eLife

Latest preprint reviews

1. A Titin Missense Variant Causes Atrial Fibrillation

   This article has 14 authors:

   1. Mahmud Arif Pavel
   2. Hanna Chen
   3. Michael Hill
   4. Arvind Sridhar
   5. Miles Barney
   6. Jaime DeSantiago
   7. Asia Owais
   8. Shashank Sandu
   9. Faisal A Darbar
   10. Aylin Ornelas-Loredo
   11. Bahaa Al-Azzam
   12. Brandon Chalazan
   13. Jalees Rehman
   14. Dawood Darbar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents valuable findings regarding the incidence and clinical impact of a mutation in a cardiac muscle protein and its association with the development of atrial fibrillation. The authors provide some convincing evidence of electrophysiological disturbances in cells with this mutation which would be of interest to cellular electrophysiologists. However, evidence supporting the conclusion that this mutation causes atrial fibrillation would benefit from more rigorous electrophysiologic approaches.

   Reviewed by eLife

2. Heat Stress Induced Bacterial Tolerance against Phage Facilitates the Evolution of Resistance

   This article has 7 authors:

   1. Fan Zhang
   2. Hao-Ze Chen
   3. Bo Zheng
   4. Liang Huang
   5. Ye Xiang
   6. Jing-Ren Zhang
   7. Liu Jiafeng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study analyzes the effect of heat treatment on phage-bacterial interactions and convincingly shows that prior heat exposure alters the bacterial cell envelope, enhancing persistence and bacterial survival when exposed to lytic phages. The study will interest researchers working on antibiotic resistance, tolerance, and phage therapy.

   Reviewed by eLife

3. The capsule and genetic background, rather than specific loci, strongly influence pneumococcal growth kinetics

   This article has 11 authors:

   1. Chrispin Chaguza
   2. Daan W Arends
   3. Stephanie W Lo
   4. Indri Hapsari Putri
   5. Anna York
   6. John A Lees
   7. Anne L Wyllie
   8. Daniel M Weinberger
   9. Stephen D Bentley
   10. Marien I de Jonge
   11. Amelieke JH Cremers

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that examines the impact of Streptococcus pneumoniae genetics on its in vitro growth kinetics, aiming to identify potential targets for vaccines and therapeutics. The study identified significant variations in growth characteristics among capsular serotypes and lineages, linked to phylogeny and high heritability, but genome-wide association studies did not reveal specific genomic loci associated with growth features independent of the genetic background. The evidence supporting these findings is solid.

   Reviewed by eLife

4. Dynamic modulation of social gaze by sex and familiarity in marmoset dyads

   This article has 5 authors:

   1. Feng Xing
   2. Alec G Sheffield
   3. Monika P Jadi
   4. Steve WC Chang
   5. Anirvan S Nandy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study establishes the methodology (machine vision and gaze pose estimation) and behavioral apparatus for examining social interactions between pairs of marmoset monkeys. Their results enable unrestrained social interactions under more rigorous conditions with detailed quantification of position and gaze. It has been difficult to study social interactions using artificial stimuli, as opposed to genuine interactions between unrestrained animals. This study makes an important contribution to studying social neuroscience within a laboratory setting; the approach is novel and well-executed, backed by convincing evidence.

   Reviewed by eLife

5. The relationship between cognitive abilities and mental health as represented by cognitive abilities at the neural and genetic levels of analysis

   This article has 3 authors:

   1. Yue Wang
   2. Richard Anney
   3. Narun Pat

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the relationship between cognition and mental health and investigates how brain, genetics, and environmental measures mediate that relationship. The methods and results are compelling and well-executed. Overall, this study will be of interest in the field of population neuroscience and in studies of mental health.

   Reviewed by eLife

6. A gradual transition toward categorical representations along the visual hierarchy during working memory, but not perception

   This article has 4 authors:

   1. Chaipat Chunharas
   2. Michael J Wolff
   3. Meike D Hettwer
   4. Rosanne L Rademaker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examined orientation representations along the visual hierarchy during perception and working memory. The authors provide results suggesting that during working memory there is a gradient where representations are more categorical in nature later in the visual hierarchy. The evidence presented is solid, most notably a match between behavioral data, though minor weakness can be attributed to the tasks and behaviors not being designed to address this question. The findings should be of interest to a relatively broad audience, namely those interested in the relationship between sensory coding and memory.

   Reviewed by eLife

7. Synaptic Connectivity of Sensorimotor Circuits for Vocal Imitation in the Songbird

   This article has 6 authors:

   1. Massimo Trusel
   2. Ziran Zhao
   3. Danyal Alam
   4. Ethan Marks
   5. Maaya Ikeda
   6. Todd F Roberts

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The songbird vocal motor nucleus HVC contains cells that project to the basal ganglia, the auditory system, or downstream vocal motor structures. In this fundamental study, the authors conduct optogenetic circuit mapping to clarify how four distinct inputs to HVC act on these distinct HVC cell types. They provide compelling evidence that all long-range projections engage inhibitory circuits in HVC and can also exhibit cell-type specific preferences in monosynaptic input strength. Understanding the HVC microcircuit at this microcircuit level is critical for informing models of song learning and production.

   Reviewed by eLife

8. Distancing alters the controllability of emotional states by affecting both intrinsic stability and extrinsic sensitivity

   This article has 2 authors:

   1. Jolanda Malamud
   2. Quentin JM Huys

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important manuscript proposes a dual behavioral/computational approach to assess emotional regulation in humans. The authors present solid evidence for the idea that emotional distancing (as routinely used in clinical interventions for e.g. mood and anxiety disorders) enhances emotional control.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2404.17495v2

10. Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

    This article has 8 authors:

    1. Sunayana Sarkar
    2. Harsha Sharma
    3. SK Yasir Hosen
    4. Jayashree S Ladke
    5. Deepa Balasubramanian
    6. Sreejith Raran-Kurussi
    7. Rashna Bhandari
    8. Manish Jaiswal

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Studying the biological roles of polyphosphates in metazoans has been a longstanding challenge to the field given that the polyP synthase has yet to be discovered in metazoans. This important study capitalizes on the sophisticated genetics available in the Drosophila system and uses a combination of methodologies to start to tease apart how polyphosphate participates in Drosophila development and in the clotting of Drosophila hemolymph. The data validating the tools are solid and well-documented and they will open up a field of research into the functional roles of polyP in a metazoan model.

    Reviewed by eLife