eLife

Latest preprint reviews

1. The E3 ubiquitin ligase mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation

   This article has 6 authors:

   1. Vishnu Muraleedharan Saraswathy
   2. Akshai Janardhana Kurup
   3. Priyanka Sharma
   4. Sophie Polès
   5. Morgane Poulain
   6. Maximilian Fürthauer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript describes a novel role of the E3 ubiquitin ligase Mindbomb1 (Mib1), a known key regulator of Notch signaling, in regulating convergent extension movements of the zebrafish gastrula, which are dependent on planar cell polarity (PCP) signaling. The authors show that the ability of Mib1 to modulate PCP is totally dependent on the receptor tyrosine kinase Ryk via endocytosis. This paper will be of interest to scientists studying cell signaling and cell movement.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

   This article has 17 authors:

   1. Pinxiu Huang
   2. Wenbo Deng
   3. Haili Bao
   4. Zhong Lin
   5. Mengying Liu
   6. Jinxiang Wu
   7. Xiaobo Zhou
   8. Manting Qiao
   9. Yihua Yang
   10. Han Cai
   11. Faiza Rao
   12. Jingsi Chen
   13. Dunjin Chen
   14. Jinhua Lu
   15. Haibin Wang
   16. Aiping Qin
   17. Shuangbo Kong

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Huang et al have identified SOX4 as a key regulatory factor that controls prolactin and FOXO1 transcription factor which in turn regulate decidualization, an important process in embryo development. Further, they have identified that SOX4 also regulates progesterone receptor and dysregulated SOX4-progesterone and ubiquitin ligase HERC4can lead to embryo implantation failure thus explaining the molecular basis of recurrent implantation failure in humans. Overall the study is interesting and the data are very strong. Some concerns noted were the use of immortalized stromal cells, and incomplete nature of studies with human endometrial stroll cells from endometriosis patients, and lack of sufficient discussion in some parts of the text, and whether specific progesterone isofoms are involved downstream of SOX4.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain

   This article has 15 authors:

   1. Elizabeth L Wagner
   2. Jun-Sub Im
   3. Stefano Sala
   4. Maura I Nakahata
   5. Terence E Imbery
   6. Sihan Li
   7. Daniel Chen
   8. Katherine Nimchuk
   9. Yael Noy
   10. David W Archer
   11. Wenhao Xu
   12. George Hashisaki
   13. Karen B Avraham
   14. Patrick W Oakes
   15. Jung-Bum Shin

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study investigates a process by which hair cell stereocilia, the sensory structures that respond to sound in the hearing organ and to head motion or tilt in the vestibular organ, can recover from damage-induced gaps in their actin core, possibly allowing for the rescue of transient hearing loss after exposure to noise. This manuscript will be of strong interest to the inner ear field as well as readers with broader interest in actin cytoskeleton dynamics. Although meticulous controls, a combination of molecular, histological and functional studies and an innovative mouse model generally support the major conclusions of this study, additional controls are needed to confirm the mechanistic claims made in the manuscript.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

4. An entropic safety catch controls hepatitis C virus entry and antibody resistance

   This article has 16 authors:

   1. Lenka Stejskal
   2. Mphatso D Kalemera
   3. Charlotte B Lewis
   4. Machaela Palor
   5. Lucas Walker
   6. Tina Daviter
   7. William D Lees
   8. David S Moss
   9. Myrto Kremyda-Vlachou
   10. Zisis Kozlakidis
   11. Giulia Gallo
   12. Dalan Bailey
   13. William Rosenberg
   14. Christopher JR Illingworth
   15. Adrian J Shepherd
   16. Joe Grove

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     HCV is unique in its glycoprotein structure, complex receptor usage and its unusual persistence for a (+)RNA virus. This is a well done study that explains a number of observations regarding receptor usage and how HCV may evade antibody control via HVR1 due to its disordered nature, enable mutation to continually evade antibody responses. This manuscript should be of substantial interest to those in the fields of virus entry, vaccination against human viruses, and the study of how intrinsically disordered regions can play regulatory roles.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. Widespread nociceptive maps in the human neonatal somatosensory cortex

   This article has 8 authors:

   1. Laura Jones
   2. Madeleine Verriotis
   3. Robert J Cooper
   4. Maria Pureza Laudiano-Dray
   5. Mohammed Rupawala
   6. Judith Meek
   7. Lorenzo Fabrizi
   8. Maria Fitzgerald

