eLife

Latest preprint reviews

1. Fitness drivers of division of labor in vertebrates

   This article has 2 authors:

   1. Irene García-Ruiz
   2. Dustin Rubenstein

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study develops an individual-based model to investigate the evolution of division of labor in vertebrates, comparing the contributions of group augmentation and kin selection. The model incorporates several biologically relevant features, including age-dependent task switching and separate manipulation of relatedness and group-size benefits. However, the evidence remains incomplete to support the authors' central claim that group augmentation is the primary driver of vertebrate division of labor. Key modelling assumptions, such as limited opportunities for task synergy, the structure of helper and floater dynamics, and the relatively narrow parameter space explored, continue to restrict the potential for kin selection to produce division of labor, thereby limiting the generality of the conclusions.

   Reviewed by eLife

2. Five-Year Survival Outcomes for Breast Cancer Patients Across Continental Africa: A Contemporary Review of Literature with Meta Analysis

   This article has 9 authors:

   1. Augustina Badu-Peprah
   2. Ernest Kissi Kontor
   3. Adu-Gyamfi Benjamin
   4. Jessica Kumah
   5. Akosua Aya Essuman
   6. Bossoh Selorm
   7. Issahak Nurudeen
   8. Bismark Osei Owusu
   9. Nityanand Jain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable meta-analysis that highlights low and highly variable breast cancer survival rates across Africa, emphasizing the pressing need for public health in Africa. The evidence supporting the claims of the authors is solid, although a clarification of the crude 5-year survival rates would have strengthened the study. The work will be of interest to scientists working in the field of public health and breast cancer.

   Reviewed by eLife

3. Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization

   This article has 7 authors:

   1. Lin Chen
   2. Yanlun Gu
   3. Yuke Chen
   4. Wei Yu
   5. Ying Zhou
   6. Zhuona Rong
   7. Xiaocong Pang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a meta-analysis of two independent genome-wide association studies (GWAS) that investigate the role of plasma proteins as potential biomarkers for enhancing the early detection of prostate cancer (PCa). The results provide useful confirmatory data that support existing evidence currently published. The evidence is incomplete: the study does not provide a comprehensive synthesis of all currently published work, does not explore other clinical outcomes related to prostatic disease, and its findings have not been validated through an external cohort study. These shortcomings notwithstanding, the work may be of interest to researchers studying correlates and predictors of prostate cancer risk.

   Reviewed by eLife

4. MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets

   This article has 7 authors:

   1. Benjamin Gallean
   2. Tao Laurent
   3. Kilian Biasuz
   4. Ange Clement
   5. Noura Faraj
   6. Patrick Lemaire
   7. Emmanuel Faure

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work presents technical and conceptual advances with the release of MorphoNet 2.0, a versatile and accessible platform for 3D+T segmentation and analysis. The authors provide compelling evidence across diverse datasets, and the clarity of the manuscript together with the software's usability broadens its impact. Although the strength of some improvements is hard to fully gauge given sample complexity, the tool is a significant step forward that will likely impact many biological imaging fields.

   Reviewed by eLife

5. Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume

   This article has 3 authors:

   1. Risa Yamada
   2. Giovanni B Brandani
   3. Shoji Takada

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides a conceptual advance in our understanding of how membrane geometry modulates the balance between specific and non-specific molecular interactions, reversing multiphase morphologies in postsynaptic protein assemblies. Using a mesoscale simulation framework grounded in experimental binding affinities, the authors successfully recapitulate key experimental observations in both solution and membrane-associated systems, providing novel mechanistic insight into how spatial constraints regulate postsynaptic condensate organization. The conclusions are supported by solid strength of evidence and the findings are of broad significance for both computational and experimental biologists

   Reviewed by eLife

6. Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

   This article has 7 authors:

   1. Hiroki Toyoda
   2. Doyun Kim
   3. Byeong Geon Koh
   4. Tomomi Sano
   5. Takashi Kanematsu
   6. Seog Bae Oh
   7. Youngnam Kang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study explores a novel cellular mechanism underlying the degeneration of locus coeruleus neurons during chronic restraint stress. The evidence supporting the overexcitation of LC neurons after chronic stress is compelling. The topic is timely, the proposed mechanistic pathway is innovative, and the findings have translational relevance, particularly regarding therapeutic strategies targeting α2A-AR internalization in neurodegenerative diseases.

   Reviewed by eLife

7. Making plant tissue accessible for cryo-electron tomography

   This article has 19 authors:

   1. Matthias Pöge
   2. Marcel Dickmanns
   3. Peng Xu
   4. Meijing Li
   5. Oda H Schiøtz
   6. Christoph OJ Kaiser
   7. Jianfei Ma
   8. Anna Bieber
   9. Cristina Capitanio
   10. Johann Brenner
   11. Margot Riggi
   12. Sven Klumpe
   13. Manuel Miras
   14. Neda S Kazemein Jasemi
   15. Waltraud X Schulze
   16. Rüdiger Simon
   17. Wolf B Frommer
   18. Jürgen M Plitzko
   19. Wolfgang Baumeister

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Thick multicellular plant samples provide unique challenges when it comes to cryo-preservation, which has resulted in limited successful examples for structural studies using in situ cryo-electron tomography. To address this deficiency, this important study describes procedures for high-pressure-freezing, focused ion-beam milling, and cryo-electron tomography imaging of certain plant types. The results described in the paper provide solid evidence for the usefulness of the methods described, although some reservations remain about the applicability of the methods to a wider range of plant cell types.

   Reviewed by eLife

8. Correlation detection as a stimulus computable account for audiovisual perception, causal inference, and saliency maps in mammals

   This article has 1 author:

   1. Cesare V Parise

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study evaluates a model for multisensory correlation detection, focusing on the detection of correlated transients in visual and auditory stimuli. Overall, the experimental design is sound and the evidence is compelling. The synergy between the experimental and theoretical aspects of the article is strong, and the work will be of interest to both neuroscientists and psychologists working in the domain of sensory processing and perception

   Reviewed by eLife

9. Cellular and synaptic organization of the Octopus vertical lobe

   This article has 5 authors:

   1. Flavie Bidel
   2. Yaron Meirovitch
   3. Fuming Yang
   4. Jeff William Lichtman
   5. Binyamin Hochner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study of the inhibitory complex amacrines (CAM) in the vertical lobe of Octopus vulgaris delivers a solid standard for the structural characterization of an anatomical region likely to be key for memory processing in this unconventional but complex organism, as well as a helpful classification of CAM subtypes. This work will be of broad relevance to the fields of memory and evolutionary neuroscience.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.48550/arxiv.2307.12956v3