their SNR, would also require major review.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

7. Genomic basis of drought resistance in Fagus sylvatica

   This article has 14 authors:

   1. Markus Pfenninger
   2. Friederike Reuss
   3. Angelika Kiebler
   4. Philipp Schönnenbeck
   5. Cosima Caliendo
   6. Susanne Gerber
   7. Berardino Cocchiararo
   8. Sabrina Reuter
   9. Nico Blüthgen
   10. Karsten Mody
   11. Bagdevi Mishra
   12. Miklós Bálint
   13. Marco Thines
   14. Barbara Feldmeyer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study uses a genome-wide association approach combining pool-seq data with whole-genome resequencing, which provides a cost-effective means to scale genome-wide association studies to a larger number of individuals, to dissect the genetic basis of drought resistance in several German populations of European beech. European beech is an ecologically important forest tree species and drought resistance is a trait that is likely to be becoming increasingly relevant to the survival of these trees as climate change leads to more frequent and prolonged periods of drought. Knowledge of the genetic basis of such variation existing within current populations can help with management of those populations in the face of increasing threats, especially when such information is used to develop tools for predicting individuals that are likely to have the highest chances of survival, and to suggest hypotheses regarding traits and genetic material which will be important for the future of forests.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

8. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

   This article has 12 authors:

   1. Shintaro Ide
   2. Yoshihiko Kobayashi
   3. Kana Ide
   4. Sarah A Strausser
   5. Koki Abe
   6. Savannah Herbek
   7. Lori L O'Brien
   8. Steven D Crowley
   9. Laura Barisoni
   10. Aleksandra Tata
   11. Purushothama Rao Tata
   12. Tomokazu Souma

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Ferroptotic cell death underlies tissue dysfunction inflicted by transient ischemia/reperfusion particularly in renal tissue. Here, the authors provide experimental evidence in animal models and human biopsies that mild and severe ischemic stress trigger distinctive cellular responses in proximal tubular cells which decide upon whether or not tissue may regenerate or fail. This is further corroborated in a genetic mouse model with mild ischemic stress-induced ablation of the key ferroptosis regulator glutathione peroxidase 4 (GPX4). These studies will be of significant interest both to those studying acute kidney injury and others interested in ischemic injury in other organ systems.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

9. Spc1 regulates substrate selection for signal peptidase

   This article has 6 authors:

   1. Chewon Yim
   2. Yeonji Chung
   3. Jeesoo Kim
   4. IngMarie Nilsson
   5. Jong-Seo Kim
   6. Hyun Kim

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This interesting and well-executed work addresses the function of one of the subunits of the signal peptidase, a complex that processes signal peptides in a wide variety of secretory and membrane proteins. This topic is of relevance to the membrane cell biology community, and the study will be of broader interest when the authors demonstrate the relevance of their findings to the natural substrates of the studied enzyme.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

10. Method development and characterisation of the low-molecular-weight peptidome of human wound fluids

    This article has 6 authors:

    1. Mariena JA van der Plas
    2. Jun Cai
    3. Jitka Petrlova
    4. Karim Saleh
    5. Sven Kjellström
    6. Artur Schmidtchen

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This well-done study establishes a work flow for the analysis of the peptidome of wound fluids. By doing so it enables the identification of peptide patterns associated with wounds that are healing versus non-healing. The method may therefore help to define candidate biomarkers for wound healing. Overall enthusiasm was somewhat dampened by findings previously reported by the same group and also by others.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife