eLife

Latest preprint reviews

1. Putting perception into action with inverse optimal control for continuous psychophysics

   This article has 2 authors:

   1. Dominik Straub
   2. Constantin A Rothkopf

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The paper presents a Bayesian model framework for estimating individual perceptual uncertainty from continuous tracking data, taking into account motor variability, action cost, and possible misestimation of the generative dynamics. While the contribution is mostly technical, the analyses are well done and clearly explained. The paper provides therefore a didactic resource for students wishing to implement similar models on continuous action data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy

   This article has 11 authors:

   1. Nozomu Yoshioka
   2. Masayuki Kurose
   3. Masato Yano
   4. Dang Minh Tran
   5. Shujiro Okuda
   6. Yukiko Mori-Ochiai
   7. Masao Horie
   8. Toshihiro Nagai
   9. Ichizo Nishino
   10. Shinsuke Shibata
   11. Hirohide Takebayashi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors demonstrate that isoform-specific Dystonin-b (Dst-b) mutant mice show significant myopathy in skeletal and cardiac muscle at older ages without the peripheral neuropathy or post-natal lethality that are commonly observed by loss of function of the DST gene. The study provides novel information about the role of the Dst-b isoform in maintaining skeletal and cardiac muscle health. In addition, the study suggests that isoform-specific mutations in Dst-b gene may cause some hereditary skeletal and cardiac myopathies.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations

   This article has 16 authors:

   1. Basel Maher Al-Barghouthi
   2. Will T Rosenow
   3. Kang-Ping Du
   4. Jinho Heo
   5. Robert Maynard
   6. Larry Mesner
   7. Gina Calabrese
   8. Aaron Nakasone
   9. Bhavya Senwar
   10. Louis Gerstenfeld
   11. James Larner
   12. Virginia Ferguson
   13. Cheryl Ackert-Bicknell
   14. Elise Morgan
   15. David Brautigan
   16. Charles R Farber

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of broad interest to geneticists and bone biologists because it describes a method to filter candidate genes, identified from GWAS, and pinpoint the gene that affects bone biology. This method identified a gene with a previously unknown role in bone biology and the authors showed that its loss reduces bone mineral density, supporting the key claims in the paper.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

4. Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

   This article has 14 authors:

   1. James Boot
   2. Gabriel Rosser
   3. Dailya Kancheva
   4. Claire Vinel
   5. Yau Mun Lim
   6. Nicola Pomella
   7. Xinyu Zhang
   8. Loredana Guglielmi
   9. Denise Sheer
   10. Michael Barnes
   11. Sebastian Brandner
   12. Sven Nelander
   13. Kiavash Movahedi
   14. Silvia Marino

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Glioblastoma is a challenging disease with a high level of heterogeneity. Here the authors use global methylation profiling of tumor-initiating cells and matched iNSCs and identify a subgroup of hypomethylated tumors with an astrocytic phenotype. Understanding heterogeneity in glioblastoma is a major challenge, and the identification of alterations of functional and clinical impact is of importance to the field.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. Multiple ciliary localization signals control INPP5E ciliary targeting

   This article has 13 authors:

   1. Dario Cilleros-Rodriguez
   2. Raquel Martin-Morales
   3. Pablo Barbeito
   4. Abhijit Deb Roy
   5. Abdelhalim Loukil
   6. Belen Sierra-Rodero
   7. Gonzalo Herranz
   8. Olatz Pampliega
   9. Modesto Redrejo-Rodriguez
   10. Sarah C Goetz
   11. Manuel Izquierdo
   12. Takanari Inoue
   13. Francesc R Garcia-Gonzalo

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of interest to developmental and cell biologists exploring cilia dynamics and ciliopathies. The authors address the molecular mechanisms by which INPP5E, a phosphoinositide phosphatase essential for regulating cilia function, is targeted to the primary cilium of cultured mammalian cells. Using immunoprecipitation, ciliary localization, phosphatase activity assays in combination with structural modelling, the authors identify four motifs important for ciliary localization of INPP5E, and uncover several novel and important interactions with other ciliary proteins providing a likely mechanism for ciliary targeting. The claims are generally well supported by the data, but some additional data acquisition and analysis are required to fully support the authors' conclusions and provide a conceptual advance in the field.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

6. Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

   This article has 3 authors:

   1. Daria Lukasz
   2. Alisha Beirl
   3. Katie Kindt

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Hair cell activity has been postulated to underlie their vulnerability to environmental insult including toxin exposure. Previous work has been confounded by the fact that reducing mechanotransduction also reduces entry of toxic chemicals. Here Lukasz and colleagues test these ideas by examining the vulnerability of zebrafish mutants with impaired synaptic activity, thought to be a major driver of neuronal metabolic load.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

7. Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple‐negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta

   This article has 19 authors:

   1. Yunting Jian
   2. Lingzhi Kong
   3. Hongyi Xu
   4. Yawei Shi
   5. Xinjian Huang
   6. Wenjing Zhong
   7. Shumei Huang
   8. Yue Li
   9. Dongni Shi
   10. Yunyun Xiao
   11. Muwen Yang
   12. Siqi Li
   13. Xiangfu Chen
   14. Ying Ouyang
   15. Yameng Hu
   16. Xin Chen
   17. Libing Song
   18. Runyi Ye
   19. Weidong Wei

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript presents data that high expression of Protein Phosphatase 1 (PP1) inhibitor in triple-negative breast cancer contributes to poor outcomes by downregulation of an important kinase, GSK3β. The study clearly demonstrates that changes in PPP1R14C expression alter the behaviour of the studied cancer cells and mouse models and proposes a mechanism linking PP1 inhibitor to GSK3β. If this mechanism were substantiated, this would enhance our understanding of the pathophysiology of this important disease and might suggest new treatment options.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Mir155 regulates osteogenesis and bone mass phenotype via targeting S1pr1 gene

   This article has 15 authors:

   1. Zhichao Zheng
   2. Lihong Wu
   3. Zhicong Li
   4. Ruoshu Tang
   5. Hongtao Li
   6. Yinyin Huang
   7. Tianqi Wang
   8. Shaofen Xu
   9. Haoyu Cheng
   10. Zhitong Ye
   11. Dong Xiao
   12. Xiaolin Lin
   13. Gang Wu
   14. Richard T Jaspers
   15. Janak L Pathak

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Caner/cancer metastasis-induced bone loss-mediated fracture is a serious clinical problem. In this regard the authors have done an interesting study to show how miR155 exhibits a catabolic effect on osteogenesis and bone mass phenotype via interaction with the Sphingosine 1-phosphate receptor-1 (S1PR1) gene. The study suggests that inhibition of miR155 could be a potential strategy for bone regeneration and bone defect healing.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

9. The spatiotemporal patterns of major human admixture events during the European Holocene

   This article has 3 authors:

   1. Manjusha Chintalapati
   2. Nick Patterson
   3. Priya Moorjani

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript presents DATES, a method to infer the timing of admixture events using genetic data from present-day or ancient individuals. This is a robust method that is useful in the field of paleogenomics and outperforms existing methods. In this manuscript, DATES is applied to >1000 ancient human genomes to characterize major admixture events during the European Holocene. This work will be of interest to scholars in the fields of population genetics, paleogenomics, archeology, biological anthropology, and history.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Elevated brain-derived cell-free DNA among patients with first psychotic episode – a proof-of-concept study

    This article has 13 authors:

    1. Asael Lubotzky
    2. Ilana Pelov
    3. Ronen Teplitz
    4. Daniel Neiman
    5. Adama Smadja
    6. Hai Zemmour
    7. Sheina Piyanzin
    8. Bracha-Lea Ochana
    9. Kirsty L Spalding
    10. Benjamin Glaser
    11. Ruth Shemer
    12. Yuval Dor
    13. Yoav Kohn

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This study explores the utility of cell free DNA analysis in non-malignant disease using epigenomic methods. By using brain specific methylation loci the authors identify higher levels of brain-related DNA in the plasma of patients with acute psychotic illness compared with non-disease controls. This paper will be of interest to readers in the field of liquid biopsy.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife