eLife

Latest preprint reviews

1. Prenatal development of neonatal vocalizations

   This article has 6 authors:

   1. Darshana Z Narayanan
   2. Daniel Y Takahashi
   3. Lauren M Kelly
   4. Sabina I Hlavaty
   5. Junzhou Huang
   6. Asif A Ghazanfar

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of great interest to the field of developmental neuroscience and social communication. The authors identified prenatal sensorimotor vocal precursors by detecting rhythmic orofacial movements related to vocalizations. These findings will provide new insights into the development of vocal behavior in primates. The data acquired by a highly quantitative approach support the major claims of the paper.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

2. Two enhancer binding proteins activate σ54-dependent transcription of a quorum regulatory RNA in a bacterial symbiont

   This article has 9 authors:

   1. Ericka D Surrett
   2. Kirsten R Guckes
   3. Shyan Cousins
   4. Terry B Ruskoski
   5. Andrew G Cecere
   6. Denise A Ludvik
   7. C Denise Okafor
   8. Mark J Mandel
   9. Tim I Miyashiro

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript has the potential to transform the field of sensory transduction and gene regulation in the Vibrio genus by uncovering a previously undescribed enhancer binding protein and its role in the regulation of quorum sensing and physiology in the Vibrio - squid symbiosis. However, in its present form, several experiments are required to support the claims of the manuscript.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling

   This article has 14 authors:

   1. Rafaela M Guimarães
   2. Conceição E Aníbal-Silva
   3. Marcela Davoli-Ferreira
   4. Francisco Isaac F Gomes
   5. Atlante Mendes
   6. Maria CM Cavallini
   7. Miriam M Fonseca
   8. Samara Damasceno
   9. Larissa P Andrade
   10. Marco Colonna
   11. Cyril Rivat
   12. Fernando Q Cunha
   13. José C Alves-Filho
   14. Thiago M Cunha

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Guimaraes et al address the origin of the macrophage increase in sensory ganglia after peripheral nerve injury. The authors show that there is no major influx by blood-derived monocytes into ganglia after injury and that resident macrophages proliferate, which is dependent on CX3CR1 signaling. Overall the work is clear and sound and should be of interest to immunologists and neurobiologists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

4. ABCA1 causes an asymmetric cholesterol distribution to regulate intracellular cholesterol homeostasis

   This article has 2 authors:

   1. Fumihiko Ogasawara
   2. Kazumitsu Ueda

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The mechanisms that control cholesterol movement from the plasma membrane (PM) to the endoplasmic reticulum (ER) remain poorly understood. Here, Ogasawara and Ueda propose an intriguing mechanism whereby ABCA1, a membrane protein, moves cholesterol from the inner to the outer leaflet of the PM to keep the cholesterol away from intracellular Aster proteins that move cholesterol to the ER. When cholesterol builds up beyond a threshold, it accumulates on the inner leaflet and is transported to ER by Asters. If strengthened by the analysis of the endogenous ABCA1 and more physiological cholesterol manipulation, this work will be of significant interest to scientists studying lipid metabolism and transport.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

5. The interpretation of computational model parameters depends on the context

   This article has 6 authors:

   1. Maria Katharina Eckstein
   2. Sarah L Master
   3. Liyu Xia
   4. Ronald E Dahl
   5. Linda Wilbrecht
   6. Anne GE Collins

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Eckstein and colleagues take a within-participant approach to answer two critical questions in the field of human reinforcement learning: to what extent do estimated computational model parameters generalize across different tasks and can their meaning be interpreted in the same way in different task contexts? The authors find that inferred parameters show moderate to little generalizability across tasks, and that their interpretation strongly depends on task context. Support for these claims could be further strengthened through additional simulations and by providing greater methodological detail.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. Differentiation signals from glia are fine-tuned to set neuronal numbers during development

   This article has 5 authors:

   1. Anadika R Prasad
   2. Inês Lago-Baldaia
   3. Matthew P Bostock
   4. Zaynab Housseini
   5. Vilaiwan M Fernandes

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will be of interest to cell and developmental biologists and neuroscientists. It addresses the question of how the number of connecting neurons in a circuit is matched whilst maintaining topography. It shows that non-autonomous control of neuronal number involves a relay mechanism through two distinct glial cell types, enabling the specification of distinct neuronal classes.

