eLife

Latest preprint reviews

1. Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

   This article has 8 authors:

   1. Yi Fan
   2. Ping Lyu
   3. Ruiye Bi
   4. Chen Cui
   5. Ruoshi Xu
   6. Clifford J Rosen
   7. Quan Yuan
   8. Chenchen Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important project, the authors used single-cell RNA-sequencing (scRNA-Seq) technology to profile the transcriptome of alveolar bone marrow single cells and demonstrated the protective role of mesenchymal stem cells (MSCs) during apical periodontitis. With comprehensive data, the authors identified new inflammatory biomarkers associated with the pathogenesis of oral inflammatory diseases. Their study suggests that certain MSC subsets may have a potential role in healing bone lesions.

   Reviewed by eLife

2. MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

   This article has 14 authors:

   1. Greta Rossi
   2. Gabriele Ordazzo
   3. Niccolò N Vanni
   4. Valerio Castoldi
   5. Angelo Iannielli
   6. Dario Di Silvestre
   7. Edoardo Bellini
   8. Letizia Bernardo
   9. Serena G Giannelli
   10. Mirko Luoni
   11. Sharon Muggeo
   12. Letizia Leocani
   13. PierLuigi Mauri
   14. Vania Broccoli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The primary goal of this paper is to characterize retinal dysfunction and retinal ganglion cell degeneration in the Wfs1exon8del murine model of Wolfram Syndrome 1. The study provides fundamental insight into the timelines of degeneration as well as valuable transcriptomic and proteomic datasets. The methodologies performed are generally rigorous and the conclusions reached are mostly well supported by the data, however, the interrogation of the mechanism is largely circumstantial and the relevance to disease is primarily speculative. The results of this study are highly relevant for molecular mechanisms in Wolfram Syndrome 1 and are of potential interest to scientists interested in oligodendrocyte and neuron communication.

   Reviewed by eLife

3. Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

   This article has 14 authors:

   1. Flora Mikaeloff
   2. Marco Gelpi
   3. Rui Benfeitas
   4. Andreas D Knudsen
   5. Beate Vestad
   6. Julie Høgh
   7. Johannes R Hov
   8. Thomas Benfield
   9. Daniel Murray
   10. Christian G Giske
   11. Adil Mardinoglu
   12. Marius Trøseid
   13. Susanne D Nielsen
   14. Ujjwal Neogi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study systematically integrates multi-omics data to identify the metabolic at-risk profiles within people living with HIV on antiretroviral therapy and presents findings that have focused importance and scope. The methods, data, and analyses as described now only partially support the primary claims.

   Reviewed by eLife

4. Iron status influences mitochondrial disease progression in Complex I-deficient mice

   This article has 13 authors:

   1. CJ Kelly
   2. Reid K Couch
   3. Vivian T Ha
   4. Camille M Bodart
   5. Judy Wu
   6. Sydney Huff
   7. Nicole T Herrel
   8. Hyunsung D Kim
   9. Azaad O Zimmermann
   10. Jessica Shattuck
   11. Yu-Chen Pan
   12. Matt Kaeberlein
   13. Anthony S Grillo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript starts from the hypothesis that a model of mitochondrial disease, the NDUFS4 knockout mouse, causes iron dysregulation, and that iron status may modify the neurological phenotypes that result in the mouse. This study has the potential to inform how body iron homeostasis can modify neurological phenotypes caused by mitochondrial disease. This study will be of interest to a broad audience of neuroscientists, particularly those with an interest in mitochondrial diseases.

   Reviewed by eLife

5. Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons

   This article has 12 authors:

   1. Kai Li
   2. Yuma Tsukasa
   3. Misato Kurio
   4. Kaho Maeta
   5. Akimitsu Tsumadori
   6. Shumpei Baba
   7. Risa Nishimura
   8. Akira Murakami
   9. Koun Onodera
   10. Takako Morimoto
   11. Tadashi Uemura
   12. Tadao Usui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents valuable findings on a gene called bero that affects the way larval Drosophila respond to nociceptive stimuli. This discovery is followed-up by the identification of neurons in which bero function is relevant for the modulation of nociceptive behavior, and by the additional identification of likely signaling molecules for conferring such modulation. The work will be of interest to neurobiologists working on genes, neural circuits, and behavior. While both interesting and methodologically elegant and diverse, important genetic controls for leaky expression of transgenes seem to be missing, as are alternative scenarios for results that, as the authors acknowledge, are unexpected or seemingly contradictory.

