eLife

Latest preprint reviews

1. Transcriptomic encoding of sensorimotor transformation in the midbrain

   This article has 20 authors:

   1. Zhiyong Xie
   2. Mengdi Wang
   3. Zeyuan Liu
   4. Congping Shang
   5. Changjiang Zhang
   6. Le Sun
   7. Huating Gu
   8. Gengxin Ran
   9. Qing Pei
   10. Qiang Ma
   11. Meizhu Huang
   12. Junjing Zhang
   13. Rui Lin
   14. Youtong Zhou
   15. Jiyao Zhang
   16. Miao Zhao
   17. Minmin Luo
   18. Qian Wu
   19. Peng Cao
   20. Xiaoqun Wang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This excellent manuscript combines molecular, anatomical and behavioral methods to characterize neuron types in the mouse superior colliculus. It will likely be a significant resource to those who study how these circuits integrate sensory information to promote motor output. A diverse set of experiments supports the conclusion that the superior colliculus includes separate circuit modules involved in distinct behaviors: prey capture and predator escape.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe

   This article has 5 authors:

   1. Ai Phuong S Tong
   2. Alex P Vaz
   3. John H Wittig
   4. Sara K Inati
   5. Kareem A Zaghloul

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study investigates the relationship between neuronal spiking and local field potential (LFP) activity recorded on micro-electrodes, and intracranial EEG activity recorded on macro-electrodes using a data from human patients with epilepsy. The dataset is rare and unique in that it is from the human brain and recording neural activity from multiple scales (single neuron, LFP, iEEG) within the same subjects. The study tackles important questions with regards to how ripples relate to broadband LFP activity as well as single neurons in the human brain. This results will be of interest to a broad audience of neuroscientists, and particularly to readers in the field of memory as well as those who perform electrophysiology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

   This article has 2 authors:

   1. Piotr Kolata
   2. Rouslan G Efremov

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript reports the cryoEM structure of a functional E. coli respiratory complex I (proton-pumping NADH-ubiquinone oxidoreductase) reconstituted in lipid nano-discs. The reconstructions and models presented by the authors indicate interesting E. coli specific features of the complex, although there are some concerns about model accuracy. Overall this can be a major advance for the structure of this important respiratory complex from a key model organism.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

4. A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

   This article has 14 authors:

   1. Anamaria Babosan
   2. David Skurnik
   3. Anaëlle Muggeo
   4. Gerald B Pier
   5. Zeynep Baharoglu
   6. Thomas Jové
   7. Marie-Cécile Ploy
   8. Sophie Griveau
   9. Fethi Bedioui
   10. Sébastien Vergnolle
   11. Sophie Moussalih
   12. Christophe de Champs
   13. Didier Mazel
   14. Thomas Guillard

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript describes how a small plasmid containing a quinolone resistance determinant changes the cellular response to sub-inhibitory concentrations of Tobramycin. Authors have found that Escherichia coli cells carrying this plasmid undergo nitrosative stress mediated by two previously uncharacterized genes, which leads to induction of the SOS response, a well described stress response in bacteria. These findings are relevant for readers across the microbiology and genetics fields.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

5. Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity

   This article has 4 authors:

   1. Alison F Feder
   2. Kristin N Harper
   3. Chanson J Brumme
   4. Pleuni S Pennings

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study considers how HIV evolutionary dynamics in a multiple drug-treated individual can give rise to the clinical patterns of the accrual of drug resistance mutations, including with understandings of the pharmacokinetics of the drugs in the body to help explain some of the patterns. The subject is of importance both clinically – for the optimal treatment choice for people living with HIV – and scientifically, due to the potential to predict and interpret evolutionary trajectories.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

6. Resonating neurons stabilize heterogeneous grid-cell networks

   This article has 2 authors:

   1. Divyansh Mittal
   2. Rishikesh Narayanan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a careful and systematic simulation study that convincingly illustrates a role for intrinsic resonance properties in suppressing the effects of cellular and network heterogeneities in a continuous attractor network model of grid cell firing patterns. The study shows that overly simplified models of neurons can lead to fragility in important network level behaviour and that intrinsic neuronal properties strongly influence relevant network level dynamics. This an important result that likely applies to a broad range of network models. Further investigation into the mechanism, possibly using a simplified model, would substantiate the simulation results and fully exploit the power of models in providing intuition and illustrating the generality of the observations.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Neural mechanisms of modulations of empathy and altruism by beliefs of others’ pain

   This article has 2 authors:

   1. Taoyu Wu
   2. Shihui Han

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This article represents a series of behavioral and imaging experiments investigating the effect of cognitive manipulation of beliefs on the explicit perception of other individual's pain and altruistic behavior. The results indicate that manipulations of people's beliefs regarding how much another person suffers alters the way participants rate the pain of others as well as the amount of money participants are willing to donate to the other person. Neuroimaging experiments, using EEG and fMRI, show that manipulating beliefs modulates neural activity in an early time window (P2 component) in response to the emotional expression of the other individual, involving temporo-parietal and medial frontal cortices. While there are some potential concerns about the novelty and implication of these findings, the results are overall clear and consistent throughout the six experiments, integrate with existing data, and are of broad interest to the researchers studying the neurobiology of empathy.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

   This article has 6 authors:

   1. Michael I Barton
   2. Stuart A MacGowan
   3. Mikhail A Kutuzov
   4. Omer Dushek
   5. Geoffrey John Barton
   6. P Anton van der Merwe

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of interest to virologists working on SARS-CoV-2, as well as biochemists and biophysicists who perform binding experiments with surface plasmon resonance (SPR), as it provides detailed affinity and kinetics analysis of the effect of mutations in variants of concern in the SARS-CoV-2 receptor binding domain with receptor ACE2 and two 'common' mutations in ACE2.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife, ScreenIT

9. Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

   This article has 12 authors:

   1. James P Bridges
   2. Caterina Safina
   3. Bernard Pirard
   4. Kari Brown
   5. Alyssa Filuta
   6. Ravichandran Panchanathan
   7. Rochdi Bouhelal
   8. Nicole Reymann
   9. Sejal Patel
   10. Klaus Seuwen
   11. William E Miller
   12. Marie-Gabrielle Ludwig

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Bridges et al., present a timely study on an adhesion G-protein coupled receptor known as GPR1116, which is an important regulator of lung function. The authors performed extensive mutagenesis and functional studies to characterize the structural determinants controlling GPR116 activity. With some additional controls, the conclusions of this study would have far-reaching implications for the development of pharmacological approaches aimed at modulating the activity of this important biological target involved in the maintenance of normal pulmonary functions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

    This article has 11 authors:

    1. Tamara Garrido-Gomez
    2. Nerea Castillo-Marco
    3. Mónica Clemente-Ciscar
    4. Teresa Cordero
    5. Irene Muñoz-Blat
    6. Alicia Amadoz
    7. Jorge Jimenez-Almazan
    8. Rogelio Monfort-Ortiz
    9. Reyes Climent
    10. Alfredo Perales-Marin
    11. Carlos Simon

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      Garrido-Gomez et al generate a unique dataset profiling the transcriptomes late-stage endometrium of women with prior pregnancies leading to severe preeclampsia (sPE) compared to that of non-preeclamptic pregnancies. Although the question of molecular drivers preeclampsia has been explored at the molecular level directly in the placenta, this study provides a unique view in the endometrium of women years after the pregnancy in question, which is consistent with the fact that a previous preeclamptic pregnancy is one of the best predictors for a subsequent preeclamptic pregnancy.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife