eLife

Latest preprint reviews

1. The functional form of value normalization in human reinforcement learning

   This article has 2 authors:

   1. Sophie Bavard
   2. Stefano Palminteri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     It is well established that valuation and value-based decision making is context-dependent, but the exact form of normalization has remained an open question. This study provides compelling evidence that values during reward learning are normalized based on the range of available values. These findings will be important for researchers interested in reward learning and decision-making.

   Reviewed by eLife

2. Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity

   This article has 17 authors:

   1. Guillem Torcal Garcia
   2. Elisabeth Kowenz-Leutz
   3. Tian V Tian
   4. Antonis Klonizakis
   5. Jonathan Lerner
   6. Luisa De Andres-Aguayo
   7. Valeriia Sapozhnikova
   8. Clara Berenguer
   9. Marcos Plana Carmona
   10. Maria Vila Casadesus
   11. Romain Bulteau
   12. Mirko Francesconi
   13. Sandra Peiro
   14. Philipp Mertins
   15. Kenneth Zaret
   16. Achim Leutz
   17. Thomas Graf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript describes how methylation of a single arginine residue in a transcription factor, C/EBPα, can alter dynamics of cell fate transition. The study provides one of the most striking examples of the transcription factor regulation by methylation and is well-executed, with compelling evidence to support the authors' claims.

   Reviewed by eLife

3. Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

   This article has 8 authors:

   1. Talia Fargason
   2. Naiduwadura Ivon Upekala De Silva
   3. Erin Powell
   4. Zihan Zhang
   5. Trenton Paul
   6. Jamal Shariq
   7. Steve Zaharias
   8. Jun Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study convincingly demonstrates that the splicing factor SRSF1 can be solubilized in the presence of short RS or ER-containing peptides, and uses this discovery to determine the solution NMR structure of SRSF1, as well as to map its interactions with RS peptides. These findings are important in that SR proteins are key regulators of alternative splicing but their study has been greatly hampered by their low solubility. The development of a general method that allows the structural and biochemical analysis of SR proteins in solution will have broad applications.

   Reviewed by eLife

4. Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

   This article has 3 authors:

   1. Owen Leddy
   2. Forest M White
   3. Bryan D Bryson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This landmark study uses compelling approaches such as quantitative and screening mass spectrometry to identify peptides from tuberculosis bacteria that are presented by macrophages infected with this pathogen. The authors provide convincing evidence that the presentation of these antigens depends on a specialist bacterial secretion system. The study will be of interest to infectious disease specialists and of particular value for future vaccine development.

   Reviewed by eLife

5. Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation

   This article has 17 authors:

   1. Eline Lemerle
   2. Jeanne Lainé
   3. Marion Benoist
   4. Gilles Moulay
   5. Anne Bigot
   6. Clémence Labasse
   7. Angéline Madelaine
   8. Alexis Canette
   9. Perrine Aubin
   10. Jean-Michel Vallat
   11. Norma B Romero
   12. Marc Bitoun
   13. Vincent Mouly
   14. Isabelle Marty
   15. Bruno Cadot
   16. Laura Picas
   17. Stéphane Vassilopoulos

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Lemerle et al utilize advanced correlative light and electron microscopy and molecular biology approaches to convincingly demonstrate the presence of the membrane-bending protein Bin1 and caveolae containing rings capable of membrane tubulation in developing muscle. The data is highly significant as it potentially advances our fundamental understanding of how transverse tubules are formed, a significant gap in our understanding of excitation-contraction coupling and muscle biology more broadly.

   Reviewed by eLife

6. Defining basic rules for hardening influenza A virus liquid condensates

   This article has 10 authors:

   1. Temitope Akhigbe Etibor
   2. Silvia Vale-Costa
   3. Sindhuja Sridharan
   4. Daniela Brás
   5. Isabelle Becher
   6. Victor Hugo Mello
   7. Filipe Ferreira
   8. Marta Alenquer
   9. Mikhail M Savitski
   10. Maria-João Amorim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work presented is fundamental to the field of negative-sense RNA viruses. It showcases a compelling set of ideas and approaches to study some physicochemical properties of organelles in live cells during a viral infection. However, the conclusions could benefit by adding a deeper theoretical approach and additional experimental support.