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to developmental neuroscientists who study the early stages of cortical maturation and specialization, particularly in the context of somatosensory and pain system development. The authors suggest that, relative to the infant touch somatotopic map, the infant nociceptive map is more widespread and poorly localised, consistent with infants' poorly directed pain behaviour. However, there are differences in the the implementation of touch and pain conditions and concerns around the analyses that limit support for this interpretation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

   This article has 6 authors:

   1. Seyi Falekun
   2. Jaime Sepulveda
   3. Yasaman Jami-Alahmadi
   4. Hahnbeom Park
   5. James A Wohlschlegel
   6. Paul A Sigala

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study defines the role of a divergent mitochondrial-localized isoform of a FASII acyl carrier protein (mACP) in the malaria parasite, Plasmodium falciparum. In contrast to the situation in other eukaryotes, mACP is not involved in fatty acid biosynthesis, but is primarily involved in stabilizing proteins involved in mitochondrial Fe-S complex formation. Analysis of mACP function in these protists indicates that ACP acquired a role in Fe-S complex formation early in eukaryotic evolution and highlights additional components of the Plasmodium respiratory chain that are important for viability.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

7. Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling

   This article has 21 authors:

   1. Joseph D Butner
   2. Geoffrey V Martin
   3. Zhihui Wang
   4. Bruna Corradetti
   5. Mauro Ferrari
   6. Nestor Esnaola
   7. Caroline Chung
   8. David S Hong
   9. James W Welsh
   10. Naomi Hasegawa
   11. Elizabeth A Mittendorf
   12. Steven A Curley
   13. Shu-Hsia Chen
   14. Ping-Ying Pan
   15. Steven K Libutti
   16. Shridar Ganesan
   17. Richard L Sidman
   18. Renata Pasqualini
   19. Wadih Arap
   20. Eugene J Koay
   21. Vittorio Cristini

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript one novel model was constructed to be predictive of cancer immunotherapy based on three parameters proposed to be associated with treatment efficacy. The parameters are easy to fetch under the clinical setting, so the model is simple for application to help predict potential patients who would benefit from immunotherapy.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Standardizing workflows in imaging transcriptomics with the abagen toolbox

   This article has 6 authors:

   1. Ross D Markello
   2. Aurina Arnatkeviciute
   3. Jean-Baptiste Poline
   4. Ben D Fulcher
   5. Alex Fornito
   6. Bratislav Misic

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to scientists studying the large-scale transcriptomic organization of the human brain, and in particular those who have used or plan to use the Allen Human Brain Atlas dataset. The study is well-motivated and novel. The most striking finding is the magnitude of variability that is introduced by different data-processing decisions. The open-source software described in this study is an important contribution to the field and will be of broad utility.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. Cell-type-specific responses to associative learning in the primary motor cortex

   This article has 5 authors:

   1. Candice Lee
   2. Emerson F Harkin
   3. Xuming Yin
   4. Richard Naud
   5. Simon Chen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Using advanced live brain imaging techniques, the authors studied the activities of neurons in the primary motor cortex of mice during a classical conditional task, in which a tone is paired with water reward. They found that distinct types of neurons respond differently to the auditory cue or the reward, and the responses evolve differentially as learning proceeds. This work reveals an interesting role of the motor cortex beyond its well-recognized function in motor control, and suggests distinct functions of pyramidal neurons as well as various interneurons in reinforcement learning.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

10. Desmosomal connectomics of all somatic muscles in an annelid larva

    This article has 7 authors:

    1. Sanja Jasek
    2. Csaba Verasztó
    3. Emelie Brodrick
    4. Réza Shahidi
    5. Tom Kazimiers
    6. Alexandra Kerbl
    7. Gáspár Jékely

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper is based on digital reconstruction of a serial EM stack of a larva of the annelid Platynereis and presents a complete 3D map of all desmosomes between somatic muscle cells and their attachment partners. This resource is of interest to scientists in several fields: motor control, high-resolution anatomy, and network analyses. With the first comprehensive and complete mapping of muscle-to-body connectivity through desmosomes in an annelid larva, it has the potential to close a missing link and make progress towards understanding in a "holistic" way how a complex neural circuitry controls an equally complex pattern of movement/behavior.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife