eLife

Latest preprint reviews

1. CCL28 modulates neutrophil responses during infection with mucosal pathogens

   This article has 21 authors:

   1. Gregory T Walker
   2. Araceli Perez-Lopez
   3. Steven Silva
   4. Michael H Lee
   5. Elisabet Bjånes
   6. Nicholas Dillon
   7. Stephanie L Brandt
   8. Romana R Gerner
   9. Karine Melchior
   10. Grant J Norton
   11. Felix A Argueta
   12. Frenchesca Dela Pena
   13. Lauren Park
   14. Victor A Sosa-Hernandez
   15. Rodrigo Cervantes-Diaz
   16. Sandra Romero-Ramirez
   17. Monica Cartelle Gestal
   18. Jose L Maravillas-Montero
   19. Sean-Paul Nuccio
   20. Victor Nizet
   21. Manuela Raffatellu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, Perez-Lopez and colleagues examine an important function of the chemokine CCL28 in mucosal host defenses against the gut bacterial pathogen Salmonella Typhimurium and lung pathogen Acinetobacter baumanii. They find that CCL28-CCR3 axis regulates neutrophil recruitment and function, and promotes bacterial clearance in one infectious context but exacerbates disease against the other pathogen. Therefore, CCL28 plays a critical role in mucosal immunity and neutrophil biology that differentially affects host defenses against pathogens.

   Reviewed by eLife

2. Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics

   This article has 6 authors:

   1. Hui Li
   2. Jun Yang
   3. Su-fang Kuang
   4. Huan-zhe Fu
   5. Hui-ying Lin
   6. Bo Peng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study explored the influence of magnesium on phenotypic antibiotic resistance in two Vibrio model bacteria. This research is fundamental for revealing the phenotypic antibiotic resistance mechanism utilized by the specified model bacteria in elevated levels of magnesium. The study produced solid evidence indicating that in high concentrations of magnesium, the efficacy of selected antibiotics was diminished due to decreased biosynthesis of unsaturated fatty acids and PE, along with an increase in the biosynthesis of PG.

   Reviewed by eLife

3. Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

   This article has 13 authors:

   1. Zewei Zhao
   2. Longyun Hu
   3. Bigui Song
   4. Tao Jiang
   5. Qian Wu
   6. Jiejing Lin
   7. Xiaoxiao Li
   8. Yi Cai
   9. Jin Li
   10. Bingxiu Qian
   11. Siqi Liu
   12. Jilu Lang
   13. Zhonghan Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study identifies the adhesion G-protein-coupled receptor A3 (ADGRA3) as a potential target for activating adaptive thermogenesis in white and brown adipose tissue, providing valuable information for scientists in the field of adipose tissue biology and metabolism. Although the authors have addressed some concerns raised by reviewers, the interpretations remain somewhat limited, and the work is deemed incomplete. The evidence supporting ADGRA3's role in thermogenesis is insufficient, necessitating more rigorous experiments to validate the receptor's relevance in adipose tissue. Additionally, the lack of experiments using primary cultures, despite feedback from multiple reviewers, highlights significant shortcomings.

   Reviewed by eLife

4. Direct and indirect salt effects on homotypic phase separation

   This article has 3 authors:

   1. Matt MacAinsh
   2. Souvik Dey
   3. Huan-Xiang Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this potentially important study, the authors conducted atomistic simulations to probe the salt-dependent phase separation of the low-complexity domain of hnRN-PA1 (A1-LCD). The authors have identified both direct and indirect mechanisms of salt modulation, provided explanations for four distinct classes of salt dependence, and proposed a model for predicting protein properties from amino acid composition. There is a range of opinions regarding the strength of evidence, with some considering the evidence as incomplete due to the limitations in the length and statistical errors of the computationally intense atomistic MD simulations.

   Reviewed by eLife

5. Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex: Implications for renal dysfunction

   This article has 24 authors:

