eLife

Latest preprint reviews

1. Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

   This article has 9 authors:

   1. Yulong Qiao
   2. Qiang Sun
   3. Xiaona Chen
   4. Liangqiang He
   5. Di Wang
   6. Ruibao Su
   7. Yuanchao Xue
   8. Hao Sun
   9. Huating Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study performing elegant experiments making identification of a specific regulator in skeletal muscle regeneration. It will form a foundation for further mechanistic investigation. The work is of importance in the clinical field of muscle injury and regeneration.

   Reviewed by eLife

2. Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord

   This article has 11 authors:

   1. Yuka Nakamura
   2. Miyuki Kurabe
   3. Mami Matsumoto
   4. Tokiharu Sato
   5. Satoshi Miyashita
   6. Kana Hoshina
   7. Yoshinori Kamiya
   8. Kazuki Tainaka
   9. Hitoshi Matsuzawa
   10. Nobuhiko Ohno
   11. Masaki Ueno

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors provide a new method to target mouse CSF-cNs via intracerebroventricular injection of adeno-associated virus (AAV) with a neuron-specific promoter, which enabled them to introduce any genes into CSF-cNs. By doing so, they established the structure, connectivity, and function of mouse CSF-cNs in locomotion, recapitulating the findings obtained in zebrafish and lamprey, and extending the recent observations in mice. This study is very conclusive and important for the sensorimotor field.

   Reviewed by eLife

3. Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly

   This article has 12 authors:

   1. Nicolas Macaisne
   2. Laura Bellutti
   3. Kimberley Laband
   4. Frances Edwards
   5. Laras Pitayu-Nugroho
   6. Alison Gervais
   7. Thadshagine Ganeswaran
   8. Hélène Geoffroy
   9. Gilliane Maton
   10. Julie C Canman
   11. Benjamin Lacroix
   12. Julien Dumont

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper on the regulation of microtubule dynamics during C. elegans meiosis will be of interest to scientists in the broad field of microtubule function in both mitosis and meiosis. The experiments are beautifully conducted and presented and generally support the conclusions of the paper. The results are interesting and add to our understanding of the control of microtubule dynamics at the kinetochore and its functional consequences for meiosis.

   Reviewed by eLife

4. A cell wall synthase accelerates plasma membrane partitioning in mycobacteria

   This article has 9 authors:

   1. Takehiro Kado
   2. Zarina Akbary
   3. Daisuke Motooka
   4. Ian L Sparks
   5. Emily S Melzer
   6. Shota Nakamura
   7. Enrique R Rojas
   8. Yasu S Morita
   9. M Sloan Siegrist

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper addresses an important question: the relationship between the cell wall and other, primarily lipid, based components of the cell envelope. Building on previous work, the authors provide data suggesting that the activity of a PonA2, non-essential peptidoglycan synthase, promotes membrane partitioning through its role in cell wall synthesis. While the data are consistent with this model, the reviewers felt additional experiments are necessary to fully support the authors' conclusions.

   Reviewed by eLife

5. Position representations of moving objects align with real-time position in the early visual response

   This article has 6 authors:

   1. Philippa Anne Johnson
   2. Tessel Blom
   3. Simon van Gaal
   4. Daniel Feuerriegel
   5. Stefan Bode
   6. Hinze Hogendoorn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of potential interest to any neuroscientist, given it asks how the brain compensates for its own neural transmission delays. This is a problem that runs across neuroscientific disciplines. The authors use a clever and simple design where they study this question in the context of decoding from EEG signals during visual motion processing. They robustly show evidence that the brain can indeed compensate for these delays, although all compensation appears to be afforded by early processing. The manuscript is well-written but can be strengthened by outlining its significance for the broader community as well as some further analyses.

   Reviewed by eLife

6. ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells

   This article has 6 authors:

   1. Lopamudra Sadhu
   2. Nikolaos Tsopoulidis
   3. Md Hasanuzzaman
   4. Vibor Laketa
   5. Michael Way
   6. Oliver T Fackler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study demonstrates that the two isoforms of the ARPC5 subunit (ARPC5 and ARPC5L) of the Arp2/3 complex have specific functions in regulating cytoplasmic and nuclear actin filament assembly in response to DNA replication stress and T cell receptor signaling in T lymphocytes. The data presented in the manuscript are convincing and of good technical quality, and the study provides interesting new insights into specific cellular roles of different Arp2/3 isoforms in T lymphocytes.

   Reviewed by eLife

7. Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

   This article has 5 authors:

   1. Josep Martí-Solans
   2. Aina Børve
   3. Paul Bump
   4. Andreas Hejnol
   5. Timothy Lynagh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work examines the evolutionary origins of acid-sensing ion channels (ASICs), a class of pH-sensing receptors expressed throughout the brain and body. By combining analysis of sequences, functional measurements, and measures of tissue distribution, the authors provide solid evidence that ASICs existed far earlier than previously believed. The present data indicate that ASICs emerged after the split between bilaterians (organisms with two-fold symmetry) and Cnidaria (jellyfish, anemones, corals, etc.), approximately 680 million years ago. This evolutionary and functional analysis of ASIC channels across bilaterian lineages provides relevant information about the evolution of nervous and sensory systems.

   Reviewed by eLife

8. T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

   This article has 2 authors:

   1. Mingyao Pan
   2. Bo Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports an association between TCR convergence and involvement in an antigen-specific response. TCR convergence is assessed as a potential biomarker of response to immune checkpoint blockade (ICB). From jointly analyzing TCR-seq data, single-cell RNA-seq data, and antigen-specific TCR information, the authors provided evidence that convergence is a potential indicator for ongoing T cell antigen-specific response. Overall, the analyses are sound the manuscript is well-written, and the study provides the first evidence that TCRseq alone could be used to predict clinical outcomes.

   Reviewed by eLife

9. Novel pathogen introduction triggers rapid evolution in animal social movement strategies

   This article has 5 authors:

   1. Pratik Rajan Gupte
   2. Gregory F Albery
   3. Jakob Gismann
   4. Amy Sweeny
   5. Franz J Weissing

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present a rich investigation of the evolution of social-movement rules in animal societies under pathogen pressure. The study should be of interest to a broad readership.

   Reviewed by eLife

10. VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer

    This article has 8 authors:

    1. Lei Yang
    2. Xichen Dong
    3. Zheng Liu
    4. Jinjing Tan
    5. Xiaoxi Huang
    6. Tao Wen
    7. Hao Qu
    8. Zhenjun Wang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This research focuses on the role of a long noncoding RNA VPS9D1-AS1(VPS) in colorectal cancer (CRC) immune evasion and provides evidence on how it is responsible for escape from cytotoxic T cells killing via amplifying intra-tumoral TGF-β signaling. The findings are of considerable translational significance since VPS9D1-AS1 was validated targetable in this work, and it is of broad interest to readers in cancer biology and immunotherapy.

    Reviewed by eLife