eLife

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1. GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar–pillar morphology

   This article has 6 authors:

   1. Mark A Rutherford
   2. Atri Bhattacharyya
   3. Maolei Xiao
   4. Hou-Ming Cai
   5. Indra Pal
   6. Maria Eulalia Rubio

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Hearing is mediated by hair cells in the cochlea, which synapse onto the primary dendrites of the auditory nerve. This study shows how deletion of a postsynaptic glutamate receptor subtype strongly influences inner hair cell-spiral ganglion cell synapse formation. Thus pre- and post-synaptic changes are dynamically intertwined, providing insights into how pathological outcomes arise from synaptic perturbations.

   Reviewed by eLife

2. Geometric control of myosin II orientation during axis elongation

   This article has 5 authors:

   1. Matthew F Lefebvre
   2. Nikolas H Claussen
   3. Noah P Mitchell
   4. Hannah J Gustafson
   5. Sebastian J Streichan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper should be of broad interest to developmental biologists who seek to understand spatiotemporal control of myosin-based force generation during tissue morphogenesis during early development. The central conclusions are well-grounded in rigorous quantitative data analysis and modeling. The results challenge current views of how gene expression patterns control myosin II anisotropies and provide new testable hypotheses on the role and importance of tissue geometry.

   Reviewed by eLife

3. Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

   This article has 17 authors:

   1. Jacob M Winter
   2. Heidi L Fresenius
   3. Corey N Cunningham
   4. Peng Wei
   5. Heather R Keys
   6. Jordan Berg
   7. Alex Bott
   8. Tarun Yadav
   9. Jeremy Ryan
   10. Deepika Sirohi
   11. Sheryl R Tripp
   12. Paige Barta
   13. Neeraj Agarwal
   14. Anthony Letai
   15. David M Sabatini
   16. Matthew L Wohlever
   17. Jared Rutter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors identify co-deletion of the mitochondrial AAA+ ATPase ATAD1 with the tumor suppressor PTEN as a factor modifying cancer prognosis, based on a new mechanism of increasing sensitivity to proteotoxic stress induced by proteasome inhibition. The authors also identify the mitochondrial E3 ubiquitin ligase MARCH5 as a gene whose deletion is synthetically lethal with ATAD1. These findings suggest that the use of proteasome-targeting agents may be useful in patients with tumors dually deleted for ATAD1 and PTEN. The study is based on convincing evidence, and makes an innovative contribution to the understanding of the biology of tumors with 10q23 deletions.

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4. Acetylation of a fungal effector that translocates host PR1 facilitates virulence

   This article has 11 authors:

   1. Jingtao Li
   2. Xiaoying Ma
   3. Chenyang Wang
   4. Sihui Liu
   5. Gang Yu
   6. Mingming Gao
   7. Hengwei Qian
   8. Mengjie Liu
   9. Ben F Luisi
   10. Dean W Gabriel
   11. Wenxing Liang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors provided strong evidence that the Fusarium oxysporum effector protein FolSpv1 enhances virulence by targeting tomato SlPR1 and preventing the generation of the SlPR1-derived phytocytokine CAPE1, which otherwise positively regulates disease resistance in tomato plants. Strikingly, they show that FolSpv1 translocates SlPR1 from the apoplast back into the nucleus of tomato cell, suggesting a previously unknown mechanism employed by pathogenic microbes.

   Reviewed by eLife

5. The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

   This article has 6 authors:

   1. Andrea Bonicelli
   2. Hayley L Mickleburgh
   3. Alberto Chighine
   4. Emanuela Locci
   5. Daniel J Wescott
   6. Noemi Procopio

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This well-presented and sophisticated study provides significant proof-of-concept for the application of the ForensOMICS approach as a new pathway for forensic taphonomy with great promise to advance future research. The solid foundation of the research combining metabolomics, proteomics, and lipidomics is considered very exciting, strong, and expands the boundaries of forensics research.

