eLife

Latest preprint reviews

1. Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

   This article has 7 authors:

   1. Hiroki Toyoda
   2. Doyun Kim
   3. Byeong Geon Koh
   4. Tomomi Sano
   5. Takashi Kanematsu
   6. Seog Bae Oh
   7. Youngnam Kang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study explores a novel cellular mechanism underlying the degeneration of locus coeruleus neurons during chronic restraint stress. The evidence supporting the overexcitation of LC neurons after chronic stress is compelling. The topic is timely, the proposed mechanistic pathway is innovative, and the findings have translational relevance, particularly regarding therapeutic strategies targeting α2A-AR internalization in neurodegenerative diseases.

   Reviewed by eLife

2. Making plant tissue accessible for cryo-electron tomography

   This article has 19 authors:

   1. Matthias Pöge
   2. Marcel Dickmanns
   3. Peng Xu
   4. Meijing Li
   5. Oda H Schiøtz
   6. Christoph OJ Kaiser
   7. Jianfei Ma
   8. Anna Bieber
   9. Cristina Capitanio
   10. Johann Brenner
   11. Margot Riggi
   12. Sven Klumpe
   13. Manuel Miras
   14. Neda S Kazemein Jasemi
   15. Waltraud X Schulze
   16. Rüdiger Simon
   17. Wolf B Frommer
   18. Jürgen M Plitzko
   19. Wolfgang Baumeister

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Thick multicellular plant samples provide unique challenges when it comes to cryo-preservation, which has resulted in limited successful examples for structural studies using in situ cryo-electron tomography. To address this deficiency, this important study describes procedures for high-pressure-freezing, focused ion-beam milling, and cryo-electron tomography imaging of certain plant types. The results described in the paper provide solid evidence for the usefulness of the methods described, although some reservations remain about the applicability of the methods to a wider range of plant cell types.

   Reviewed by eLife

3. Correlation detection as a stimulus computable account for audiovisual perception, causal inference, and saliency maps in mammals

   This article has 1 author:

   1. Cesare V Parise

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study evaluates a model for multisensory correlation detection, focusing on the detection of correlated transients in visual and auditory stimuli. Overall, the experimental design is sound and the evidence is compelling. The synergy between the experimental and theoretical aspects of the article is strong, and the work will be of interest to both neuroscientists and psychologists working in the domain of sensory processing and perception

   Reviewed by eLife

4. Cellular and synaptic organization of the Octopus vertical lobe

   This article has 5 authors:

   1. Flavie Bidel
   2. Yaron Meirovitch
   3. Fuming Yang
   4. Jeff William Lichtman
   5. Binyamin Hochner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study of the inhibitory complex amacrines (CAM) in the vertical lobe of Octopus vulgaris delivers a solid standard for the structural characterization of an anatomical region likely to be key for memory processing in this unconventional but complex organism, as well as a helpful classification of CAM subtypes. This work will be of broad relevance to the fields of memory and evolutionary neuroscience.

   Reviewed by eLife

5. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2307.12956v3

6. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2301.12812v6

7. The role of GABA in semantic memory and its neuroplasticity

   This article has 3 authors:

   1. JeYoung Jung
   2. Stephen Williams
   3. Matthew Lambon Ralph

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Jung et al. present valuable work on the relationship between gamma-aminobutyric acid (GABA) levels within the anterior temporal lobes (ATL) to semantic memory while accounting for inter-individual differences. They provide solid evidence suggesting that inhibitory continuous theta burst transcranial magnetic stimulation (cTBS TMS) increased GABA concentration and decreased the blood-oxygen dependent signal (BOLD) during a semantic task. The results will be of interest to researchers studying the neurobiology of semantic cognition.

   Reviewed by eLife

8. Genetic parallels in biomineralization of the calcareous sponge Sycon ciliatum and stony corals

   This article has 6 authors:

   1. Oliver Voigt
   2. Magdalena V Wilde
   3. Thomas Fröhlich
   4. Benedetta Fradusco
   5. Sergio Vargas
   6. Gert Wörheide

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper reports the discovery of calcarins, a protein family that seems to be involved in calcification in the calcareous sponge Sycon ciliatum, significantly enhancing our understanding of the molecular and cellular mechanisms underlying spicule formation in sponges and the evolution of carbonate biomineralization. The conclusions are supported by compelling evidence based on an integrated analysis that combines transcriptomics, genomics, proteomics, and precise in situ hybridization. These findings will be of broad interest to cell biologists, biochemists, and evolutionary biologists.

   Reviewed by eLife

9. Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

   This article has 27 authors:

   1. David Papadopoli
   2. Ranveer Palia
   3. Predrag Jovanovic
   4. Sébastien Tabariès
   5. Emma Ciccolini
   6. Valerie Sabourin
   7. Sebastian Igelmann
   8. Shannon McLaughlan
   9. Lesley Zhan
   10. HaEun Kim
   11. Nabila Chekkal
   12. Krzysztof J Szkop
   13. Thierry Bertomeu
   14. Jibin Zeng
   15. Julia Vassalakis
   16. Farzaneh Afzali
   17. Slim Mzoughi
   18. Ernesto Guccione
   19. Mike Tyers
   20. Daina Avizonis
   21. Ola Larsson
   22. Lynne-Marie Postovit
   23. Sergej Djuranovic
   24. Josie Ursini-Siegel
   25. Peter M Siegel
   26. Michael Pollak
   27. Ivan Topisirovic

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating that ETFDH suppression results in accumulation of amino acids that impact metabolism via hyperactive mTORC1.

   Reviewed by eLife

10. p66Shc Mediates SUMO2-induced Endothelial Dysfunction

    This article has 8 authors:

    1. Jitendra Kumar
    2. Shravan K Uppulapu
    3. Sujata Kumari
    4. Kanika Sharma
    5. William Paradee
    6. Ravi Prakash Yadav
    7. Vikas Kumar
    8. Santosh Kumar

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study offers valuable insights into the role of post-translational modifiers, specifically SUMO2ylation at K81 in p66Shc, and its impact on endothelial function through reactive oxygen species. A series of compelling experiments demonstrated that lysine 81 of p66Shc is the site of SUMO2 conjugation, which is crucial for mitochondrial localization and essential for S36 phosphorylation, leading to specific pathological effects. The combination of cell overexpression and animal studies provides solid data supporting this mechanistic link.

    Reviewed by eLife