eLife

Latest preprint reviews

1. Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry

   This article has 5 authors:

   1. Xenia Grande
   2. Magdalena M Sauvage
   3. Andreas Becke
   4. Emrah Düzel
   5. David Berron

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Grande and colleagues provide new insights into how different regions of the entorhinal cortex functionally interact with specific cortical brain areas and how, in turn, subregions of the entorhinal cortex interact with the hippocampus during 'scene' and 'object' processing. This paper is relevant to cognitive neuroscientists with an interest in the entorhinal cortex - hippocampal pathways and 'scene' and 'object' representation in the medial temporal lobe. The study is well-motivated, well-designed and appropriately analysed to address the research questions. Most conclusions of the paper are well supported by the data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

2. Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

   This article has 3 authors:

   1. Mahlon A Collins
   2. Gemechu Mekonnen
   3. Frank Wolfgang Albert

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors use an elegant experimental design to study genetic variation in the ubiquitin-proteasome degradation system in yeast. They identify a large number of QTLs for naturally occurring variation, and they elucidate the causal variants and likely functional mechanisms of several of these. The paper illustrates an innovative new approach to high-throughput QTL mapping for specific molecular processes and it will be of interest to colleagues aiming to harness natural variation for understanding a range of biological processes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial

   This article has 40 authors:

   1. Nicolás MS Gálvez
   2. Gaspar A Pacheco
   3. Bárbara M Schultz
   4. Felipe Melo-González
   5. Jorge A Soto
   6. Luisa F Duarte
   7. Liliana A González
   8. Daniela Rivera-Pérez
   9. Mariana Ríos
   10. Roslye V Berrios
   11. Yaneisi Vázquez
   12. Daniela Moreno-Tapia
   13. Omar P Vallejos
   14. Catalina A Andrade
   15. Guillermo Hoppe-Elsholz
   16. Carolina Iturriaga
   17. Marcela Urzua
   18. María S Navarrete
   19. Álvaro Rojas
   20. Rodrigo Fasce
   21. Jorge Fernández
   22. Judith Mora
   23. Eugenio Ramírez
   24. Aracelly Gaete-Argel
   25. Mónica L Acevedo
   26. Fernando Valiente-Echeverría
   27. Ricardo Soto-Rifo
   28. Daniela Weiskopf
   29. Alba Grifoni
   30. Alessandro Sette
   31. Gang Zeng
   32. Weining Meng
   33. CoronaVacCL03 Study Group
   34. José V González-Aramundiz
   35. Marina Johnson
   36. David Goldblatt
   37. Pablo A González
   38. Katia Abarca
   39. Susan M Bueno
   40. Alexis M Kalergis

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript described the effects of two different CoronaVac vaccination schedules in a Chilean adult population. They find that a 0 and 28-day two-dose schedule produced superior levels of neutralizing antibodies and antibodies with a great breadth of interaction across variants compared to a 0 and 14-day two-dose schedule. They find no differences in T cell responses or total antibody levels between the two groups. These findings demonstrate that a short two-week two-dose interval should provide sufficient immunity to reduce the likelihood of serious outcomes during a COVID infection.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution

   This article has 37 authors:

   1. Geoffrey W Meissner
   2. Aljoscha Nern
   3. Zachary Dorman
   4. Gina M DePasquale
   5. Kaitlyn Forster
   6. Theresa Gibney
   7. Joanna H Hausenfluck
   8. Yisheng He
   9. Nirmala A Iyer
   10. Jennifer Jeter
   11. Lauren Johnson
   12. Rebecca M Johnston
   13. Kelley Lee
   14. Brian Melton
   15. Brianna Yarbrough
   16. Christopher T Zugates
   17. Jody Clements
   18. Cristian Goina
   19. Hideo Otsuna
   20. Konrad Rokicki
   21. Robert R Svirskas
   22. Yoshinori Aso
   23. Gwyneth M Card
   24. Barry J Dickson
   25. Erica Ehrhardt
   26. Jens Goldammer
   27. Masayoshi Ito
   28. Dagmar Kainmueller
   29. Wyatt Korff
   30. Lisa Mais
   31. Ryo Minegishi
   32. Shigehiro Namiki
   33. Gerald M Rubin
   34. Gabriella R Sterne
   35. Tanya Wolff
   36. Oz Malkesman
   37. FlyLight Project Team

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study bridges the gap between connectomic data from the fly hemibrain and driver lines needed for functional experiments through a new freely available computational tool, NeuronBridge. It demonstrates that this software provides users with the ability to identify the same neurons within different driver lines, and the opportunity to match expression of neurons in a driver line with those in a connectomic database. Overall, this manuscript does a commendable job of describing an important resource for the community, which will hopefully be built upon via collaborative science of many groups as the field develops.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

   This article has 17 authors:

   1. Christiane Pleuger
   2. Dingding Ai
   3. Minea L Hoppe
   4. Laura T Winter
   5. Daniel Bohnert
   6. Dominik Karl
   7. Stefan Guenther
   8. Slava Epelman
   9. Crystal Kantores
   10. Monika Fijak
   11. Sarina Ravens
   12. Ralf Middendorff
   13. Johannes U Mayer
   14. Kate L Loveland
   15. Mark Hedger
   16. Sudhanshu Bhushan
   17. Andreas Meinhardt

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript addresses a long-standing question regarding the highly variable cellular composition and functions as well as immune environments along the epididymis. Using multiple mouse models (bacterial infection and parabiosis between WT and Ccr2 KO) in conjunction with powerful scRNA-seq analyses, the authors provided solid evidence supporting the notion that resident immune cells are strategically positioned along the epididymal duct, potentially providing different immunological environments required for sperm maturations and elimination of pathogens ascending the urogenital tract.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Coding of latent variables in sensory, parietal, and frontal cortices during closed-loop virtual navigation

   This article has 8 authors:

   1. Jean-Paul Noel
   2. Edoardo Balzani
   3. Eric Avila
   4. Kaushik J Lakshminarasimhan
   5. Stefania Bruni
   6. Panos Alefantis
   7. Cristina Savin
   8. Dora E Angelaki

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript by Noel et al reports parallel neurophysiological responses from the three brain areas MST, 7a and dlPFC of monkeys during a novel behavioural paradigm developed by the same group previously. The continual nature of this paradigm with a closed action-perception loop makes the animal behaviour more naturalistic compared to classical paradigms with artificial breaks between sensory stimulation and action. Findings of neurophysiology under such a paradigm are novel and of broad interest to cognitive and systems neuroscientists. The data presented in the paper support the claim of distributed neural coding in which task-specific sub-networks may form.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

   This article has 7 authors:

   1. Phoebe M Kirkwood
   2. Douglas A Gibson
   3. Isaac Shaw
   4. Ross Dobie
   5. Olympia Kelepouri
   6. Neil C Henderson
   7. Philippa TK Saunders

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an important and delicately designed study that uses integrated tools to reveal underlying mechanisms of repair of the endometrium at menstruation. It combines single cell sequencing analysis and lineage tracing technologies to strongly prove that repair-specific cells originate from the fibroblast cell clusters and PDGFRα+ endometrial fibroblasts undergo MET and can become incorporated into the luminal epithelium of the post repair tissue.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Connexin 43 hemichannels regulate mitochondrial ATP generation, mobilization, and mitochondrial homeostasis against oxidative stress

   This article has 6 authors:

   1. Jingruo Zhang
   2. Manuel A Riquelme
   3. Rui Hua
   4. Francisca M Acosta
   5. Sumin Gu
   6. Jean X Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript is well organized and clearly written. The discussion provides the required information to easily understand the relevance of each finding. the authors demonstrated using an osteocyte cell model that connexin43 is localized to mitochondria and that this is enhanced in response to oxidative stress. Several lines of evidence were presented showing that mitochondrial connexin43 forms functional hemichannels and that connexin43 is required for optimal mitochondrial respiration and ATP generation. These aspects were major strengths of the study.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

   This article has 11 authors:

   1. Vi T Tang
   2. Joseph McCormick
   3. Bolin Xu
   4. Yawei Wang
   5. Huan Fang
   6. Xiao Wang
   7. David Siemieniak
   8. Rami Khoriaty
   9. Brian T Emmer
   10. Xiao-Wei Chen
   11. David Ginsburg

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     By the use of liver specific gene knock-out approaches Tang et al have clearly documented an important role for an endoplasmic reticulum sorting receptor, SURF4, in the efficient secretion of PCSK9, a protein in circulation that binds to and enhances the intracellular uptake and degradation of the low density lipoprotein receptor. As a consequence of liver specific knock-outs, adult mice survive well with an exceptionally lower level of circulating cholesterol, triglycerides and various lipoproteins. These compelling results reinforce the prospect for the development of therapeutic approaches in cholesterol and LDL reduction by targeting the intracellular association of PCSK9 and the SURF4 receptor. The work is elegant and complete with the only concern that some of the work and results overlap work published previously by some of these authors.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands

    This article has 7 authors:

    1. Zhiyao Gao
    2. Li Zheng
    3. Katya Krieger-Redwood
    4. Ajay Halai
    5. Daniel S Margulies
    6. Jonathan Smallwood
    7. Elizabeth Jefferies

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This work provides substantial new insights into how semantic association strength influences the function and relationships across brain regions along a topographical structure of cerebral cortex. A principal gradient with the separation of default mode network from sensory-motor systems represents a hallmark of the retrieval of strong conceptual links. This study will be of interest to cognitive neuroscientists, especially those who are interested in semantic cognition.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife