eLife

Latest preprint reviews

1. The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

   This article has 15 authors:

   1. Minato Hirano
   2. Gaddiel Galarza-Muñoz
   3. Chloe Nagasawa
   4. Geraldine Schott
   5. Liuyang Wang
   6. Alejandro L Antonia
   7. Vaibhav Jain
   8. Xiaoying Yu
   9. Steven G Widen
   10. Farren BS Briggs
   11. Simon G Gregory
   12. Dennis C Ko
   13. William S Fagg
   14. Shelton Bradrick
   15. Mariano A Garcia-Blanco

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this study, DDX39B, a factor with known functions in mRNA splicing and nuclear export, is shown to regulate Foxp3, a lineage marker for T-regulatory cells in the immune system. The interactions are positioned in the context of multiple sclerosis and autoimmune inflammatory condition. The work would be of interest to immunologists and those studying RNA-mediated regulation and cellular signaling.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

2. Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

   This article has 11 authors:

   1. Timothy J Mead
   2. Daniel R Martin
   3. Lauren W Wang
   4. Stuart A Cain
   5. Cagri Gulec
   6. Elisabeth Cahill
   7. Joseph Mauch
   8. Dieter Reinhardt
   9. Cecilia Lo
   10. Clair Baldock
   11. Suneel S Apte

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The study by Mead and colleagues proves that the in vivo genetic interactions between Adamts 6 and fibrillin 2 is critical for normal endochondral bone development. In particular, the authors show that global loss of ADAMTS6 causes a severe chondrodysplasia that is significantly worsened by concomitant loss of ADAMTS10 and, conversely, almost fully prevented by haploinsufficiency for fibrillin 2, a substrate of ADAMTS6. The paper expands and deepens our current undertstanding of proteases and their substrates in endochondral bone development.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

3. Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

   This article has 3 authors:

   1. Ann Rancourt
   2. Sachiko Sato
   3. Masahiko S Satoh

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper examines the role of p53 in cell division by using a combination of live-cell imaging, cell tracking, and simulations. Overall, the results are extensively and transparently documented, and are of interest to cell biologists studying cell division, cell death, and p53.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

4. Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains

   This article has 6 authors:

   1. Luna Gao
   2. Jian Zhao
   3. Evan Ardiel
   4. Qi Hall
   5. Stephen Nurrish
   6. Joshua M Kaplan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors use C. elegans to explore the relationship between shank (an Autism-associated gene orthologue), CaV1 (Ca) channels, and BK (slo) calcium-dependent K channels in controlling muscle excitability. The data annotate a novel activity of Shank as an organizer of ion channel domains with potential relevance to human disease.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

5. Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

   This article has 7 authors:

   1. Alex N Nguyen Ba
   2. Katherine R Lawrence
   3. Artur Rego-Costa
   4. Shreyas Gopalakrishnan
   5. Daniel Temko
   6. Franziska Michor
   7. Michael M Desai

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Overall, this is an impressive and interesting piece of work that not only expands the identification of small-effect QTL, but also reveals epistatic interactions at an unprecedented scale. Their approach takes advantage of DNA barcodes to increase the scale of genetic mapping studies in yeast by an order of magnitude over previous studies, yielding a more complete and precise view of the QTL landscape and confirming widespread epistatic interactions between the different QTL.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. A cellular and molecular atlas reveals the basis of chytrid development

   This article has 6 authors:

   1. Davis Laundon
   2. Nathan Chrismas
   3. Kimberley Bird
   4. Seth Thomas
   5. Thomas Mock
   6. Michael Cunliffe

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work provides transcriptional profiling and structural insight into chytrid development and will very likely stimulate further work on this model.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.

   Reviewed by eLife

7. A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

   This article has 9 authors:

   1. David J Turner
   2. Alexander Saveliev
   3. Fiamma Salerno
   4. Louise S Matheson
   5. Michael Screen
   6. Hannah Lawson
   7. David Wotherspoon
   8. Kamil R Kranc
   9. Martin Turner

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper utilizes an elegant Crispr-Cas9 screen to identify RNA binding proteins that may regulate B cell differentiation. With some additional work to verify that the identified proteins are important in vivo, the paper will be of interest to a broad audience of immunologists studying the signals regulating B cell differentiation during an immune response.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice

   This article has 26 authors:

   1. Alex Moshensky
   2. Cameron S Brand
   3. Hasan Alhaddad
   4. John Shin
   5. Jorge A Masso-Silva
   6. Ira Advani
   7. Deepti Gunge
   8. Aditi Sharma
   9. Sagar Mehta
   10. Arya Jahan
   11. Sedtavut Nilaad
   12. Jarod Olay
   13. Wanjun Gu
   14. Tatum Simonson
   15. Daniyah Almarghalani
   16. Josephine Pham
   17. Samantha Perera
   18. Kenneth Park
   19. Rita Al-Kolla
   20. Hoyoung Moon
   21. Soumita Das
   22. Min Kwang Byun
   23. Zahoor Shah
   24. Youssef Sari
   25. Joan Heller Brown
   26. Laura E Crotty Alexander

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a potentially important paper that aimed to investigate the effects of vaping on multiple organs. The authors show multi-organ inflammatory responses of JUUL exposure in mice. While the rationale of the current study if of high interest and timely, the manuscript in its current form remains largely descriptive and some of the conclusions are not clearly supported by the data. A major limitation is the lack of investigation of (causal) pathophysiological consequences/general organ outcomes that might be driven by the reposted inflammatory response.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. The control and training of single motor units in isometric tasks are constrained by a common input signal

   This article has 7 authors:

   1. Mario Bräcklein
   2. Deren Yusuf Barsakcioglu
   3. Jaime Ibáñez
   4. Jonathan Eden
   5. Etienne Burdet
   6. Carsten Mehring
   7. Dario Farina

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Bräcklein et al. provide compelling data suggesting that humans cannot learn to independently control multiple motor units innervating a single lower-limb muscle. These results suggest that common drive to motor units, along with the classical size-recruitment order, will impose strong constraints on the use of high-resolution muscle recordings for controlling brain-computer interfaces. Additional analysis related to task construction and motor unit identification/sorting is required to justify this claim.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. Human visual gamma for color stimuli

    This article has 5 authors:

    1. Benjamin J Stauch
    2. Alina Peter
    3. Isabelle Ehrlich
    4. Zora Nolte
    5. Pascal Fries

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This is an interesting article studying human color perception using MEG. The specific aim was to study differences in color perception related to different S-, M-, and L-cone excitation levels and especially whether red color is perceived differentially to other colors. The study addresses an interesting question. The methods are strong. The data broadly support the conclusion, although some additional analyses would offer further support.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife