Latest preprint reviews

  1. Impaired Adaptive Learning in Chronic Pain Contributes to Apathy

    This article has 7 authors:
    1. Xinyuan Yan
    2. Crina M Peterson
    3. Lisa M Schmidt
    4. Seth Koenig
    5. Donald R Nixdorf
    6. Alexander Herman
    7. David P Darrow
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides a useful application of computational modelling to examine how people with chronic pain learn under uncertainty, contributing to efforts to link pain with motivational processes. However, the evidence supporting the main claims is incomplete, as the modelling differences are not reflected in observable behaviour or pain measures, and the interpretation extends beyond what the data can substantiate. The conclusions would benefit from a clearer explanation of the behavioural differences that underlie the computational findings.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Comparative developmental transcriptomics of Drosophila mushroom body neurons highlights the mevalonate pathway as a regulator of axon growth

    This article has 5 authors:
    1. Lora Fahdan
    2. Hagar Meltzer
    3. Noa Wigoda
    4. Ron Rotkopf
    5. Oren Schuldiner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work contributes a transcriptional dataset that identifies potential genes involved in axon initial growth and axon regrowth, followed by a characterization of axon phenotypes after knockdown of a subset of these genes. Focused experiments on a single gene, Pmvk, highlight the potential role of the mevalonate pathway in axon regrowth. The methods are convincing, though partially incomplete. The data establish a basis for further studies on axonal development and will be of interest to both developmental neurobiologists and those seeking to develop molecular tools to target, monitor, and manipulate axon morphology and function.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Neural Traces of Forgotten Memories Persist in Humans and are Behaviorally Relevant

    This article has 6 authors:
    1. Tom Willems
    2. Konstantinos Zervas
    3. Luzius Brogli
    4. Finn Rabe
    5. Andrea Federspiel
    6. Katharina Henke
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a potentially important paper attempting to identify neutral correlates of memory engram expression in humans, and how they change during forgetting. The questions posed are clear and novel. The methods employed, namely behavioral analysis, high-resolution functional magnetic resonance imaging, and representational similarity analysis, are advanced, integrative, and appropriate. The experiments are well designed and combine analysis of recollection and familiarity of object/face associations. However, substantial questions remain as to the validity of the incomplete statistical analyses applied to the imaging data, as well as the parsing of and interpretation of the behavioral data.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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