Latest preprint reviews

1. Diversity and functional specialization of oyster immune cells uncovered by integrative single cell level investigations

   This article has 9 authors:

   1. Sébastien de La Forest Divonne
   2. Juliette Pouzadoux
   3. Océane Romatif
   4. Caroline Montagnani
   5. Guillaume Mitta
   6. Delphine Destoumieux-Garzon
   7. Benjamin Gourbal
   8. Guillaume M Charrière
   9. Emmanuel Vignal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript offers an exploration of the immune cells in the oyster Crassostrea gigas, by correlating distinct hemocyte morphotypes with specific single-cell transcriptional profiles. The evidence supporting the conclusion is convincing, deriving from the comprehensive dataset that not only captures unicellular diversity but also associates these cells with distinct immune roles, making it an important resource for the broader research community. There are some concerns on the data presentation that leave some questions.

   Reviewed by eLife

2. TRPV3 channel activity helps cortical neurons stay active during fever

   This article has 4 authors:

   1. Yiming Shen
   2. Richárd Fiáth
   3. István Ulbert
   4. Michelle W Antoine

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study of the physiological mechanisms promoting network activity during fever in the mouse neocortex. Most of the supporting evidence is solid, however, there is incomplete support for the conclusion that the E/I balance is unchanged with temperature.

   Reviewed by eLife

3. The promise and peril of comparing fluorescence lifetime in biology revealed by simulations

   This article has 3 authors:

   1. Pingchuan Ma
   2. Scott Sternson
   3. Yao Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes a computational tool termed FliSimBA (Fluorescence Lifetime Simulation for Biological Applications), which uses simulations to rigorously assess experimental limitations in fluorescence lifetime imaging microscopy (FLIM), including diverse noise factors, hardware effects, and sensor expression levels. The evidence from simulation and experimental measurements supporting the usefulness of FlimSimBA is solid. The authors may improve the application of the tool to a wide range of biological samples by providing the simulation package, currently in MATLB, in other common languages such as Python, and having better descriptions of the fitting algorithm and model assumptions. The work will interest scientists who wish to perform quantitative FLIM imaging for cells and tissues.

   Reviewed by eLife

4. Realistic mossy fiber input patterns to unipolar brush cells evoke a continuum of temporal responses comprised of components mediated by different glutamate receptors

   This article has 2 authors:

   1. Vincent Huson
   2. Wade G Regehr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Huson & Regehr characterize the spiking responses of UBCs to various patterns of synaptic stimulation and dissect the contributions of relevant glutamate receptors to their transformations. This study presents valuable findings describing how trains of mossy fiber stimulation control cerebellar unipolar brush cell discharges. The evidence that UBCs transform signals in diverse ways depending on their complement of AMPA, mGluR1, and mGluR2 receptors is solid.

   Reviewed by eLife

5. Mistargeted retinal axons form synaptically segregated subcircuits in the visual thalamus of albino mice

   This article has 7 authors:

   1. Sean McCracken
   2. Liam McCoy
   3. Ziyi Hu
   4. Julie Hodges
   5. Katia Valkova
   6. Philip R Williams
   7. Josh Morgan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important morphological observations related to the potential roles of Hebbian plasticity in establishing brain connectivity, by examining synapses formed by functionally distinct groups of retinal ganglion cell (RGC) axons in albino mouse dorsolateral geniculate nucleus (dLGN). Here, inappropriately projecting contralateral RGCs undergo developmental rewiring alongside ipsilateral RGCs, such that Hebbian theory would predict them to have separate synaptic targets. The authors provide compelling support for some presence of Hebbian rewiring, using combined confocal imaging and serial electron microscopy (EM) reconstructions to show that contralateral RGCs form completely segregated synaptic inputs onto islands of dLGN thalamocortical neurons, as well as somewhat segregated synaptic input onto local inhibitory interneurons. These findings will be of interest to researchers studying synaptic connectivity and plasticity during development.

   Reviewed by eLife

6. Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

   This article has 9 authors:

   1. Baikui Wang
   2. Xianqi Peng
   3. Xiao Zhou
   4. Abubakar Siddique
   5. Jiayun Yao
   6. Haiqi Zhang
   7. Weifen Li
   8. Yan Li
   9. Min Yue

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this manuscript, Wang et al describe the identification, and provide initial mechanistic characterization, of a potent probiotic strain with activity against Salmonella enterica infection. The evidence provided is compelling, with multiple and varied methodologies used to support the claims made by the authors. The findings reported are valuable to the probiotic and enteric infection subfields.

   Reviewed by eLife

7. Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity

   This article has 10 authors:

   1. William R Thomas
   2. Troy Richter
   3. Erin T O’Neil
   4. Cecilia Baldoni
   5. Angelique P Corthals
   6. Dominik von Elverfeldt
   7. John Nieland
   8. Dina KN Dechmann
   9. Richard G Hunter
   10. Liliana M Dávalos

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings related to seasonal brain size plasticity in the Eurasian common shrew (Sorex araneus), which is an excellent model system for these studies. The evidence supporting the authors' claims is convincing. However, the authors should be careful when applying the term adaptive to the gene expression changes they observe; it would be challenging to demonstrate the differential fitness effects of these gene expression changes. The work will be of interest to biologists working on neuroscience, plasticity, and evolution.

   Reviewed by eLife

8. Confidence over competence: Real-time integration of social information in human continuous perceptual decision-making

   This article has 7 authors:

   1. Felix Schneider
   2. Antonino Calapai
   3. Roger Mundry
   4. Raymundo Báez-Mendoza
   5. Alexander Gail
   6. Igor Kagan
   7. Stefan Treue

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study used a novel continuous dot motion decision-making task to measure participants' perception and uncertainty/confidence in a social context. The social element is that participants can see another player's responses as well as their own. The study is a useful contribution to social decision-making primarily by introducing a new task and offering solid evidence on how participants are impacted by others' decisions during continuous perceptual choices. The manuscript could be improved through streamlining, more consistent use of terms such as "dyadic" and clarification about the differences between primary uncertainty and metacognitive confidence.

   Reviewed by eLife

9. Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

   This article has 12 authors:

   1. Arkajyoti Bhattacharya
   2. Thijs S Stutvoet
   3. Mirela Perla
   4. Stefan Loipfinger
   5. Mathilde Jalving
   6. Anna KL Reyners
   7. Paola D Vermeer
   8. Ronny Drapkin
   9. Marco de Bruyn
   10. Elisabeth GE de Vries
   11. Steven de Jong
   12. Rudolf SN Fehrmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study uses consensus-independent component analysis to highlight transcriptional components (TC) in high-grade serous ovarian cancers (HGSOC). The study presents a convincing preliminary finding by identifying a TC linked to synaptic signaling that is associated with shorter overall survival in HGSOC patients, highlighting the potential role of neuronal interactions in the tumor microenvironment. This finding is corroborated by comparing spatially resolved transcriptomics in a small-scale study; a weakness is in being descriptive, non-mechanistic, and requiring experimental validation.

   Reviewed by eLife

10. Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance

    This article has 4 authors:

    1. Xue Chen
    2. Deng Pan
    3. Jia-Jia Liu
    4. Yanrui Yang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic synapses by acting as a component of the inhibitory postsynaptic density. Although the study employs a variety of approaches to address this question, the current analysis is incomplete and requires further experiments to substantiate the claims fully. The findings are likely to interest a broad audience of scientists focusing on inhibitory synaptic transmission, the excitation-inhibition balance, and its disruption in disorders such as epilepsy.

    Reviewed by eLife