eLife

Latest preprint reviews

1. Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle

   This article has 19 authors:

   1. Yibo Fan
   2. Senuri De Silva
   3. Nishat I Tabassum
   4. Xiangyuan Peng
   5. Vernise JT Lim
   6. Xiangru Cheng
   7. Keshava K Datta
   8. Rohan Lowe
   9. Terrance G Johns
   10. Mark P Mattson
   11. Suresh Mathivanan
   12. Christopher G Sobey
   13. Eitan Okun
   14. Yong U Liu
   15. Guobing Chen
   16. Mitchell Kim Peng Lai
   17. Dong-Gyu Jo
   18. Jayantha Gunaratne
   19. Thiruma V Arumugam

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a solid paper on intermittent fasting that will be of interest to readers. The data presented are certainly valuable as a resource. The findings of both shared and tissue-specific signatures, both at the proteomic and transcriptomic levels, align well with what has been established and bring new insight into metabolic adaptation and its consequences in muscle, cortex, and liver. The organ specific changes unveiled by proteomics in response to IF reveal unique rewiring of metabolic, signaling and physiological function.

   Reviewed by eLife

2. Cognitive simplicity drives collective route improvements in homing pigeons

   This article has 3 authors:

   1. Shoubhik Chandan Banerjee
   2. Fritz A Francisco
   3. Albert B Kao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study addresses an important question and shows how social navigation in homing pigeons can be explained by simple averaging, without requiring any complex cognitive abilities. The evidence, based on a rigorous and systematic comparison of seven models and data on how social routes can be generated from solitary routes, is compelling. The authors should be commended for their willingness to critically re-examine established interpretations.

   Reviewed by eLife

3. Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity

   This article has 6 authors:

   1. Katrina M Zinn
   2. Mathew W McLaren
   3. Michael T Imai
   4. Malavika M Jayaram
   5. Jeffery D Rothstein
   6. Matthew J Elrick

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study examines the cleavage of motor neuron nucleoporins by proteases of enterovirus D68, a pathogen associated with acute flaccid myelitis. The evidence supporting the effects of EV-D68 proteases on nuclear import and export is generally solid, as is the independent examination of EV-D68 protease on spinal cord neuron toxicity. The specific conclusions related to RNA export were considered overstated relative to the data presented.

   Reviewed by eLife

4. Multiple event segmentation mechanisms in the human brain

   This article has 4 authors:

   1. Tan T Nguyen
   2. Joset A Etzel
   3. Matthew A Bezdek
   4. Jeffrey M Zacks

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study tests whether prediction error or prediction uncertainty controls how the brain segments continuous experience into events. The paper uses validated models that predict human behavior to analyze multivariate neural pattern changes during naturalistic movie watching. The authors provide solid evidence that there are overlapping but partially distinct brain dynamics for each signal.

   Reviewed by eLife

5. The age and sex dynamics of heterosexual HIV transmission in Zambia: an HPTN 071 (PopART) phylogenetic and modelling study

   This article has 27 authors:

   1. Matthew D Hall
   2. William Probert
   3. Lucie Abeler-Dörner
   4. Chris Wymant
   5. Francesco di Lauro
   6. Xiayoue Xi
   7. Rafael Sauter
   8. Tanya Golubchik
   9. David Bonsall
   10. Michael Pickles
   11. Anne Cori
   12. Justin Bwalya
   13. Sian Floyd
   14. Nomtha Bell-Mandla
   15. Kwame Shanaube
   16. Blia Yang
   17. Peter Bock
   18. Deborah Donnell
   19. Mary K Grabowski
   20. Deenan Pillay
   21. Andrew Rambaut
   22. Oliver Ratmann
   23. Sarah Fidler
   24. Helen Ayles
   25. Richard Hayes
   26. Christophe Fraser
   27. the PANGEA-HIV consortium and the HPTN 071 (PopART) study team

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides evidence for our understanding of HIV transmission dynamics by age and sex in Zambia during the PopART trial; by combining phylogenetic and individual-based mathematical modelling (IBM), it adds depth to the epidemiological literature and may inform more strategic allocation of HIV prevention resources in sub-Saharan Africa. The authors employ two complementary and well-established methodologies (phylogenetics and IBM), and this dual approach is a notable strength. However, the evidence supporting key conclusions is incomplete, with several claims insufficiently substantiated by the data presented. Improvements in data presentation (e.g., quantification of qualitative statements, statistical estimates, and clearer description of results) would substantially strengthen the paper.

