eLife

Latest preprint reviews

1. Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

   This article has 8 authors:

   1. Viktor J Olah
   2. Annie M Goettemoeller
   3. Sruti Rayaprolu
   4. Eric B Dammer
   5. Nicholas T Seyfried
   6. Srikant Rangaraju
   7. Jordane Dimidschstein
   8. Matthew JM Rowan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Using computational modeling and dynamic clamp recordings, this work supports the concept that hyperexcitability of cortical circuits in a familial mouse model of Alzheimer's disease is caused by impairments of biophysical properties of Kv3 channels in parvalbumin-positive cortical interneurons. Overall, the work is clear and interesting but some further analysis is required to provide compelling support to the central claims.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

2. Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

   This article has 12 authors:

   1. Magdalena L Russell
   2. Aisha Souquette
   3. David M Levine
   4. Stefan A Schattgen
   5. E Kaitlynn Allen
   6. Guillermina Kuan
   7. Noah Simon
   8. Angel Balmaseda
   9. Aubree Gordon
   10. Paul G Thomas
   11. Frederick A Matsen
   12. Philip Bradley

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study demonstrates that differences in areas outside the regions that encode the TCR genes can affect the properties of TCRs that get made. This paper will be of interest to a broad swathe of immunologists who study such variable lymphocyte receptors. It combines several large datasets in an extremely statistically rigorous analysis, producing results consistent with but substantially expanding upon the prior knowledge of the field.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

3. Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family

   This article has 4 authors:

   1. Karthik Ramanadane
   2. Monique S Straub
   3. Raimund Dutzler
   4. Cristina Manatschal

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:
     This work elegantly fuses cryo-EM, x-ray crystallography, and in vitro transport experiments to describe the structural basis for functional diversity in the SLC11/NRAMP family of membrane transporters. This work identifies factors responsible for selectivity of classical NRAMPS for transition metal ions (Fe, Mn) and the NRMT clade for alkali metal ion (Mg). Although selectivity is much discussed in transport of divalent metal ions, this is an outstanding example of a study that gets to the bottom of the structural determinants governing this behavior.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

4. Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity

   This article has 5 authors:

   1. Germán D Carrasquilla
   2. Mario García-Ureña
   3. Tove Fall
   4. Thorkild IA Sørensen
   5. Tuomas O Kilpeläinen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript by Carrasquilla and colleagues applied Mendelian Randomization (MR) techniques to study causal relationship of physical activity and obesity. Their results support the causal effects of physical activity on obesity, and bi-directional causal effects of sedentary time and obesity. One strength of this work is the use of CAUSE, a recently developed MR method that is robust to common violations of MR assumptions. The conclusion reached could potentially have a large impact on an important public health problem.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle

   This article has 9 authors:

   1. Xueyong Wang
   2. Murad Nawaz
   3. Chris DuPont
   4. Jessica H Myers
   5. Steve RA Burke
   6. Roger A Bannister
   7. Brent D Foy
   8. Andrew A Voss
   9. Mark M Rich

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This addresses an important area of excitation contraction coupling failure of potential clinical translational importance. They report that progressive depolarization of the resting potential upon excitation contraction coupling results in a persistence of action potential generation in the face of a failure of Ca2+ release.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study

   This article has 9 authors:

   1. Zuzanna Nowicka
   2. Bartłomiej Tomasik
   3. David Kozono
   4. Konrad Stawiski
   5. Thomas Johnson
   6. Daphne Haas-Kogan
   7. Marek Ussowicz
   8. Dipanjan Chowdhury
   9. Wojciech Fendler

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Nowicka et al., evaluated radiation dose and time dependent changes in the levels of selected serum miRNAs in human patients who received partial or complete myeloablative total body irradiation (TBI) and propose a panel of circulating miRNAs as potential radiation biodoismeters. The team employed next generation sequencing approach for discovery (or rediscovery) and quantification of selected responders by qRT-PCR using non-responsive miRNAs purified from exosomes in serum for evaluation of relative changes. Excellent bioinformatics and bio statistical methods are employed. However, critical biomarkers they propose as radiation biodosimeters have already been identified and published earlier. There is little novelty here and the translational significance of the study is moderate.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Ecological and social pressures interfere with homeostatic sleep regulation in the wild

   This article has 4 authors:

   1. J Carter Loftus
   2. Roi Harel
   3. Chase L Núñez
   4. Margaret C Crofoot

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This article will be of interest to behavioral ecologists studying activity patterns in wild animals. Using accelerometry, rather than polysomnography, opens up exciting opportunities for studying animal sleep under natural conditions for relatively long periods.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. Oligogenic heterozygous inheritance of sperm abnormalities in mouse

   This article has 17 authors:

   1. Guillaume Martinez
   2. Charles Coutton
   3. Corinne Loeuillet
   4. Caroline Cazin
   5. Jana Muroňová
   6. Magalie Boguenet
   7. Emeline Lambert
   8. Magali Dhellemmes
   9. Geneviève Chevalier
   10. Jean-Pascal Hograindleur
   11. Charline Vilpreux
   12. Yasmine Neirijnck
   13. Zine-Eddine Kherraf
   14. Jessica Escoffier
   15. Serge Nef
   16. Pierre F Ray
   17. Christophe Arnoult

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Oligogenic inheritance is likely to be an important mode of disease risk for many male infertility traits, but few validated examples exist. This clear documentation of oligogenic effects on mouse sperm is significant for both the sperm abnormality field and for the broader male infertility community.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

9. P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure

   This article has 12 authors:

   1. Biliana Marcheva
   2. Benjamin J Weidemann
   3. Akihiko Taguchi
   4. Mark Perelis
   5. Kathryn Moynihan Ramsey
   6. Marsha V Newman
   7. Yumiko Kobayashi
   8. Chiaki Omura
   9. Jocelyn E Manning Fox
   10. Haopeng Lin
   11. Patrick E Macdonald
   12. Joseph Bass

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Circadian disruption is widespread in our modern 24/7 society, leading to an increased prevalence of common diseases including type 2 diabetes. The authors conducted an unbiased screen for small-molecule compounds that can restore the attenuated insulin secretion from pancreatic beta cells caused by a disrupted circadian clock. They identified ivermectin and its clock-controlled target, the P2Y1 receptor, which regulate glucose-stimulated Ca2+ influx and insulin secretion in beta cells.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia

    This article has 12 authors:

    1. Jong S Park
    2. Austin M Gabel
    3. Polina Kassir
    4. Lois Kang
    5. Prableen K Chowdhary
    6. Afia Osei-Ntansah
    7. Neil D Tran
    8. Soujanya Viswanathan
    9. Bryanna Canales
    10. Pengfei Ding
    11. Young-Sam Lee
    12. Rachel Brewster

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The manuscript details the function of the N-Myc downstream regulated gene 1 (NDRG1) during induced hypoxia using the anoxic developing zebrafish as a model system. With some additional support for the central claim of a switch for metabolic suppression, this paper will be of interest to scientists with a focus on kidney development, factors that regulate hypoxic survival, and metabolism in response to stress conditions.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife