eLife

Latest preprint reviews

1. Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases

   This article has 11 authors:

   1. Hanako Hagio
   2. Wataru Koyama
   3. Shiori Hosaka
   4. Aysenur Deniz Song
   5. Janchiv Narantsatsral
   6. Koji Matsuda
   7. Takashi Shimizu
   8. Shoko Hososhima
   9. Satoshi P Tsunoda
   10. Hideki Kandori
   11. Masahiko Hibi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a valuable resource for scientists who wish to manipulate second messengers in zebrafish using optogenetics. The authors provide solid evidence, based on behaviour, monitoring of heart beat and imaging, that several of the opsins tested can have an effect in larval fish. Opsins that lack an effect are also described. As the second messengers affected by the tools are found in multiple cell types, the results should be of interest of scientists working in a variety of areas.

   Reviewed by eLife

2. Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells

   This article has 11 authors:

   1. Hanako Hagio
   2. Wataru Koyama
   3. Shiori Hosaka
   4. Aysenur Deniz Song
   5. Janchiv Narantsatsral
   6. Koji Matsuda
   7. Tomohiro Sugihara
   8. Takashi Shimizu
   9. Mitsumasa Koyanagi
   10. Akihisa Terakita
   11. Masahiko Hibi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work provides a potentially useful resource for scientists who wish to use optogenetics to manipulate GPCR signalling in larval zebrafish. It compares the physiological effects of different vertebrate and invertebrate rhodopsins expressed in either reticulospinal neurons or cardiomyocytes. The evidence for light-induced effects on behavior (either tail bending or heart beating) is solid, although only limited cell types and conditions are tested.

   Reviewed by eLife

3. Dynamics of immune memory and learning in bacterial communities

   This article has 2 authors:

   1. Madeleine Bonsma-Fisher
   2. Sidhartha Goyal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important work, the authors develop a theory for the co-evolutionary dynamics of bacteria and phages, where the major evolutionary pressure comes from CRISPR-Cas adaptive immunity in bacteria. Through extensive stochastic numerical simulations and analytical calculations, the paper presents a compelling analysis of the emergent properties of immune interactions, in the regime of a single proto-spacer and a single spacer. Some of the trends highlighted by the model are recovered from experimental data. The main results concern how diversity in both phage and bacteria population are linked and are shaped by immunity, and should be of broad interest in immunology.

   Reviewed by eLife

4. Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests

   This article has 23 authors:

   1. Clement Karsenty
   2. Celine Guilbeau-Frugier
   3. Gaël Genet
   4. Marie-Helene Seguelas
   5. Philippe Alzieu
   6. Olivier Cazorla
   7. Alexandra Montagner
   8. Yuna Blum
   9. Caroline Dubroca
   10. Julile Maupoint
   11. Blandine Tramunt
   12. Marie Cauquil
   13. Thierry Sulpice
   14. Sylvain Richard
   15. Silvia Arcucci
   16. Remy Flores-Flores
   17. Nicolas Pataluch
   18. Romain Montoriol
   19. Pierre Sicard
   20. Antoine Deney
   21. Thierry Couffinhal
   22. Jean-Michel Senard
   23. Celine Galés

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable paper that relates the function of Ephrin-B1 to diastolic dysfunction via its actions on maturation of cardiomyocytes. The mechanisms of diastolic heart failure remain poorly understood, and this work contributes to advancing our understanding. The hypothesis is novel and the manuscript is fairly extensive and well-illustrated. The data, methods and analyses are presented to the community in a solid manner. The work represents an interesting insight into potential mechanisms of diastolic dysfunction and heart failure with preserved ejection fraction.

   Reviewed by eLife

5. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

   This article has 11 authors:

   1. Ryszard Stefan Gomolka
   2. Lauren M Hablitz
   3. Humberto Mestre
   4. Michael Giannetto
   5. Ting Du
   6. Natalie Linea Hauglund
   7. Lulu Xie
   8. Weiguo Peng
   9. Paula Melero Martinez
   10. Maiken Nedergaard
   11. Yuki Mori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript is of interest to neuroimaging scientists and neurophysiologists studying the glymphatic system. Using a multi-modal approach including magnetic resonance and histological methods, this work provides substantial data interrogating the effect of removing of aquaporin-4 (AQP4) from the mouse brain parenchyma on the structural morphology and interstitial fluid dynamics stagnation. In particular, the authors provide evidence that deletion of AQP4 in mice results in increased interstitial volume, likely due to increased resistance to parenchymal CSF efflux.

   Reviewed by eLife

6. Efficacy and safety of endocrine therapy after mastectomy in patients with hormone receptor positive breast ductal carcinoma in situ: Retrospective cohort study

   This article has 16 authors:

   1. Nan Niu
   2. Yinan Zhang
   3. Yang Bai
   4. Xin Wang
   5. Shunchao Yan
   6. Dong Song
   7. Hong Xu
   8. Tong Liu
   9. Bin Hua
   10. Yingchao Zhang
   11. Jinchi Liu
   12. Xinbo Qiao
   13. Jiaxiang Liu
   14. Xinyu Zheng
   15. Hongyi Cao
   16. Caigang Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study describes the effects of endocrine therapy in a large series of Chinese patients treated with mastectomy (both efficacy and side effects). Whilst there are some caveats regarding the methodology (retrospective, small numbers of events, and some potential methodological bias in data collection) this is a solid piece of work and with further, ideally prospective data collection, has the potential to improve the management of patients with DCIS.

   Reviewed by eLife

7. Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

   This article has 6 authors:

   1. Angela M Phillips
   2. Daniel P Maurer
   3. Caelan Brooks
   4. Thomas Dupic
   5. Aaron G Schmidt
   6. Michael M Desai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, authors convincingly show that epistasis between mutations plays an important role in the evolution of broadly neutralizing influenza antibodies. Although the data are convincing, several parts of the manuscript require more accurate description.

   Reviewed by eLife

8. Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

   This article has 9 authors:

   1. Mi Huang
   2. Daniel Coral
   3. Hamidreza Ardalani
   4. Peter Spegel
   5. Alham Saadat
   6. Melina Claussnitzer
   7. Hindrik Mulder
   8. Paul W Franks
   9. Sebastian Kalamajski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study provides a fundamental framework for linking human genome variation to targetable mechanisms of disease. The authors provide compelling evidence that a strong candidate locus associates with body weight in humans acts through adipocyte MTIF3. Thus, the generalized approaches taken in this study have the potential to inform genetic association studies in general and lay a foundation for future functional genomics studies.

   Reviewed by eLife

9. Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

   This article has 14 authors:

   1. Camryn Pajon
   2. Marla C Fortoul
   3. Gabriela Diaz-Tang
   4. Estefania Marin Meneses
   5. Ariane R Kalifa
   6. Elinor Sevy
   7. Taniya Mariah
   8. Brandon Toscan
   9. Maili Marcelin
   10. Daniella M Hernandez
   11. Melissa M Marzouk
   12. Allison J Lopatkin
   13. Omar Tonsi Eldakar
   14. Robert P Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How the pathogens Pseudomonas aeruginosa and Staphylococcus aureus compete and co-occur within opportunistic infections is a topic of broad significance, but the major drivers of these interactions remain unclear. Here the authors defined parameters that predict the coexistence of these microbes using their absolute growth in certain nutritional conditions, leading to questions about how other nutrients lead to the dominance of one or the other during infections. Within a confined context, this valuable study provides solid support for a novel framework in which to evaluate this clinically important species interaction.

   Reviewed by eLife

10. Embryo-derive TNF promotes decidualization via fibroblast activation

    This article has 10 authors:

    1. Si-Ting Chen
    2. Wen-Wen Shi
    3. Yu-Qian Lin
    4. Zhen-Shan Yang
    5. Ying Wang
    6. Meng-Yuan Li
    7. Yue Li
    8. Ai-Xia Liu
    9. Yali Hu
    10. Zeng-Ming Yang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The authors provide novel evidence for a connection between fibroblast activation and eutherian stromal decidualization. This important work substantially advances our understanding of decidua biology and its contribution to pregnancy. The authors are using solid evidence to support the findings. The methodology includes in vivo mouse and human stroma cells is broadly supports the claims with only minor weaknesses.

    Reviewed by eLife