Latest preprint reviews

  1. Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

    This article has 14 authors:
    1. Miles R Bryan
    2. Michael F Almeida
    3. Kyle Pellegrino
    4. Carli K Opland
    5. J Ethan Paulakonis
    6. Jake McGillion-Moore
    7. Hanna Trzeciakiewicz
    8. Diamond King
    9. Xu Tian
    10. Jui-Heng Tseng
    11. Jonathan C Schisler
    12. Nicholas G Brown
    13. Ben A Bahr
    14. Todd J Cohen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents compelling new data that combine two FTD-tau mutations, P301L/S320F (PL-SF), that reliably induce spontaneous full-length tau aggregation across multiple cellular systems. The findings are important for the field of neurodegenerative disease. The strength of evidence is solid; however, several conclusions would benefit from more validation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Emergence of Functional Heart-Brain Circuits in a Vertebrate

    This article has 11 authors:
    1. Luis Hernandez-Nunez
    2. Joana Avrami
    3. Sky Shi
    4. Areni Markarian
    5. Annette Kim
    6. Jonathan Boulanger-Weill
    7. Virginia Rutten
    8. Arman Zarghani-Shiraz
    9. Misha B Ahrens
    10. Florian Engert
    11. Mark C Fishman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important manuscript, the authors establish a vertebrate model for studying the development of circuits that control heart rate. This contribution uses a combination of experimental techniques to provide compelling information for scientists looking to understand how heart rate regulation emerges during development.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Intersection of transient cell states with stable cell types in hippocampus

    This article has 3 authors:
    1. Jack A Olmstead
    2. Lauren E King
    3. Brenda L Bloodgood
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides a detailed analysis of the transcriptional landscape of the mouse hippocampus in the context of various physiological states. The main conclusions have solid support: that most transcriptional targets are generally stable, with notable exceptions in the dentate gyrus and with regard to circadian changes. There are some weaknesses and it would improve the manuscript to address them.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Maximized field-of-view deep-brain calcium imaging through gradient-index lenses

    This article has 5 authors:
    1. Chenmao Wang
    2. Zongyue Cheng
    3. Yuting Li
    4. Jianian Lin
    5. Meng Cui
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable and practical approach for one-photon imaging through GRIN lenses. By scanning a low numerical aperture (NA) beam and collecting fluorescence with a high NA, the method expands the usable field of view and yields clearer cellular signals. The evidence is solid overall, with strong qualitative demonstrations, but some claims would benefit from additional quantitative tests. The work will interest researchers who need simple, scalable tools for large‑area cellular imaging in the brain.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Voltage imaging reveals the emergence of population activity in the spinal cord

    This article has 6 authors:
    1. Asuka Shiraishi
    2. Ayane Hayashi
    3. Narumi Fukuda
    4. Mari Hishinuma
    5. Hiroaki Miyazawa
    6. Sachiko Tsuda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper presents an important advance in genetically encoded voltage imaging of the developing zebrafish spinal cord in vivo, capturing voltage dynamics in neuronal populations, single cells, and subcellular compartments inaccessible to patch clamp, and diverse spike waveforms and subthreshold voltage dynamics inaccessible to calcium imaging. The work identifies a developmental progression from irregular voltage fluctuations to coordinated contralateral and ipsilateral activity, providing insight into how electrical dynamics and cellular morphology evolve during circuit formation. The strength of evidence is solid, with imaging data supporting the main conclusions, although the manuscript would be strengthened by more complete methodological documentation and clearer context relative to earlier calcium imaging studies. Overall, this study provides a resource that is of importance for researchers investigating neural development and circuit assembly, illustrating the value of voltage imaging as a general tool for probing bioelectric mechanisms in morphogenesis and circuit development.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. RETRACTED: Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

    This article has 14 authors:
    1. Hanwen Chen
    2. Tian Xiong
    3. Baoxing Guan
    4. Jiaqi Huang
    5. Danrui Zhao
    6. Yao Chen
    7. Haoran Liang
    8. Yingwei Li
    9. Jingwen Wu
    10. Shaoping Ye
    11. Ting Li
    12. Wensheng Shu
    13. Jin-tian Li
    14. Yutao Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides important evidence that myristate, a fatty acid commonly present in soil environments, is taken up by arbuscular mycorrhizal fungi during symbiosis with a plant host. The evidence presented is solid, with multiple experimental approaches including stable isotope tracing, transcriptional analysis, and physiological measurements across different plant species and phosphorus conditions. However, the main claims are only partially supported.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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