eLife

Latest preprint reviews

1. Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum

   This article has 11 authors:

   1. Sophia S Loschky
   2. Giovanna Maria Spano
   3. William Marshall
   4. Andrea Schroeder
   5. Kelsey Marie Nemec
   6. Shannon Sandra Schiereck
   7. Luisa de Vivo
   8. Michele Bellesi
   9. Sebastian Weyn Banningh
   10. Giulio Tononi
   11. Chiara Cirelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides compelling structural evidence on regulation of cerebellar synapses by sleep-wake states. The authors used serial block face scanning electron microscopy to obtain 3D reconstruction of more than 7,000 spines and their parallel fiber synapses in the mouse posterior vermis. The analysis shows that sleep increases the fraction of the 'naked' spines that don't carry a presynaptic partner at Purkinje cells. The authors propose that sleep promotes the pruning of branched synapses to single spines. This is an elegant and thorough study and the observations are important in light of the circuit-specific mechanisms by which sleep modulate synaptic structure and function.

   Reviewed by eLife

2. Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes

   This article has 8 authors:

   1. Tuo Shi
   2. Marielle O Beaulieu
   3. Lauren M Saunders
   4. Peter Fabian
   5. Cole Trapnell
   6. Neil Segil
   7. J Gage Crump
   8. David W Raible

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes transcriptomic profiles of sensory and non-sensory cells of the zebrafish inner ear at single-cell resolution in embryonic through adult stages. These solid results catalogue transcriptomic data and show evidence that distinct cell subtypes exist between cells of the ear and the lateral line as well as within subcellular compartments in the inner ear. These findings provide information toward comparison studies of inner ear hair cell function in zebrafish and mammals.

   Reviewed by eLife

3. Nazo, the Drosophila homolog of the NBIA-mutated protein–c19orf12, is required for triglyceride homeostasis

   This article has 7 authors:

   1. Perinthottathil Sreejith
   2. Sara Lolo
   3. Kristen R. Patten
   4. Maduka Gunasinghe
   5. Neya More
   6. Leo J. Pallanck
   7. Rajnish Bharadwaj

   Reviewed by eLife

4. Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity

   This article has 17 authors:

   1. Pascal Dominic Rem
   2. Vita Sereikaite
   3. Diego Fernández-Fernández
   4. Sebastian Reinartz
   5. Daniel Ulrich
   6. Thorsten Fritzius
   7. Luca Trovo
   8. Salomé Roux
   9. Ziyang Chen
   10. Philippe Rondard
   11. Jean-Philippe Pin
   12. Jochen Schwenk
   13. Bernd Fakler
   14. Martin Gassmann
   15. Tania Rinaldi Barkat
   16. Kristian Strømgaard
   17. Bernhard Bettler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study refuted earlier work on the same subject. The two reviewers felt the manuscript was accurate, concise, and unbiased. The experimental evidence were thorough and supported the conclusions. The reviewers concurred the overall significance and quality of the experimental research were compelling and addressed previous work on this problem.

   Reviewed by eLife

5. Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner

   This article has 10 authors:

   1. Melina Hußmann
   2. Dörte Schulte
   3. Sarah Weischer
   4. Claudia Carlantoni
   5. Hiroyuki Nakajima
   6. Naoki Mochizuki
   7. Didier YR Stainier
   8. Thomas Zobel
   9. Manuel Koch
   10. Stefan Schulte-Merker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work reveals that lymphatic vascular development can occur independent of VegfC signaling, and that genetic interactions between a large extracellular matrix protein Svep1 and Tie1 receptor are important for the development of facial lymphatics and other aspects of lymphatic vascular development. The data link Svep1 to Tie1 signaling via elegant genetic experiments and provide important insights into a complex signaling pathway that is widely utilized in vascular development. The genetic evidence is convincing in supporting the findings that Tie1 but not Tie2 interacts with Svep1 in aspects of lymphangiogenesis.

   Reviewed by eLife

6. Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization

   This article has 11 authors:

   1. Mark Gormley
   2. Tom Dudding
   3. Steven J Thomas
   4. Jessica Tyrrell
   5. Andrew R Ness
   6. Miranda Pring
   7. Danny Legge
   8. George Davey Smith
   9. Rebecca C Richmond
   10. Emma E Vincent
   11. Caroline Bull

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study linking metabolic traits and head and neck cancer risk using Mendelian randomisation. The findings, well supported by the data, were inconclusive. This work will be of interest to researchers working in head and neck cancer.

   Reviewed by eLife

7. Comprehensive re-analysis of hairpin small RNAs in fungi reveals loci with conserved links

   This article has 4 authors:

   1. Nathan R Johnson
   2. Luis F Larrondo
   3. José M Álvarez
   4. Elena A Vidal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of interest to scientists within the field of RNA silencing and evolution. The data analysis is rigorous, and the conclusions are justified by the data. The key claims of the manuscript provide a compelling approach to identifying and annotating microRNAs in fungi although there is a limitation in the functional validation of the identified miRNAs.

   Reviewed by eLife

8. Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts

   This article has 11 authors:

   1. Charlotte Guyomar
   2. Clément Bousquet
   3. Siou Ku
   4. John M Heumann
   5. Gabriel Guilloux
   6. Natacha Gaillard
   7. Claire Heichette
   8. Laurence Duchesne
   9. Michel O Steinmetz
   10. Romain Gibeaux
   11. Denis Chrétien

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study, using cryo-electron tomography represents a valuable study to the research community, to raise awareness that in vitro-assembled microtubules have more lattice defects than microtubules assembled in cell extracts. However the evidence supporting the claims was incomplete in places and there was not enough data. It is not clear how generalizable these findings are regarding tubulin assembly into microtubules.

   Reviewed by eLife

9. Lifespan extension in female mice by early, transient exposure to adult female olfactory cues

   This article has 7 authors:

   1. Michael Garratt
   2. Ilkim Erturk
   3. Roxann Alonzo
   4. Frank Zufall
   5. Trese Leinders-Zufall
   6. Scott D Pletcher
   7. Richard A Miller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study provides solid evidence for a new intervention, exposure to male vs. female olfactory cues, with an impact on female mouse lifespan. This is interesting to the field of aging research, especially since most described pro-longevity interventions to date tend to work better in male mice. Although the data broadly support the claims, additional analyses showing all probed phenotypes are needed to support all claims.

   Reviewed by eLife

10. Decline of intrinsic cerebrospinal fluid outflow in healthy humans with age detected by non-contrast spin-labeling MRI

    This article has 6 authors:

    1. Vadim Malis
    2. Won C. Bae
    3. Asako Yamamoto
    4. Linda K. McEvoy
    5. Marin A. McDonald
    6. Mitsue Miyazaki

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Malis et al present a novel sequence attempting to non-invasively measure the outflow of cerebrospinal fluid, which is potentially an important contribution given the growing interest in the glymphatic system. Their reported findings are generally consistent with previous literature and prevailing theories, however, no robust validation of the sequence is supplied rendering the evidence base incomplete.

    Reviewed by eLife