eLife

Latest preprint reviews

1. Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

   This article has 10 authors:

   1. Zoltán Szadai
   2. Hyun-Jae Pi
   3. Quentin Chevy
   4. Katalin Ócsai
   5. Dinu F Albeanu
   6. Balázs Chiovini
   7. Gergely Szalay
   8. Gergely Katona
   9. Adam Kepecs
   10. Balázs Rózsa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of potential interest to neuroscientists expert in cortical circuitry and behavioral role of neuron types. The imaging technique used permitted to detect a specific group of cortical neurons known as vasoactive intestinal peptide (VIP)-expressing interneurons from several cortical regions with high temporal resolution. The main message conveyed by this manuscript is that many VIP-expressing interneurons respond to reward and punishment but also show regional differences. The conclusions drawn are generally supported by the data, but some claims and interpretations require further attention and clarification.

   Reviewed by eLife

2. Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

   This article has 14 authors:

   1. Muniesh Muthaiyan Shanmugam
   2. Jyotiska Chaudhuri
   3. Durai Sellegounder
   4. Amit Kumar Sahu
   5. Sanjib Guha
   6. Manish Chamoli
   7. Brian Hodge
   8. Neelanjan Bose
   9. Charis Amber
   10. Dominique O Farrera
   11. Gordon Lithgow
   12. Richmond Sarpong
   13. James J Galligan
   14. Pankaj Kapahi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work, which examines how Advanced Glycation End-products (AGEs), commonly found in processed and other cooked foods, affect eating behavior and signaling in the nematode C. elegans, is in a fundamentally important area of research with clear translational potential for humans. Some aspects of the manuscript are compelling, including the well-characterized assays on food intake, while other aspects are still incomplete, such as the mechanistic work on the neural network responsible for the response to AGEs.

   Reviewed by eLife

3. A fear conditioned cue orchestrates a suite of behaviors in rats

   This article has 8 authors:

   1. Amanda Chu
   2. Nicholas T Gordon
   3. Aleah M DuBois
   4. Christa B Michel
   5. Katherine E Hanrahan
   6. David C Williams
   7. Stefano Anzellotti
   8. Michael A McDannald

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important and timely characterization of a diversity of behaviors male and female rats exhibit during the acquisition of Pavlovian fear conditioning in a conditioned suppression procedure. The data are compelling and provide an exhaustive analysis of behavior in a complex associative learning paradigm that blends aversive Pavlovian and appetitive instrumental elements. The generalizability of these findings to other paradigms could be enhanced, however, with the inclusion of tests of cue responses in a neutral environment. These findings are likely to be of interest to those who study fear conditioning and associative learning more broadly in rodents.

   Reviewed by eLife

4. Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations

   This article has 129 authors:

   1. Katharine Sherratt
   2. Hugo Gruson
   3. Rok Grah
   4. Helen Johnson
   5. Rene Niehus
   6. Bastian Prasse
   7. Frank Sandmann
   8. Jannik Deuschel
   9. Daniel Wolffram
   10. Sam Abbott
   11. Alexander Ullrich
   12. Graham Gibson
   13. Evan L Ray
   14. Nicholas G Reich
   15. Daniel Sheldon
   16. Yijin Wang
   17. Nutcha Wattanachit
   18. Lijing Wang
   19. Jan Trnka
   20. Guillaume Obozinski
   21. Tao Sun
   22. Dorina Thanou
   23. Loic Pottier
   24. Ekaterina Krymova
   25. Jan H Meinke
   26. Maria Vittoria Barbarossa
   27. Neele Leithauser
   28. Jan Mohring
   29. Johanna Schneider
   30. Jaroslaw Wlazlo
   31. Jan Fuhrmann
   32. Berit Lange
   33. Isti Rodiah
   34. Prasith Baccam
   35. Heidi Gurung
   36. Steven Stage
   37. Bradley Suchoski
   38. Jozef Budzinski
   39. Robert Walraven
   40. Inmaculada Villanueva
   41. Vit Tucek
   42. Martin Smid
   43. Milan Zajicek
   44. Cesar Perez Alvarez
   45. Borja Reina
   46. Nikos I Bosse
   47. Sophie R Meakin
   48. Lauren Castro
   49. Geoffrey Fairchild
   50. Isaac Michaud
   51. Dave Osthus
   52. Pierfrancesco Alaimo Di Loro
   53. Antonello Maruotti
   54. Veronika Eclerova
   55. Andrea Kraus
   56. David Kraus
   57. Lenka Pribylova
   58. Bertsimas Dimitris
   59. Michael Lingzhi Li
   60. Soni Saksham
   61. Jonas Dehning
   62. Sebastian Mohr
   63. Viola Priesemann
   64. Grzegorz Redlarski
   65. Benjamin Bejar
   66. Giovanni Ardenghi
   67. Nicola Parolini
   68. Giovanni Ziarelli
   69. Wolfgang Bock
   70. Stefan Heyder
   71. Thomas Hotz
   72. David E Singh
   73. Miguel Guzman-Merino
   74. Jose L Aznarte
   75. David Morina
   76. Sergio Alonso
   77. Enric Alvarez
   78. Daniel Lopez
   79. Clara Prats
   80. Jan Pablo Burgard
   81. Arne Rodloff
   82. Tom Zimmermann
   83. Alexander Kuhlmann
   84. Janez Zibert
   85. Fulvia Pennoni
   86. Fabio Divino
   87. Marti Catala
   88. Gianfranco Lovison
   89. Paolo Giudici
   90. Barbara Tarantino
   91. Francesco Bartolucci
   92. Giovanna Jona Lasinio
   93. Marco Mingione
   94. Alessio Farcomeni
   95. Ajitesh Srivastava
   96. Pablo Montero-Manso
   97. Aniruddha Adiga
   98. Benjamin Hurt
   99. Bryan Lewis
   100. Madhav Marathe
   101. Przemyslaw Porebski
   102. Srinivasan Venkatramanan
   103. Rafal P Bartczuk
   104. Filip Dreger
   105. Anna Gambin
   106. Krzysztof Gogolewski
   107. Magdalena Gruziel-Slomka
   108. Bartosz Krupa
   109. Antoni Moszyński
   110. Karol Niedzielewski
   111. Jedrzej Nowosielski
   112. Maciej Radwan
   113. Franciszek Rakowski
   114. Marcin Semeniuk
   115. Ewa Szczurek
   116. Jakub Zielinski
   117. Jan Kisielewski
   118. Barbara Pabjan
   119. Kirsten Holger
   120. Yuri Kheifetz
   121. Markus Scholz
   122. Biecek Przemyslaw
   123. Marcin Bodych
   124. Maciej Filinski
   125. Radoslaw Idzikowski
   126. Tyll Krueger
   127. Tomasz Ozanski
   128. Johannes Bracher
   129. Sebastian Funk

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This large-scale collaborative study is a timely contribution that will be of interest to researchers working in the fields of infectious disease forecasting and epidemic control. This paper provides a comprehensive evaluation of the predictive skills of real-time COVID-19 forecasting models in Europe. The conclusions of the paper are well supported by the data and are consistent with findings from studies in other countries.

   Reviewed by eLife

5. Deep learning-driven insights into super protein complexes for outer membrane protein biogenesis in bacteria

   This article has 3 authors:

   1. Mu Gao
   2. Davi Nakajima An
   3. Jeffrey Skolnick

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable contribution, the authors apply an artificial intelligence method to predict the three-dimensional structure of complexes of outer membrane proteins of the Gram-negative bacterium E. coli. Some of the cases presented are compelling, as they explain previously published biochemical data and/or reproduce existing structural data.

   Reviewed by eLife

6. Mice and primates use distinct strategies for visual segmentation

   This article has 8 authors:

   1. Francisco J Luongo
   2. Lu Liu
   3. Chun Lum Andy Ho
   4. Janis K Hesse
   5. Joseph B Wekselblatt
   6. Frank F Lanfranchi
   7. Daniel Huber
   8. Doris Y Tsao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Primates perceive and detect stimuli differently depending on the stimulus context in which they are embedded, and have a remarkable ability to understand the way in which objects and parts of objects are embedded in natural scenes (scene segmentation). An example of this is figure-ground segmentation, a well documented phenomenon resulting in a "pop-out" of a figure region and corresponding enhanced neural firing rates in visual areas. It is unknown whether mice show similar behavioral and neural signatures as primates. The present study suggests that mice show different segmentation behavior than primates, lacking texture-invariant segmentation of figures and corresponding neural correlates. This reveals a fundamental difference between primates and mice important for researchers working on these species and researchers studying scene segmentation. The findings are further interpreted in terms of neural network architectures (feedforward networks) and are relevant for this field too.