   Reviewed by eLife

6. Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

   This article has 5 authors:

   1. Amy E Spens
   2. Nicholas A Sutliff
   3. Sean R Bennett
   4. Amy E Campbell
   5. Stephen J Tapscott

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The transcription factor DUX4 is emerging as a key molecule in early mammalian development and in diverse pathologies including muscular dystrophy and solid tumors. While DUX4 has been linked to immune evasion, the mechanisms have not been delineated. In this study, the authors demonstrate that DUX4 functions as a negative regulator of interferon signaling by inhibiting STAT1, thereby suppressing interferon-stimulated gene induction. These studies provide a critical mechanistic link between DUX4 expression and the modulation of immune signaling pathways.

   Reviewed by eLife

7. Human endogenous oxytocin and its neural correlates show adaptive responses to social touch based on recent social context

   This article has 6 authors:

   1. Linda Handlin
   2. Giovanni Novembre
   3. Helene Lindholm
   4. Robin Kämpe
   5. Elisabeth Paul
   6. India Morrison

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript contains fundamental work on hormonal and neurobiological processing of social experience in humans. It sheds compelling new light on potential mechanisms underlying how humans place social experiences in context, demonstrating how oxytocin and cortisol might interact to modulate higher-level processing and contextualizing of familiar vs. stranger encounters.

   Reviewed by eLife

8. The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

   This article has 17 authors:

   1. Christoph Wiest
   2. Flavie Torrecillos
   3. Alek Pogosyan
   4. Manuel Bange
   5. Muthuraman Muthuraman
   6. Sergiu Groppa
   7. Natasha Hulse
   8. Harutomo Hasegawa
   9. Keyoumars Ashkan
   10. Fahd Baig
   11. Francesca Morgante
   12. Erlick A Pereira
   13. Nicolas Mallet
   14. Peter J Magill
   15. Peter Brown
   16. Andrew Sharott
   17. Huiling Tan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important manuscript the authors use a powerful cross-specifies approach and cutting-edge experimental methods to examine possible shifts in the excitatory and inhibitory balance in both an animal model of Parkinsonism and in human patients with Parkinson's disease. Their solid findings support such a shift, wherein untreated Parkinson's disease is characterized by excessive activity in the subthalamic nucleus. While a strong paper, there are concerns with some of the methodological choices and their implications.

   Reviewed by eLife

9. Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning

   This article has 10 authors:

   1. Hélène Vitet
   2. Julie Bruyère
   3. Hao Xu
   4. Claire Séris
   5. Jacques Brocard
   6. Yah-Sé Abada
   7. Benoît Delatour
   8. Chiara Scaramuzzino
   9. Laurent Venance
   10. Frédéric Saudou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors examine transport and synaptic activity in the corticostriatal circuit in both microfluidic devices and in mice. They convincingly show that the Huntingtin protein regulates the anterograde transport of synaptic vesicle precursors in coordination with the molecular motor KIF1A. Activated Huntingtin recruits KIF1A, accelerates synaptic vesicle precursor's transport, modifies synaptic transmission and motor skill learning in mice. This work sheds new light on the role of axonal transport in synaptic function under physiological and pathological conditions related to Huntington's disease.

   Reviewed by eLife

10. A Drosophila glial cell atlas reveals a mismatch between detectable transcriptional diversity and morphological diversity

    This article has 8 authors:

    1. Inês Lago-Baldaia
    2. Maia Cooper
    3. Austin Seroka
    4. Chintan Trivedi
    5. Gareth T. Powell
    6. Stephen Wilson
    7. Sarah D. Ackerman
    8. Vilaiwan M. Fernandes

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents an atlas of glial cell morphology in Drosophila, from distinct locations at different periods of life. The authors integrate morphological information with the transcriptomic signatures of those cells and find that morphological diversity among glial cells of a given class is not a strong predictor of transcriptional identity. The study is of great value as connecting morphology with scRNA sequencing analysis is rarely done and is a necessary step for understanding the underlying biology of these cells. While the weak morphotype-transcriptomic link in many cases may be due to low sequencing resolution, nonetheless, the data are of very high quality and the study will be a very useful resource for the glial biology field.

    Reviewed by eLife