eLife

Latest preprint reviews

1. Skull Bone Marrow Drainage and Its Associations with Inflammation, Sleep Quality, and Cognitive Performance

   This article has 10 authors:

   1. Ying Zhou
   2. Haidi Jin
   3. Xiao Zhu
   4. Yifei Li
   5. Ziyu Zhou
   6. Xin Huang
   7. Huihong Ke
   8. Mengmeng Fang
   9. Jianzhong Sun
   10. Min Lou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a well-executed intrathecal MRI tracer study that provides valuable early in vivo evidence for CSF drainage into human skull bone marrow and explores clinically relevant associations using robust imaging methodology and regional analyses. However, the evidence supporting the interpretation of early (4 h) tracer signal as impaired clearance is incomplete, and appears difficult to reconcile with established CSF tracer kinetics. They also note that the reported links to sleep and cognitive performance are weakened by reliance on subjective, retrospective questionnaires rather than objective physiological measurements.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2025.11.03.686355

3. AutoMorphoTrack: A modular framework for quantitative analysis of organelle morphology, motility, and interactions at single-cell resolution

   This article has 3 authors:

   1. Armin Bayati
   2. Jackson G Schumacher
   3. Xiqun Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work describes a useful computational tool for automated morphometry of dynamic organelles from microscope images. However, the supporting evidence and novelty of the manuscript as presented are incomplete and could be improved. The work will be of interest to microscopists and bioimage analysts who are non-experts but wish to improve quantitative analysis of cellular structures.

   Reviewed by eLife

4. Complex environmental cycles reveal evolution of circadian activity waveform and thermosensitive timeless splicing

   This article has 2 authors:

   1. Pragya Niraj Sharma
   2. Vasu Sheeba

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines how mismatched light and temperature cycles shape Drosophila locomotor timing and temperature-dependent timeless splicing, and leverages long-term early/late selection lines to probe evolutionary plasticity. The strength of evidence is incomplete at present, mainly because startle/masking under step cues could confound the behavioural readouts, and tim's involvement remains correlative. The authors should address masking in the behaviour analyses and provide causal support for tim's role.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2025.11.11.687834

6. We couldn't get details of this article at this time:
   10.1101/2025.10.31.685719

7. Decoding state specific connectivity during speech production and perception

   This article has 7 authors:

   1. Yasamin Esmaeili
   2. Amirhossein Khalilian-Gourtani
   3. Orrin Devinsky
   4. Werner K Doyle
   5. Patricia Dugan
   6. Daniel Friedman
   7. Adeen Flinker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work represents a valuable finding of how single-trial functional connectivity may be used to infer different cognitive states involved in speech perception and production. Although the data and analyses are overall convincing, the theoretical advance and novelty of the finding are less clear. With a clearer idea of the functional significance of the connectivity data, the paper would be of interest to those interested in brain networks and communication.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.08.26.672247

9. E3 Ubiquitin Ligase Highwire/Phr1 Phase Separation Mediates Endocytic Control of JNK Signaling in Drosophila Neurons

   This article has 7 authors:

   1. Srikanth Pippadpally
   2. Anjali Bisht
   3. Saumitra Dey Choudhury
   4. Manish Kumar Dwivedi
   5. Zeeshan Mushtaq
   6. Suneel Reddy-Alla
   7. Vimlesh Kumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable findings on how the activity of the E3 ubiquitin ligase Highwire (Hiw/Phr1) is regulated and its impact on synaptic growth. The authors propose that impaired endocytosis leads to condensation of Hiw, resulting in increased synaptic growth. They also integrate such a mechanism within the known JNK (c-JUN N-terminal Kinase) and BMP (Bone Morphogenetic Protein) signalling pathways involved in synapse regulation. While the work raises an interesting mechanistic framework, several aspects of the experimental design and methodology are incomplete, and key conclusions, particularly those regarding the liquid-liquid phase separation of the E3 ubiquitin ligase, are not fully supported by the presented data.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.64898/2025.11.30.691401