eLife

Latest preprint reviews

1. ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

   This article has 10 authors:

   1. Matthew T Schmitz
   2. Jingwen W Ding
   3. Sara Nolbrant
   4. Reed McMullen
   5. Chang N Kim
   6. Bryan J Pavlovic
   7. Tomasz J Nowakowski
   8. Trygve E Bakken
   9. Chun Jimmie Ye
   10. Alex A Pollen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study is an approach to integrating and comparing single-cell genomics data across species. The evidence supporting the conclusions of this work is solid, and ANTIPODE presents an updated methodological approach to determining how gene expression at the cell-type level has evolved. Thus, ANTIPODE should provide broad utility to studies of comparative neurogenomics and be of use to neuroscientists and evolutionary biologists.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2025.10.24.684367

3. A minimal tooth enhancer regulates dlx2b expression during zebrafish tooth formation: insights into cis-regulatory logic in organogenesis

   This article has 12 authors:

   1. William R Jackman
   2. Yujin Moon
   3. Carol K Cox
   4. Drew R Anderson
   5. Audrey A DeFusco
   6. Vy M Nguyen
   7. Sarah Y Liu
   8. Elisabeth H Carter
   9. Hana E Littleford
   10. Elizabeth K Richards
   11. Andrea L Jowdry
   12. Yann Gibert

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable findings in the study of enhancer biology by identifying and dissecting a minimal enhancer regulating dlx2b expression during zebrafish tooth development, supported by promoter dissection, reporter assays, and genome-editing approaches. The work offers a resource and extends previous findings but has limited broader impact, with several conclusions about general cis-regulatory principles and functional consequences remaining only partially supported. Accordingly, the strength of evidence is at present incomplete, as additional functional validation would be needed to fully substantiate some of the claims.

   Reviewed by eLife

4. Continuous partitioning of neuronal variability

   This article has 3 authors:

   1. Anuththara Rupasinghe
   2. Adam S Charles
   3. Jonathan W Pillow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work of fundamental significance introduces a novel statistical model of spiking activity that incorporates continuous-time gain modulation. The authors provide exceptional evidence that the model outperforms earlier approaches and alternative candidates in capturing spiking responses across multiple visual areas in the macaque. Beyond its methodological contribution, the study offers new insights into how stimulus-driven variability and internally generated gain fluctuations evolve over time and between brain areas. The framework is likely to find broad application beyond the datasets examined here.

   Reviewed by eLife

5. Identity and functions of monoaminergic neurons in the predatory nematode Pristionchus pacificus reveal nervous system conservation and divergence

   This article has 15 authors:

   1. Curtis M Loer
   2. Hyunsoo Yim
   3. Luke T Geiger
   4. Yasmin H Ramadan
   5. Megan F Hampton
   6. Diana V Bernal
   7. Heather R Carstensen
   8. Jorge Morgan
   9. Laura Rivard
   10. Theresa Medina
   11. Steven J Cook
   12. Misako Okumura
   13. James Lightfoot
   14. Oliver Hobert
   15. Ray L Hong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable insights into cellular sites of monoamine production and presence in Pristionchus pacificus, providing a comparative reference for the detailed knowledge of C. elegans, as well as using this information to compare serotonergic anatomy in 22 nematode species. Functional assays support evolved differences in monoaminergic control over certain, but not all, tested behaviors. The evidence is convincing, combining careful genetic experiments and comparative analysis that are well aligned with the conclusions. The results will serve as a basis for (comparative) structural-functional studies of nematode behavior.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2024.04.02.587752

7. High performance sorting of motor unit action potentials with EMUsort

   This article has 10 authors:

   1. Sean O’Connell
   2. Jonathan A Michaels
   3. Runming Wang
   4. Sahit Mamidipaka
   5. Manikandan Venkatesh
   6. Nevin Aresh
   7. Marius Pachitariu
   8. J Andrew Pruszynski
   9. Samuel J Sober
   10. Chethan Pandarinath

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents a new method to identify the activity of single motor units from intramuscular EMG recordings. Validation against state-of-the-art techniques is limited to a small sample of simulated motor units; consequently, the evidence supporting the method's accuracy remains incomplete. The manuscript would be significantly strengthened by using more unbiased simulations for validation, validating the method with experimental datasets, comparing it against more recent techniques, and investigating how muscle physiology impacts accuracy.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.03.19.644130

9. Retrieval practice prevents stress-induced inference impairment by restoring rapid memory reactivation

   This article has 5 authors:

   1. Jinpeng Guo
   2. Ruixin Chen
   3. Qi Zhao
   4. Xiaojun Sun
   5. Wei Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on how retrieval practice protects memory inferences from stress via covert memory reactivation. Via two EEG experiments manipulating stress and retrieval practice, the authors provide solid evidence supporting the conclusion. This work will be of interest to cognitive and affective neuroscientists working on the intersection between memory and stress.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2025.10.13.682010