eLife

Latest preprint reviews

1. A framework for community curation of interspecies interactions literature

   This article has 6 authors:

   1. Alayne Cuzick
   2. James Seager
   3. Valerie Wood
   4. Martin Urban
   5. Kim Rutherford
   6. Kim E Hammond-Kosack

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study reports improvements in methods and tools for curating complex pathogen-host interactions. A compelling framework is described, using rigorous approaches and to considerable extent validated by the biocuration community. The developed ontologies and controlled vocabularies could be extended beyond host pathogens, e.g. ecological contexts with multi-species and multilevel interactions.

   Reviewed by eLife

2. Psychological Resilience in Adolescence as a function of Genetic Risk for Major Depressive Disorder and Alzheimer’s Disease

   This article has 2 authors:

   1. Raluca Petrican
   2. Alex Fornito

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents a multimodal approach to ascertain links between risk and resilience to depression and Alzheimer's disease in a large pediatric sample. The authors find two latent imaging variables that may be associated with resilience to adverse life events and disease risk, which show some spatial overlap with disease relevant gene-expression patterns and neurotransmitter expression. Such findings could be important for understanding mechanisms underlying resilience in neurological disorders, however, the analyses are inadequate for fully supporting the interpretation of the variables involved in these models, or for supporting some of the overall conclusions of the work.

   Reviewed by eLife

3. Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

   This article has 20 authors:

   1. Edmée Eyraud
   2. Elise Maurat
   3. Jean-Marc Sac-Epée
   4. Pauline Henrot
   5. Maeva Zysman
   6. Pauline Esteves
   7. Thomas Trian
   8. Jean-William Dupuy
   9. Alexander Leipold
   10. Antoine-Emmanuel Saliba
   11. Hugues Begueret
   12. Pierre-Olivier Girodet
   13. Matthieu Thumerel
   14. Romain Hustache-Castaing
   15. Roger Marthan
   16. Florian Levet
   17. Pierre Vallois
   18. Cécile Contin-Bordes
   19. Patrick Berger
   20. Isabelle Dupin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript by Eyraud and colleagues examines the role of interactions between fibrocytes and CD8 cells as drivers of disease progression in COPD (chronic obstructive pulmonary disease). The findings that there exist bidirectional interactions between CD8 cells and fibrocytes are supported by solid evidence that combines histology of clinical lung samples, in vitro studies obtained from circulating blood fibrocytes and CD8 cells, as well as a computational model that predicts how bidirectional interactions could promote disease progression over the course of 20 years. The study, which is based on patient samples, thus provides fundamental insights on COPD progression.

   Reviewed by eLife

4. Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

   This article has 15 authors:

   1. Giuseppina Mastrototaro
   2. Pierluigi Carullo
   3. Jianlin Zhang
   4. Beatrice Scellini
   5. Nicoletta Piroddi
   6. Simona Nemska
   7. Maria Carmela Filomena
   8. Simone Serio
   9. Carol A Otey
   10. Chiara Tesi
   11. Fabian Emrich
   12. Wolfgang A Linke
   13. Corrado Poggesi
   14. Simona Boncompagni
   15. Marie-Louise Bang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will be of interest to scientists who study cardiomyocyte homeostasis and contraction. It assesses the functional consequences of cardiomyocyte-specific knockout of Palladin, leading to the identification of a compensation mechanism when Palladin is deleted in embryogenesis, but not in adulthood. In addition, the authors identified new Palladin interactors, revealing a role for Palladin in the maintenance of intercalated disc structure.

   Reviewed by eLife

5. Metabolic consequences of various fruit-based diets in a generalist insect species

   This article has 7 authors:

   1. Laure Olazcuaga
   2. Raymonde Baltenweck
   3. Nicolas Leménager
   4. Alessandra Maia-Grondard
   5. Patricia Claudel
   6. Philippe Hugueney
   7. Julien Foucaud

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study uses untargeted metabolomics to help us understand how some herbivores are able to be generalists, rather than specializing in the metabolism of specific plant species. This is an important area, since little is known about how generalist insect species metabolize their food. In its current form, the study lacks ecological relevance due to the exclusive use of refined sampling procedures, and the metabolomic analysis is incomplete.

   Reviewed by eLife

6. Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor

   This article has 2 authors:

   1. Domenica Ippolito
   2. Dominique A Glauser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study provides solid results on the molecular signaling mechanisms of CaM kinase kinase-1 (CKK-1) in the context of the nociceptive behaviors of C. elegans. The authors report previously undescribed elements that control the nuclear/cytoplasmic shuttling of CKK-1, suggesting a complex interplay of multiple nuclear localization and export sequences. Therefore, the work will be of broad interest to scientists studying behavior, neuronal signaling, and signal transduction in general.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2022.10.28.514215

8. Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic male mice

   This article has 10 authors:

   1. Fangfang Song
   2. Won Dong Lee
   3. Tyler Marmo
   4. Xing Ji
   5. Chao Song
   6. Xueyang Liao
   7. Rebecca Seeley
   8. Lutian Yao
   9. Haoran Liu
   10. Fanxin Long

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, the authors made important progress in understanding bone metabolic defects of T2D. They have established a valuable model that could mimic some aspects of T2D in mice. Particularly, the study provided important evidence showing bone turnover and metabolism were in defects, and changes in glycolysis would rescue bone defects in T2D. Overall, the authors provide compelling evidence from dynamic histomorphometry, C13 isotype labeling in vivo, scRNA-seq, and metabolic assays to demonstrate that the defective glucose metabolism causes osteopenia associated with T2D.

   Reviewed by eLife

9. Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

   This article has 15 authors:

   1. Janani Parameswaran
   2. Nancy Zhang
   3. Elke Braems
   4. Kedamawit Tilahun
   5. Devesh C Pant
   6. Keena Yin
   7. Seneshaw Asress
   8. Kara Heeren
   9. Anwesha Banerjee
   10. Emma Davis
   11. Samantha L Schwartz
   12. Graeme L Conn
   13. Gary J Bassell
   14. Ludo Van Den Bosch
   15. Jie Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The current study provides important, mechanistic insight into the potential contribution of antisense C4G2 expanded RNA to disease in C9orf72-associated ALS/FTD. The authors convincingly demonstrate that expression of this RNA species activates the PKR/eIF2α-dependent integrated stress response. They further provide evidence that this can contribute to disease phenotypes using multiple models and post-mortem patient samples.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2022.10.25.513704