eLife

Latest preprint reviews

1. Structures of ferroportin in complex with its specific inhibitor vamifeport

   This article has 10 authors:

   1. Elena Farah Lehmann
   2. Márton Liziczai
   3. Katarzyna Drożdżyk
   4. Patrick Altermatt
   5. Cassiano Langini
   6. Vania Manolova
   7. Hanna Sundstrom
   8. Franz Dürrenberger
   9. Raimund Dutzler
   10. Cristina Manatschal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports cryo-EM structures of human ferroportin (FPN), a protein essential for iron transport in humans. This manuscript will be of interest to researchers studying membrane transport mechanisms as well as to those interested in drug design. The structures detail interactions between FPN and the small-molecule inhibitor vamifeport, which is currently in clinical trials for sickle cell disease, and ta new (occluded) protein conformation that is stabilized by a sybody (a nanobody selected from a synthetic library) is identified. Evidence for the mechanism of inhibition by vamifeport is convincing, but evidence for the physiological relevance of the occluded conformation is still incomplete.

   Reviewed by eLife

2. Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1

   This article has 5 authors:

   1. Brianna Vandrey
   2. Jack Armstrong
   3. Christina M Brown
   4. Derek LF Garden
   5. Matthew F Nolan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work reveals a novel direct projection from the lateral entorhinal cortex to the medial entorhinal cortex. Using multiple techniques, the authors provide compelling evidence that fan cells from the lateral entorhinal cortex project to superficial neurons in the medial entorhinal cortex. This newly identified connection may support the combination of spatial inputs with sensory or high-order signals, providing novel insight into potentially how the 'what' (lateral entorhinal cortex) and 'where' (medial entorhinal cortex) features of memory are incorporated.

   Reviewed by eLife

3. Drosophila SUMM4 complex couples insulator function and DNA replication control

   This article has 10 authors:

   1. Evgeniya N Andreyeva
   2. Alexander V Emelyanov
   3. Markus Nevil
   4. Lu Sun
   5. Elena Vershilova
   6. Christina A Hill
   7. Michael-C Keogh
   8. Robert J Duronio
   9. Arthur I Skoultchi
   10. Dmitry V Fyodorov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of interest to those studying DNA replication in the context of chromatin and development. This important study uncovers a new interaction partner for the chromatin protein SuUR and tries to understand how this complex (SUMM4) functions to control under-replication in polytene chromosomes. While the experiments are of high quality and carefully controlled, the data currently do not fully support all the conclusions, particularly as they relate to conclusions about DNA replication timing.

   Reviewed by eLife

4. Generating colorblind-friendly scatter plots for single-cell data

   This article has 3 authors:

   1. Tejas Guha
   2. Elana J Fertig
   3. Atul Deshpande

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript is extremely useful for describing an R package that provides a valuable pattern and overlay framework for producing colorblind-friendly scatter plots for the field. The utility of this tool for making plots more accessible was demonstrated compellingly. This work will be of broad interest to many biomedical scientists, especially to viewers with color-vision deficiency.

   Reviewed by eLife

5. The layered costs and benefits of translational redundancy

   This article has 4 authors:

   1. Parth K Raval
   2. Wing Yui Ngan
   3. Jenna Gallie
   4. Deepa Agashe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors investigate the cost and benefits of maintaining seemingly redundant multiple copies of the translation machinery components. The authors demonstrate that while redundant multiple copies are beneficial in a nutrient-rich environment, maintaining these extra copies is costly and deleterious in a nutrient-poor environment. This explains why copy numbers of translation machinery genes are under selection according to the environmental niche an organism occupies. The work is very important and the findings exciting and supported by compelling evidence. In particular, the fitness gain upon deletion of translation genes in poor conditions is an insightful observation.