   Reviewed by eLife

6. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions

   This article has 10 authors:

   1. Uri Seroussi
   2. Andrew Lugowski
   3. Lina Wadi
   4. Robert X Lao
   5. Alexandra R Willis
   6. Winnie Zhao
   7. Adam E Sundby
   8. Amanda G Charlesworth
   9. Aaron W Reinke
   10. Julie M Claycomb

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This impressive study presents the most comprehensive analysis of the Argonautes, their small RNA partners, their targets, and their biological functions in any species to date. The work provides new insights into Argonaute-based pathways, it includes extensive validation of existing models, and describes overall a treasure-trove of reagents and datasets for future exploration of the vast Argonaute world in C. elegans.

   Reviewed by eLife

7. Echolocating bats prefer a high risk-high gain foraging strategy to increase prey profitability

   This article has 7 authors:

   1. Laura Stidsholt
   2. Antoniya Hubancheva
   3. Stefan Greif
   4. Holger R Goerlitz
   5. Mark Johnson
   6. Yossi Yovel
   7. Peter T Madsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important findings on the hunting strategies and energy intake of a bat in the wild. It combines several methods (biologging, captive experiment, and DNA metabarcoding) to provide convincing evidence for the claims. While relevant for researchers in the broad field of animal ecology, in its the current form, the significance of the results may be hard to appreciate for a general audience.

   Reviewed by eLife

8. MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism

   This article has 8 authors:

   1. Tsz Long Chu
   2. Peikai Chen
   3. Anna Xiaodan Yu
   4. Mingpeng Kong
   5. Zhijia Tan
   6. Kwok Yeung Tsang
   7. Zhongjun Zhou
   8. Kathryn Song Eng Cheah

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, the authors presented the novel findings that PTH signaling plays a significant role in bone formation in hypertrophic chondrocyte (HC)-derived osteoblasts and MMP14 cleaves PTH1R and inhibits PTH signaling. These studies significantly contribute to our understanding of molecular mechanisms of postnatal bone formation and adult bone remodeling, especially the HC cells in this process. The study was well-designed and well-conducted. The data in this study are convincing and support the conclusion made by the authors.

   Reviewed by eLife

9. A task-general connectivity model reveals variation in convergence of cortical inputs to functional regions of the cerebellum

   This article has 4 authors:

   1. Maedbh King
   2. Ladan Shahshahani
   3. Richard B Ivry
   4. Jörn Diedrichsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper should be a high priority for neuroscientists interested in the role of connectivity in generating cognitive functions, especially with respect to the cerebellum (which has more neurons than any other part of the human brain). This study makes a compelling case for convergent connectivity from cortex to cerebellum supporting a variety of cognitive functions in the cerebellum. However, insufficient details were provided for proper evaluation of claims, and some of the claims (such as directionality of cortico-cerebellar inferences) may not be supported by the analyses.

   Reviewed by eLife

10. Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

    This article has 13 authors:

    1. Jean-Philippe Defour
    2. Emilie Leroy
    3. Sharmila Dass
    4. Thomas Balligand
    5. Gabriel Levy
    6. Ian C Brett
    7. Nicolas Papadopoulos
    8. Céline Mouton
    9. Lidvine Genet
    10. Christian Pecquet
    11. Judith Staerk
    12. Steven O Smith
    13. Stefan N Constantinescu

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This very well-written paper advances our understanding of the mechanism of activation of the thrombopoietin receptor (TpoR), a very important cytokine receptor that regulates megakaryocyte differentiation and platelet production. The authors supply an elegant combination of NMR and cell biology experiments to support their conclusions and the data are of high quality.

    Reviewed by eLife