   Reviewed by eLife

7. The deep-rooted origin of disulfide-rich spider venom toxins

   This article has 2 authors:

   1. Naeem Yusuf Shaikh
   2. Kartik Sunagar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important survey of disulfide-rich peptides (DRPs), which comprise a large fraction of the most functionally important components of spider venom. While spider DRPs were thought to have evolved independently numerous times throughout the spider tree of life, the authors make a solid case for the idea that they all stem from a single common ancestral protein. The study makes a significant advance towards formalizing the diversity of spider venoms, which will be of interest both to scientists working on protein evolution and to those working on functional venomics.

   Reviewed by eLife

8. The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice

   This article has 7 authors:

   1. Mathieu Amand
   2. Philipp Adams
   3. Rafaela Schober
   4. Gilles Iserentant
   5. Jean-Yves Servais
   6. Michel Moutschen
   7. Carole Seguin-Devaux

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The present study presents the important finding that HIV infection activates the NLRP3, IFI16, and AIM 2 inflammasome pathways and that treatment with the anti-caspase 1 inhibitor VX-765 moderately reduces inflammasome activation and CD4 T cell depletion in a humanized NSG mouse model. The evidence supporting that inflammasome activation may play an important role in CD4 T cell depletion and that anti-caspase-1 inhibitors may reduce harmful inflammation is for the most part solid, although not always complete. The results will be of interest to scientists and physicians working on HIV immunology, pathogenesis and cure strategies.

   Reviewed by eLife

9. The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

   This article has 12 authors:

   1. Xiao-Lan Liu
   2. Yulin Yang
   3. Yue Hu
   4. Jingjing Wu
   5. Chuqiao Han
   6. Qiaojia Lu
   7. Xihui Gan
   8. Shaohua Qi
   9. Jinhu Guo
   10. Qun He
   11. Yi Liu
   12. Xiao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides evidence for CPC-3 mediating induction of the transcription factor CPC-1 in starved Neurospora cells, with CPC-1-mediated recruitment of Gcn5 and acetylation of the FRQ promoter counteracting the function of histone deacetylase HDA1, which in turn maintains high occupancy of the transcription factor WCC and attendant circadian rhythm of FRQ expression. The findings are significant in showing how the well-established pathways for circadian rhythm centered on FRQ gene expression and cross-pathway control centered on CPC-1 induction are integrated to maintain rhythmic cell growth in the face of amino acid limitation. However, the evidence for these claims is incomplete in certain respects and additional statistical analyses and experimental evidence are needed to better support the claims of rhythmic CPC-1 binding at FRQ, of the role of GCN-5 in rhythmic FRQ transcription in starvation conditions, and of rhythmic transcription of CPC-1-regulated amino acid biosynthetic genes.

   Reviewed by eLife

10. Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14)

    This article has 13 authors:

    1. Guang Lin
    2. Burak Tepe
    3. Geoff McGrane
    4. Regine C Tipon
    5. Gist Croft
    6. Leena Panwala
    7. Amanda Hope
    8. Agnes JH Liang
    9. Zhongyuan Zuo
    10. Seul Kee Byeon
    11. Lily Wang
    12. Akhilesh Pandey
    13. Hugo J Bellen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This work is of significant interest to those studying neurodegeneration, demonstrating key pathologies in PLA2G6-associated disease in both patient-derived neuronal models and a novel trans heterozygote mouse model. Moreover, it identifies a number of possible compounds that could potentially be re-purposed for therapeutic use in PLA2G6-associated neurodegeneration. Lastly, it shows a proof-of-principle in a mouse model that gene therapy with human PLA2G6 can rescue defects in PLA2G6 deficiency. Whilst the majority of the data are solid and convincing, there are a number of consolidatory experiments that would add greatly to the overall impact and novelty of the work.

    Reviewed by eLife