eLife

Latest preprint reviews

1. Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

   This article has 10 authors:

   1. Artur Meller
   2. Jeffrey M Lotthammer
   3. Louis G Smith
   4. Borna Novak
   5. Lindsey A Lee
   6. Catherine C Kuhn
   7. Lina Greenberg
   8. Leslie A Leinwand
   9. Michael J Greenberg
   10. Gregory R Bowman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents insights into how conformational dynamics differentially influences drug specificity and affinity in myosin isoforms using computational approaches. The evidence supporting the conclusions is convincing, establishing a relationship between inhibition and protein dynamics using state of the art computational techniques followed by experimental validation. The work will be of broad interest to computational biophysicists and medicinal chemists.

   Reviewed by eLife

2. Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes

   This article has 24 authors:

   1. Amelie A Raz
   2. Gabriela S Vida
   3. Sarah R Stern
   4. Sharvani Mahadevaraju
   5. Jaclyn M Fingerhut
   6. Jennifer M Viveiros
   7. Soumitra Pal
   8. Jasmine R Grey
   9. Mara R Grace
   10. Cameron W Berry
   11. Hongjie Li
   12. Jasper Janssens
   13. Wouter Saelens
   14. Zhantao Shao
   15. Chun Hu
   16. Yukiko M Yamashita
   17. Teresa Przytycka
   18. Brian Oliver
   19. Julie A Brill
   20. Henry Krause
   21. Erika L Matunis
   22. Helen White-Cooper
   23. Stephen DiNardo
   24. Margaret T Fuller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides further detailed analysis of recently published Fly Atlas data supplemented with newly generated single cell RNA-seq data. Through characterizing these datasets, the authors define different germ cell and somatic cell clusters throughout the testis. This work confirms and extends previous observations regarding the changing gene expression programs these cells exhibit during their differentiation. This manuscript provides an important and detailed foundation for future studies of these lineages.

   Reviewed by eLife

3. Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

   This article has 14 authors:

   1. Holly Y Chen
   2. Manju Swaroop
   3. Samantha Papal
   4. Anupam K Mondal
   5. Hyun Beom Song
   6. Laura Campello
   7. Gregory J Tawa
   8. Florian Regent
   9. Hiroko Shimada
   10. Kunio Nagashima
   11. Natalia de Val
   12. Samuel G Jacobson
   13. Wei Zheng
   14. Anand Swaroop

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work provides an important pipeline for high-throughput screening platform to be used for drug discovery. The current data are incomplete. Further validation of human patients-derived iPSC clones and functional assays in mice will strengthen the conclusion.

   Reviewed by eLife

4. Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

   This article has 13 authors:

   1. Bryn D Webb
   2. Sara M Nowinski
   3. Ashley Solmonson
   4. Jaya Ganesh
   5. Richard J Rodenburg
   6. Joao Leandro
   7. Anthony Evans
   8. Hieu S Vu
   9. Thomas P Naidich
   10. Bruce D Gelb
   11. Ralph J DeBerardinis
   12. Jared Rutter
   13. Sander M Houten

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is a first report of a human subject with an MCAT mutation showing reduced mitochondrial activity, but without defining the molecular mechanism connecting the loss of MCAT activity to mitochondrial dysfunction. It adds to the important field of mitochondrial disease genes and how they impact human physiology.

   Reviewed by eLife

5. A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

   This article has 8 authors:

   1. Justin L Roncaioli
   2. Janet Peace Babirye
   3. Roberto A Chavez
   4. Fitty L Liu
   5. Elizabeth A Turcotte
   6. Angus Y Lee
   7. Cammie F Lesser
   8. Russell E Vance

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports important findings on the mechanisms by which death pathways are activated by Shigella infection to impact the host response. The methods used provide compelling evidence for the involvement of multiple death cell pathways in the pathogenesis and host response to murine shigellosis. The results presented therein will be of interest to investigators in the field of bacterial pathogenesis, infectious disease and immunology.