   Reviewed by eLife

6. RadD from Fusobacterium nucleatum engages NKp46 to promote antitumor cytotoxicity

   This article has 8 authors:

   1. Ahmed Rishiq
   2. Johanna Galaski
   3. Reem Bsoul
   4. Mingdong Liu
   5. Rema Darawshe
   6. Renate Lux
   7. Gilad Bachrach
   8. Ofer Mandelboim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study describes a mechanism of microbial modulation of anti-tumor immunity, which is of considerable interest in the field. However, the experimental supports for the key mechanistic claim, the interaction between RadD and NKp46, are not robust. Multiple experimental inconsistencies, especially in vivo, weaken the conclusions, making the strength of evidence incomplete. Additional controls, direct binding assays, and clarification of in vivo mechanistic relevance would strengthen the work.

   Reviewed by eLife

7. Inverted Assembly of the Lens Within Ocular Organoids Reveals Alternate Paths to Ocular Morphogenesis

   This article has 6 authors:

   1. Elin Stahl
   2. Miguel Angel Delgado-Toscano
   3. Ishwariya Saravanan
   4. Anastasija Paneva
   5. Joachim Wittbrodt
   6. Lucie Zilova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that ocular organoids can generate both retina and lens through a non-canonical, "inside-out" morphogenetic route. The work is supported by convincing data, with well-designed experiments combining imaging, molecular analysis, and transcriptomics to establish that lens formation in organoids follows conserved molecular programs despite an alternative morphogenesis. These findings expand our understanding of self-organization and developmental plasticity, and will be of broad interest to researchers working on eye development, organoids, and tissue engineering.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

8. Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans

   This article has 5 authors:

   1. Muhammad Badarnee
   2. Zhenfu Wen
   3. B Isabel Moallem
   4. Stephen Maren
   5. Mohammed R Milad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the role of thalamic nuclei in associative threat and extinction learning, underpinned by a large dataset and rigorous, multipronged analyses. The evidence provided is solid, supporting the main conclusions. Minor analytical refinements notwithstanding, the manuscript will be of broad interest to researchers in learning and memory, fear, thalamic circuitry, and related mental health conditions.

   Reviewed by eLife

9. Controlling the synchronization and symmetry breaking of coupled bacterial pili on active biofilm carpets

   This article has 11 authors:

   1. Baha Altın
   2. Enes Talha Günay
   3. İlker Yusuf Yaman
   4. Alp Ünlü
   5. Yiğithan Gediz
   6. Neslihan Gedik
   7. Bora Karataş
   8. Mustafa Başaran
   9. Coşkun Kocabaş
   10. Şahin Kaya Özdemir
   11. Askin Kocabas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study concerns the propagation of waves in bacterial biofilms, bridging active matter physics and bacterial biophysics. While the experimental observations are solid, the theoretical interpretation and model validation are currently incomplete and require further refinement. This work will be of interest to microbiologists, biophysicists, and researchers studying collective behavior in biological systems.

   Reviewed by eLife

10. Perceptual glimpses are locally accumulated and globally maintained at distinct processing levels

    This article has 4 authors:

    1. Elisabeth Parés-Pujolràs
    2. Anna C Geuzebroek
    3. Redmond G O’Connell
    4. Simon P Kelly

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents valuable findings on the physiological and computational underpinnings of the accumulation of intermittent glimpses of sensory evidence. The evidence supporting the claims of the authors is solid, although a more exhaustive characterisation of how the different signals interact would have strengthened the study. The work will be of interest to cognitive and systems neuroscientists working on decision-making.

    Reviewed by eLife