   Reviewed by eLife

7. Fast rule switching and slow rule updating in a perceptual categorization task

   This article has 5 authors:

   1. Flora Bouchacourt
   2. Sina Tafazoli
   3. Marcelo G Mattar
   4. Timothy J Buschman
   5. Nathaniel D Daw

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study modeled monkeys' behavior in a stimulus-response rule-learning task to show that animals can adopt mixed strategies involving inference for learning latent states and incremental updating for learning action-outcome associations. The task is cleverly designed, the modeling is rigorous, and importantly there are clear distinctions in the behavior generated by different models, which makes the authors' conclusions convincing. The study makes a strong contribution overall, however, there were aspects of the design that were unclear and some alternative accounts that were not considered.

   Reviewed by eLife

8. Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

   This article has 12 authors:

   1. Jazlyn P Borges
   2. Ragnhild SR Sætra
   3. Allen Volchuk
   4. Marit Bugge
   5. Pascal Devant
   6. Bjørnar Sporsheim
   7. Bridget R Kilburn
   8. Charles L Evavold
   9. Jonathan C Kagan
   10. Neil M Goldenberg
   11. Trude Helen Flo
   12. Benjamin Ethan Steinberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     It's been widely known that the amino acid Glycine can work as a cytoprotectant and inhibit pyroptosis-associated plasma membrane rupture. However, a long-standing question has been: how does Glycine cytoprotection work? The authors observed that Glycine treatment phenocopied deficiency of NINJ1 (a recently reported cell surface molecule critical for plasma membrane rupture), and can inhibit aggregation of NINJ1. Understanding the intrinsic mechanism by which Glycine affects NINJ1 could provide a significant advance in the cell death field.

   Reviewed by eLife

9. Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality

   This article has 9 authors:

   1. Brian Kim
   2. Seth Haney
   3. Ana P Milan
   4. Shruti Joshi
   5. Zane Aldworth
   6. Nikolai Rulkov
   7. Alexander T Kim
   8. Maxim Bazhenov
   9. Mark A Stopfer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study by Kim et al. combines extracellular recordings from olfactory sensory neurons (OSNs) in locusts with computational modelling approaches to investigate the dynamics of odour responses. The authors demonstrate that OSN responses can be grouped into four distinct response motifs, with OSNs showing different motifs in an odour-dependent manner. Using computational modelling the authors provide some evidence that these diverse response motifs expand the coding space and could facilitate odour discrimination and navigation. This study can be of high relevance to both experimental and theoretical neuroscientists investigating odour coding and odour-driven behaviours such as navigation. In its present form, while the experimental data and analysis are of the highest quality, the modelling part needs to be expanded to fully support the experimental measurements.

   Reviewed by eLife

10. Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

    This article has 14 authors:

    1. Samantha C Schwager
    2. Katherine M Young
    3. Lauren A Hapach
    4. Caroline M Carlson
    5. Jenna A Mosier
    6. Tanner J McArdle
    7. Wenjun Wang
    8. Curtis Schunk
    9. Anissa L Jayathilake
    10. Madison E Bates
    11. Francois Bordeleau
    12. Marc A Antonyak
    13. Richard A Cerione
    14. Cynthia A Reinhart-King

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The interesting manuscript shows that breast cancer cells that are poorly migratory in culture can be more metastatic in mice. This is due, at least in part, to the secretion of extracellular vesicles containing the the crosslinking enzyme Transglutaminase-2, which can activate fibroblasts in the tumours. These fibroblasts can then promote metastatic phenotypes. This study demonstrates how cancer cells can manipulate the cells around them in order to disseminate.

    Reviewed by eLife