   1. Jittoku Ihara
   2. Yibin Huang
   3. Yoichi Takami
   4. Yoichi Nozato
   5. Toshimasa Takahashi
   6. Akemi Kakino
   7. Cheng Wang
   8. Ziwei Wang
   9. Yu Guo
   10. Weidong Liu
   11. Nanxiang Yin
   12. Ryoichi Ohara
   13. Taku Fujimoto
   14. Shino Yoshida
   15. Kazuhiro Hongyo
   16. Hiroshi Koriyama
   17. Hiroshi Akasaka
   18. Hikari Takeshita
   19. Shinsuke Sakai
   20. Kazunori Inoue
   21. Yoshitaka Isaka
   22. Hiromi Rakugi
   23. Tatsuya Sawamura
   24. Koichi Yamamoto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful in vitro evidence to support a mechanism whereby dyslipidemia could accelerate renal functional decline through the activation of the AT1R/LOX1 complex by oxLDL and AngII. As such, it improves the knowledge regarding the complex interplay between dyslipidemia and renal disease and provides a solid basis for the discovery of novel therapeutic strategies for patients with lipid disorders. The methods, data, and analyses support the presented findings, although the observed variability and need for further in vivo validation require additional research in this key area.

   Reviewed by eLife

6. Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

   This article has 12 authors:

   1. Xiexiang Shao
   2. Xingzuan Lin
   3. Hao Zhou
   4. Minhui Wang
   5. Lili Han
   6. Xin Fu
   7. Sheng Li
   8. Siyuan Zhu
   9. Shenao Zhou
   10. Wenjun Yang
   11. Jianhua Wang
   12. Ping Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors made an important finding that CD29+/CD56+ progenitor cells isolated from human muscles have the potential to differentiate to tendons in vitro and in vivo. The author's approach to testing the tenogenesis of the CD29+/CD56+ progenitors is solid, and the conclusion is supported by enough evidence with minor flaws. This work will be of interest to the population who need tendon regeneration from their injury.

   Reviewed by eLife

7. Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs

   This article has 15 authors:

   1. Shuo Chao
   2. Jun Lu
   3. Li-Jun Li
   4. Hong-Yan Guo
   5. Kui-Peng Xu
   6. Ning Wang
   7. Shu-Xian Zhao
   8. Xiao-Wen Jin
   9. Shao-Ge Wang
   10. Shen Yin
   11. Wei Shen
   12. Ming-Hui Zhao
   13. Gui-An Huang
   14. Qing-Yuan Sun
   15. Zhao-Jia Ge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports important findings on the impact of maternal obesity on offspring metabolism. It presents solid evidence that maternal obesity induces genomic methylation alterations in oocytes, which can be partly transmitted to F2 in females, and that melatonin is involved in regulating the hyper-methylation of high fat diet oocytes by increasing the expression of DNMTs via the cAMP/PKA/CREB pathway. This study would be of interest to biologists in the fields of epigenetics and metabolism.

   Reviewed by eLife

8. Decoding the physics of observed actions in the human brain

   This article has 2 authors:

   1. Moritz F Wurm
   2. Doruk Yiğit Erigüç

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In an important fMRI study with an elegant experimental design and rigorous cross-decoding analyses, this work shows a solid dissociation between two parietal regions in visually processing actions. Specifically, aIPL is found to be sensitive to the causal effects of observed actions, while SPL is sensitive to the patterns of body motion involved in those actions. Additional analysis and explanation would help to determine the strength of evidence and the mechanistic underpinnings would benefit from closer consideration. Nevertheless, the work will be of broad interest to cognitive neuroscientists, particularly vision and action researchers.

   Reviewed by eLife

9. Muscarinic receptors mediate motivation via preparatory neural activity in humans

   This article has 6 authors:

   1. John P Grogan
   2. Matthias Raemaekers
   3. Maaike MH van Swieten
   4. Alexander L Green
   5. Martin J Gillies
   6. Sanjay G Manohar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors have reported an important study in which they use a double-blind design to explore pharmacological manipulations in the context of a behavioral task. While the sample size is small, the use of varied methodology, including electrophysiology, behavior, and pharmacology, makes this manuscript particularly notable. Overall, the findings are solid and motivate future explanations into the relationships between acetylcholine and motivation.

   Reviewed by eLife

10. Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

    This article has 10 authors:

    1. Bin Zheng
    2. Meimei Duan
    3. Yifen Huang
    4. Shangchen Wang
    5. Jun Qiu
    6. Zhuojian Lu
    7. Lichao Liu
    8. Guojin Tang
    9. cheng Lin
    10. Peng Zheng

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This work presents important findings regarding the interaction of the monkeypox virus (MPXV) attachment H3 protein with the cellular receptor heparan sulfate and the use of this information to develop antivirals potentially effective against all orthopoxviruses. Using a combination of state-of-the art computational and wet experiments the authors present solid evidence to sustain their claims. These results will interest those working on basic orthopoxviruses biology and antiviral development.

    Reviewed by eLife