eLife

Latest preprint reviews

1. Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina

   This article has 9 authors:

   1. Sidney P Kuo
   2. Wan-Qing Yu
   3. Prerna Srivastava
   4. Haruhisa Okawa
   5. Luca Della Santina
   6. David M Berson
   7. Gautam B Awatramani
   8. Rachel OL Wong
   9. Fred Rieke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study shows that retinal bipolar cell subtype-specific differences in the size of synaptic ribbon-associated vesicle pools contribute to the transient versus sustained kinetics of the responses of retinal ganglion cells. The findings are important and the data is extensive and solid, however, there is also the possibility that glutamate release could be modulated by the kinetics of presynaptic inhibition at bipolar cell terminals and this may contribute to mediating the transient and/or sustained kinetics of glutamate release. This work will be of broad interest to researchers working on synaptic transmission, retinal signal processing, and sensory neurobiology.

   Reviewed by eLife

2. Brain-wide arousal signals are segregated from movement planning in the superior colliculus

   This article has 2 authors:

   1. Richard Johnston
   2. Matthew A Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding relating to how the state of arousal is represented within the superior colliculus, a principal visuo-oculomotor structure. The main conclusion that the representation of arousal is segregated, and thus does not directly influence motor output, is incompletely supported by the evidence and the work would be improved if additional analyses were performed to rule out alternative explanations. The work will be of interest to sensory, motor, and cognitive neuroscientists.

   Reviewed by eLife

3. Bridging verbal coordination and neural dynamics

   This article has 6 authors:

   1. Isaïh Schwab-Mohamed
   2. Manuel R Mercier
   3. Agnès Trébuchon
   4. Benjamin Morillon
   5. Leonardo Lancia
   6. Daniele Schön

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study aims to move beyond current experimental approaches in speech production by (1) investigating speech in the context of a fully interactive task and (2) employing advanced methodology to record intracranial brain activity. Together these allow for examination of the unfolding temporal dynamics of brain-behaviour relationships during interactive speech. While this approach makes the findings highly compelling, the data are currently deemed incomplete in that neural recordings were only analysed from the left hemisphere (due to insufficient clinical electrode implantation in the right), neglecting the contribution of the right hemisphere.

   Reviewed by eLife

4. Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina

   This article has 10 authors:

   1. Sören J Zapp
   2. Mohammad H Khani
   3. Helene M Schreyer
   4. Shashwat Sridhar
   5. Varsha Ramakrishna
   6. Steffen Krüppel
   7. Matthias Mietsch
   8. Dario A Protti
   9. Dimokratis Karamanlis
   10. Tim Gollisch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper introduces an efficient approach to identify subunits in the receptive fields of retinal ganglion cells. The general approach has been used in this application previously and this limits the conceptual advance of the paper. The improved speed is valuable, as it allows a more thorough exploration of the control parameters in this analysis and facilitates application to larger populations of cells. Validation of the approach is convincing. The paper would benefit from a more thorough exploration of the method and its limitations, or an extension of the new results about subunit populations.

   Reviewed by eLife

5. Near infrared radiation-driven oxygenic photosynthesis contributes substantially to primary production in biofilms harboring chlorophyll f-containing cyanobacteria

   This article has 4 authors:

   1. Maria Mosshammer
   2. Erik CL Trampe
   3. Niels-Ulrik Frigaard
   4. Michael Kühl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study investigates the contribution of far-red light photo-acclimated cyanobacteria to primary production in intertidal beachrock habitats. Though the study presents solid evidence, the text would benefit from an improved discussion section and some additional methodological details.

   Reviewed by eLife

6. Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

   This article has 13 authors:

   1. Yue Yang
   2. Bin Huang
   3. Yimeng Qin
   4. Danwei Wang
   5. Yinuo Jin
   6. Linmin Su
   7. Yi Pan
   8. Yanfeng Zhang
   9. Yumeng Shen
   10. Wenjun Hu
   11. Zhengyu Cao
   12. Liang Jin
   13. Fangfang Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study utilizes a comprehensive array of animal and cellular models, alongside various techniques, to elucidate the mechanism by which adipose tissue miR-802 contributes to inflammation and metabolic dysfunction in obesity. The data is solid, with clear, reproducible changes showing low variability among biological replicates and consistency across different models. However, some conclusions should be further substantiated with additional data to enhance the scope and strength of the manuscript.

   Reviewed by eLife

7. Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

   This article has 4 authors:

   1. Eleanor Martin
   2. Rossana Girardello
   3. Gunnar Dittmar
   4. Alexander Ludwig

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses convincing time-resolved proximity proteomics, validated with proximity ligation assays, to provide new insight into mechanical regulation of caveolin-1 complexes that form in migrating cells. Solid follow up experiments reveal a reciprocal relationship between mechanosensitive caveolae and RhoGTPase signalling in migrating cells, but evidence supporting a direct link between the newly identified factors with a specific caveolae subpopulation remains incomplete at this stage.

   Reviewed by eLife

8. Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity

   This article has 2 authors:

   1. Alexa Tompary
   2. Lila Davachi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study investigates how memory representations are transformed over time (24h period). The work advances our understanding of the neural processes supporting the behavioral integration of memories for distinct events that are never experienced together in time but are linked by shared predictive cues. Evidence supporting the claims is solid, and reporting of additional comparisons would have strengthened the study.

   Reviewed by eLife

9. Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

   This article has 6 authors:

   1. Mehul Vora
   2. Jonathan Dietz
   3. Zachary Wing
   4. Jun Liu
   5. Christopher Rongo
   6. Cathy Savage-Dunn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings that will allow for a better understanding of the targets of SMAD and Schnurri, transcription factors that act downstream in the BMP signalling pathway. The evidence presented in this manuscript is solid, but because the claims of a SMA-3/SMA-9 complex are not experimentally supported, they should be toned down. Revising the discussion to give a broader context of BMP-driven body size control would help the readers put this work in a larger context. This work will be of broad interest to colleagues studying BMP signalling across phyla.

   Reviewed by eLife

10. Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra

    This article has 17 authors:

    1. Namrata Bhattacharya
    2. Anja Rockstroh
    3. Sanket Suhas Deshpande
    4. Sam Koshy Thomas
    5. Anunay Yadav
    6. Chitrita Goswami
    7. Smriti Chawla
    8. Pierre Solomon
    9. Cynthia Fourgeux
    10. Gaurav Ahuja
    11. Brett G Hollier
    12. Himanshu Kumar
    13. Antoine Roquilly
    14. Jeremie Poschmann
    15. Melanie Lehman
    16. Colleen C Nelson
    17. Debarka Sengupta

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable study introduces SCellBOW, a novel tool leveraging natural language processing techniques to enhance cell clustering and infer survival risks from single-cell RNA sequencing data. The methodology and results are convincing, demonstrating superior clustering performance and the ability to assign risk scores to cancer cell clusters across multiple datasets. SCellBOW's unique approach promises significant advancements in understanding cancer cell heterogeneity and identifying aggressive cancer cell subgroups.

    Reviewed by eLife