   Reviewed by eLife

6. Tyramine and its Amtyr1 receptor modulate attention in honey bees (Apis mellifera)

   This article has 11 authors:

   1. Joseph S Latshaw
   2. Reece E Mazade
   3. Mary Petersen
   4. Julie A Mustard
   5. Irina Sinakevitch
   6. Lothar Wissler
   7. Xiaojiao Guo
   8. Chelsea Cook
   9. Hong Lei
   10. Jürgen Gadau
   11. Brian Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This article reports the fundamental discovery that interfering with the function of the tyramine receptor causes a rapid decline in responses to olfactory stimuli in the honey bee. While tyramine signaling might specifically control the process of latent inhibition without affecting appetitive conditioning, the present analysis is incomplete in terms of ruling out the possibility that tyramine affects other functions of the antennal lobe. Nonetheless, compelling data highlight the role of one of the most highly expressed biogenic amine receptors in the insect olfactory system.

   Reviewed by eLife

7. Spatiotemporal ecological chaos enables gradual evolutionary diversification without niches or tradeoffs

   This article has 3 authors:

   1. Aditya Mahadevan
   2. Michael T Pearce
   3. Daniel S Fisher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study explores the question of "what gives rise to micro-diversity in ecological settings", and proposes a scenario of spatiotemporal chaos, in which interactions between strains drive large changes in the relative abundances of strains. The presented theoretical approach is compelling and goes beyond the current state of the art. This innovative theoretical work is of broad interest to the field of ecology and evolution.

   Reviewed by eLife

8. Femora from an exceptionally large population of coeval ornithomimosaurs yield evidence of sexual dimorphism in extinct theropod dinosaurs

   This article has 4 authors:

   1. Romain Pintore
   2. Raphaël Cornette
   3. Alexandra Houssaye
   4. Ronan Allain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important contribution to the field of dinosaur palaeontology. The authors provide convincing evidence for sexual dimorphism in dinosaurs, based on limb bones of ornithomimosaurs from the Cretaceous of France. The article makes several valuable and important contributions -- including the use of a large dataset and robust statistical approaches -- and will serve as a benchmark for future studies on dinosaurs and other fossil reptiles.

   Reviewed by eLife

9. The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta

   This article has 14 authors:

   1. Sima Stroganov
   2. Talia Harris
   3. Liat Fellus-Alyagor
   4. Lital Ben Moyal
   5. Romina Plitman Mayo
   6. Ofra Golani
   7. Dana Hirsch
   8. Shifra Ben-Dor
   9. Alexander Brandis
   10. Tevie Mehlman
   11. Michal Kovo
   12. Tal Biron-Shental
   13. Nava Dekel
   14. Michal Neeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding of the role of under investigated pathway associated with development of placental oxygenation during pregnancy. The evidence supporting the claims of the authors is incomplete, although inclusion of a larger number of patient samples and an animal model have strengthened the study. The work will be of interest to developmental biologists working on placental function.

   Reviewed by eLife

10. A hardware system for real-time decoding of in vivo calcium imaging data

    This article has 10 authors:

    1. Zhe Chen
    2. Garrett J Blair
    3. Changliang Guo
    4. Jim Zhou
    5. Juan-Luis Romero-Sosa
    6. Alicia Izquierdo
    7. Peyman Golshani
    8. Jason Cong
    9. Daniel Aharoni
    10. Hugh T Blair

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study demonstrates ultrafast real-time decoding of place fields in the hippocampus thanks to a head-mounted microscope for calcium imaging and to a novel data processing pipeline. This is a useful tool that aims at obtaining real-time capabilities that will enable closed-loop experiments that include decoding of a wide neuronal population, which could be applied in a variety of neuroscience fields. This will be of interest to anyone studying behaviors or functions that involve the hippocampus.

    Reviewed by eLife