   Reviewed by eLife

6. Nucleotide-level linkage of transcriptional elongation and polyadenylation

   This article has 6 authors:

   1. Joseph V Geisberg
   2. Zarmik Moqtaderi
   3. Nova Fong
   4. Benjamin Erickson
   5. David L Bentley
   6. Kevin Struhl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Giesberg and colleagues provide evidence both in yeast and human cells that fast elongation speeds of RNA polymerases result in a "downstream-shifted" poly(A) profile while the opposite is true for slower speeds of elongating polymerases. GC content of sequences downstream of poly(A) clusters influences the cluster profiles by affecting elongation and thus allowing more time for the 3'-cleavage complex to find the poly(A) site and form the transcript terminus. Although the findings presented in this manuscript are not surprising, they are new and contribute a missing piece to our knowledge of how the transcription machinery determines which poly(A) site to utilize at the end of genes.

   Reviewed by eLife

7. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function

   This article has 13 authors:

   1. Huanqing Gao
   2. Yiming Zhong
   3. Liang Zhou
   4. Sixiong Lin
   5. Xiaoting Hou
   6. Zhen Ding
   7. Yan Li
   8. Qing Yao
   9. Huiling Cao
   10. Xuenong Zou
   11. Di Chen
   12. Xiaochun Bai
   13. Guozhi Xiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     As shown by the authors, the focal adhesion protein, kindlin-2, plays an essential role in liver development in that its genetic inactivation leads to severe fibrosis and death in young mice. This lethality is attributed to increased liver inflammation and cell death. This work will be of interest to readers studying mechanisms of liver development and pathological fibrosis.

   Reviewed by eLife

8. Quantifying decision-making in dynamic, continuously evolving environments

   This article has 5 authors:

   1. Maria Ruesseler
   2. Lilian Aline Weber
   3. Tom Rhys Marshall
   4. Jill O'Reilly
   5. Laurence Tudor Hunt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors use a clever experimental design and approach to tackle an important set of questions in the field of decision-making. From this work, the authors have a number of intriguing results. However, questions remain regarding the extent to which a number of alternative models and interpretations, not considered in the paper, could account for the observed effects.

   Reviewed by eLife

9. Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

   This article has 15 authors:

   1. Abby Sarkar
   2. Yinhua Jin
   3. Brian C DeFelice
   4. Catriona Y Logan
   5. Yan Yang
   6. Teni Anbarchian
   7. Peng Wu
   8. Maurizio Morri
   9. Norma F Neff
   10. Huy Nguyen
   11. Eric Rulifson
   12. Matthew Fish
   13. Avi Gurion Kaye
   14. Azalia M Martínez Jaimes
   15. Roel Nusse

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors report that, in the murine liver, intermittent fasting alters the homeostatic regenerative programme. This has fundamental implications for the use of murine models to study liver regeneration and cancer and highlights through a series of solid mechanistic studies the role of FGF/Wnt signalling interactions in modulating fasted associated regeneration. It opens up further questions as to why this occurs, how this is beneficial to adapting to a fasting state, and the potential for translation.

   Reviewed by eLife

10. EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry

    This article has 17 authors:

    1. Haitao Luan
    2. Timothy A Bielecki
    3. Bhopal C Mohapatra
    4. Namista Islam
    5. Insha Mushtaq
    6. Aaqib M Bhat
    7. Sameer Mirza
    8. Sukanya Chakraborty
    9. Mohsin Raza
    10. Matthew D Storck
    11. Michael S Toss
    12. Jane L Meza
    13. Wallace B Thoreson
    14. Donald W Coulter
    15. Emad A Rakha
    16. Vimla Band
    17. Hamid Band

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study, supported by reasonably solid evidence, will be of interest to breast cancer researchers. The finding that EHD2 promotes tumor growth and impacts store-operated calcium entry (SOCE) adds to our understanding of breast cancer cell physiology. If supported by further research, the study provides a rationale for using SOCE inhibitors in a subset of breast cancers, with high expression of EHD2 serving as a potential predictive biomarker for using SOCE inhibitors.

    Reviewed by eLife