     This manuscript was co-submitted with: https://www.biorxiv.org/content/10.1101/2022.02.21.481306v1

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

7. Variable paralog expression underlies phenotype variation

   This article has 9 authors:

   1. Raisa Bailon-Zambrano
   2. Juliana Sucharov
   3. Abigail Mumme-Monheit
   4. Matthew Murry
   5. Amanda Stenzel
   6. Anthony T Pulvino
   7. Jennyfer M Mitchell
   8. Kathryn L Colborn
   9. James T Nichols

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this elegant genetic study, Bailon-Zambrano and colleagues draw on classical genetic concepts to address the clinically pertinent question of how genetic variants in the same gene can yield wildly different phenotypes in different individuals. From their case study they conclude that a major contributor is variation in paralog expression. The question addressed is of great interest to evolutionary and developmental biologists in general and to those studying the evolution of developmental mechanisms in particular.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3

   This article has 10 authors:

   1. Jack Rhodes
   2. Andra-Octavia Roman
   3. Marta Bjornson
   4. Benjamin Brandt
   5. Paul Derbyshire
   6. Michele Wyler
   7. Marc W Schmid
   8. Frank LH Menke
   9. Julia Santiago
   10. Cyril Zipfel

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Beginning with transcriptome data, Rhodes et al. identify a new family of peptides with signalling function called CTNIP in the model plant Arabidopsis thaliana. They use an elegant biochemical capture approach to pinpoint the SERK-dependent LRR receptor kinase HSL3 as the only receptor for these peptides. They provide convincing genetic and biochemical evidence that HSL3 binds CTNIP and that CTNIP perception triggers HSL3-dependent cytoplasmic calcium influx, ROS production and transcriptional changes. Furthermore, they provide initial evidence that the CTNIP-HSL3 module may participate in regulating root growth.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

9. Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

   This article has 11 authors:

   1. Yuexin Wang
   2. Hui Yang
   3. Anna Jia
   4. Yufei Wang
   5. Qiuli Yang
   6. Yingjie Dong
   7. Yueru Hou
   8. Yejin Cao
   9. Lin Dong
   10. Yujing Bi
   11. Guangwei Liu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Wang and colleagues report that the expression of Piezo1 (an ion channel and mechanical sensor) is upregulated on dendritic cells (DC) under conditions of inflammation/high environmental stiffness resulting in DC activation, maturation, and skewing in DC functional polarity and metabolism. They show that Piezo1 knockout results in faster tumor progression and accumulation of more regulatory T cells, and that Smad3 and STAT4 are involved in DC-mediated differentiation of Th1 and Treg. Overall this represents a mechanistic advance in our understanding of DC biology as it relates to cancer and other human pathologies.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Learning-related contraction of gray matter in rodent sensorimotor cortex is associated with adaptive myelination

    This article has 10 authors:

    1. Tomas Mediavilla
    2. Özgün Özalay
    3. Héctor M Estévez-Silva
    4. Bárbara Frias
    5. Greger Orädd
    6. Fahad R Sultan
    7. Claudio Brozzoli
    8. Benjamín Garzón
    9. Martin Lövdén
    10. Daniel J Marcellino

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This is a useful study employing a well-established one-pawed reaching/grasping paradigm for fine-motor skill learning to assess if learning is associated with cortical structural changes as assessed by longitudinal MRI measurements in mice. The authors report a non-linear time course of MRI signal changes representing a decrease in grey matter and an increase in white matter volumes in the cerebral cortex and other regions. The authors ascribe these changes to increased myelination, a conclusion that is supported by quantitative immunolabelling for the myelin protein MBP. These results represent an interesting addition to the literature around myelination changes associated with learning/activity (adaptive myelination). Additional histological analysis of changes in myelination would bolster support for the authors' conclusions.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife