eLife

Latest preprint reviews

1. Unleashing a novel function of Endonuclease G in mitochondrial genome instability

   This article has 7 authors:

   1. Sumedha Dahal
   2. Humaira Siddiqua
   3. Shivangi Sharma
   4. Ravi K Babu
   5. Diksha Rathore
   6. Sheetal Sharma
   7. Sathees C Raghavan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of interest for researchers in the field of mitochondrial genome stability and mitochondrial genetic diseases. The authors show that endonuclease G preferentially binds to mitochondrial genome regions which have a potential for forming G4 tetraplexes, inducing DNA breaks that may lead to a common 9 bp deletion in the mitochondrial genome by microhomology-mediated endjoining.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. Lung evolution in vertebrates and the water-to-land transition

   This article has 13 authors:

   1. Camila Cupello
   2. Tatsuya Hirasawa
   3. Norifumi Tatsumi
   4. Yoshitaka Yabumoto
   5. Pierre Gueriau
   6. Sumio Isogai
   7. Ryoko Matsumoto
   8. Toshiro Saruwatari
   9. Andrew King
   10. Masato Hoshino
   11. Kentaro Uesugi
   12. Masataka Okabe
   13. Paulo M Brito

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study used valuable materials from five osteichthyan vertebrate species and investigated their lung morphology in them. The comparison of the observations suggest an origin of the lung as an unpaired organ, with the present-day paired forms in amniotes being a result of secondary modification. The sound morphological comparison presented provides valuable insight into the evolution of the lung. The work will be of interest to colleagues studying vertebrate evolution.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

3. Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

   This article has 12 authors:

   1. Stefano G Giulieri
   2. Romain Guérillot
   3. Sebastian Duchene
   4. Abderrahman Hachani
   5. Diane Daniel
   6. Torsten Seemann
   7. Joshua S Davis
   8. Steven YC Tong
   9. Bernadette C Young
   10. Daniel J Wilson
   11. Timothy P Stinear
   12. Benjamin P Howden

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study offers a comprehensive examination of Staphylococcus aureus evolution during infection. This manuscript will be of broad interest to readers in the field of microbiology and infectious disease. It provides a useful analysis of a comprehensive set of genetic signatures of bacterial adaptation. A combination of multiple layers of genome annotation and point mutation variant detection compellingly supports the correlation of infection outcomes with adaptation signatures in S. aureus.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

4. The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

   This article has 15 authors:

   1. Robin F Dard
   2. Erwan Leprince
   3. Julien Denis
   4. Shrisha Rao Balappa
   5. Dmitrii Suchkov
   6. Richard Boyce
   7. Catherine Lopez
   8. Marie Giorgi-Kurz
   9. Tom Szwagier
   10. Théo Dumont
   11. Hervé Rouault
   12. Marat Minlebaev
   13. Agnès Baude
   14. Rosa Cossart
   15. Michel A Picardo

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study investigates hippocampal dynamics over the course of early postnatal development with respect to spontaneous movements. Pioneering in vivo imaging in the hippocampus of neonatal mice, the authors find evidence for an abrupt developmental transition in this neural activity at the end of the first postnatal week in rodents and contribute to the understanding of how cognitive functions could emerge from the immature brain.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Contribution of behavioural variability to representational drift

   This article has 2 authors:

   1. Sadra Sadeh
   2. Claudia Clopath

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work builds on rapidly accumulating evidence for the importance of measuring and accounting for behavior in neural data, and will be of interest to a broad neuroscience audience. Analyses of Allen Brain Atlas datasets show that sensory representations change and match up reliably with behavioral state. The manuscript's main conclusions are supported by the data and analyses and the work raises important questions about previous accounts of the sources of representational drift in sensory areas of the brain.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells

   This article has 23 authors:

   1. Huachao Huang
   2. Yinshan Fang
   3. Ming Jiang
   4. Yihan Zhang
   5. Jana Biermann
   6. Johannes C Melms
   7. Jennifer A Danielsson
   8. Ying Yang
   9. Li Qiang
   10. Jia Liu
   11. Yiwu Zhou
   12. Manli Wang
   13. Zhihong Hu
   14. Timothy C Wang
   15. Anjali Saqi
   16. Jie Sun
   17. Ichiro Matsumoto
   18. Wellington V Cardoso
   19. Charles W Emala
   20. Jian Zhu
   21. Benjamin Izar
   22. Hongmei Mou
   23. Jianwen Que

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study addresses an interesting question in lung regeneration following viral injury. The authors describe the ectopic differentiation of tuft cells that were derived from lineage-tagged p63+ cells post influenza virus infection. These tuft cells do not appear to proliferate or give rise to other lineages. Importantly, they demonstrate that depletion of tuft cells caused by genetic deletion of Pou2f3 in p63+ cells has no effect on the expansion or resolution of Krt5+ pods after infection, implying that tuft cells play no functional role in this process.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife, ScreenIT

7. Nanoscale resolution of microbial fiber degradation in action

   This article has 7 authors:

   1. Meltem Tatli
   2. Sarah Moraïs
   3. Omar E Tovar-Herrera
   4. Yannick J Bomble
   5. Edward A Bayer
   6. Ohad Medalia
   7. Itzhak Mizrahi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The premise behind this manuscript is timely and of interest to a broad scientific community working in the field of microbial recycling of cellulosic biomass. It provides a useful link between the occurrence and molecular aspects of the bacterial 'machinery' named cellulosome, and physiological traits of the same bacteria when grown on micro-crystalline cellulose. The key claims of the manuscript are well supported by the data, and the approaches used are thoughtful and rigorous.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

8. A dual-target herbicidal inhibitor of lysine biosynthesis

   This article has 6 authors:

   1. Emily RR Mackie
   2. Andrew S Barrow
   3. Rebecca M Christoff
   4. Belinda M Abbott
   5. Anthony R Gendall
   6. Tatiana P Soares da Costa

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This excellent paper presents the highly interesting finding of a compound that inhibits two targets in lysine synthesis. Further, the mechanisms for the first enzyme is allosteric inhibition, while for the second enzyme the compound is a competitive inhibitor. The authors nicely explain why this is of significant interest for herbicide resistance management with a new compound. The authors convincingly demonstrate that the compound is not a pro-herbicide, and instead that the higher in vivo relative to in vitro activity is due to the additional inhibition of the second step in lysine synthesis. The work is of interest to those studying enzymology, herbicide action and evolution of herbicide resistance.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

9. Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

   This article has 5 authors:

   1. Lan Wang
   2. Hannah Toutkoushian
   3. Vladislav Belyy
   4. Claire Y Kokontis
   5. Peter Walter

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work extends our understanding of the ATAD1 family of AAA proteins responsible for extracting tail-anchored (TA) proteins mistargeted to the mitochondria. The conclusions of this work are largely consistent to prior structural studies from the same group, but provide clarifications of specific details that will be of interest to those working on these important proteins.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. GENESPACE tracks regions of interest and gene copy number variation across multiple genomes

    This article has 9 authors:

    1. John T Lovell
    2. Avinash Sreedasyam
    3. M Eric Schranz
    4. Melissa Wilson
    5. Joseph W Carlson
    6. Alex Harkess
    7. David Emms
    8. David M Goodstein
    9. Jeremy Schmutz

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This manuscript describing GENESPACE was found to be of high interest for the genomics community across many different fields. GENESPACE is a new and straightforward computational tool to include synteny information in the calculation of genome-wide sets of orthologs. This is very timely as more and more chromosome-scale assembled genomes are becoming available.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife