eLife

Latest preprint reviews

1. Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

   This article has 6 authors:

   1. Angela M Phillips
   2. Daniel P Maurer
   3. Caelan Brooks
   4. Thomas Dupic
   5. Aaron G Schmidt
   6. Michael M Desai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, authors convincingly show that epistasis between mutations plays an important role in the evolution of broadly neutralizing influenza antibodies. Although the data are convincing, several parts of the manuscript require more accurate description.

   Reviewed by eLife

2. Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

   This article has 9 authors:

   1. Mi Huang
   2. Daniel Coral
   3. Hamidreza Ardalani
   4. Peter Spegel
   5. Alham Saadat
   6. Melina Claussnitzer
   7. Hindrik Mulder
   8. Paul W Franks
   9. Sebastian Kalamajski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study provides a fundamental framework for linking human genome variation to targetable mechanisms of disease. The authors provide compelling evidence that a strong candidate locus associates with body weight in humans acts through adipocyte MTIF3. Thus, the generalized approaches taken in this study have the potential to inform genetic association studies in general and lay a foundation for future functional genomics studies.

   Reviewed by eLife

3. Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

   This article has 14 authors:

   1. Camryn Pajon
   2. Marla C Fortoul
   3. Gabriela Diaz-Tang
   4. Estefania Marin Meneses
   5. Ariane R Kalifa
   6. Elinor Sevy
   7. Taniya Mariah
   8. Brandon Toscan
   9. Maili Marcelin
   10. Daniella M Hernandez
   11. Melissa M Marzouk
   12. Allison J Lopatkin
   13. Omar Tonsi Eldakar
   14. Robert P Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How the pathogens Pseudomonas aeruginosa and Staphylococcus aureus compete and co-occur within opportunistic infections is a topic of broad significance, but the major drivers of these interactions remain unclear. Here the authors defined parameters that predict the coexistence of these microbes using their absolute growth in certain nutritional conditions, leading to questions about how other nutrients lead to the dominance of one or the other during infections. Within a confined context, this valuable study provides solid support for a novel framework in which to evaluate this clinically important species interaction.

   Reviewed by eLife

4. Embryo-derive TNF promotes decidualization via fibroblast activation

   This article has 10 authors:

   1. Si-Ting Chen
   2. Wen-Wen Shi
   3. Yu-Qian Lin
   4. Zhen-Shan Yang
   5. Ying Wang
   6. Meng-Yuan Li
   7. Yue Li
   8. Ai-Xia Liu
   9. Yali Hu
   10. Zeng-Ming Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors provide novel evidence for a connection between fibroblast activation and eutherian stromal decidualization. This important work substantially advances our understanding of decidua biology and its contribution to pregnancy. The authors are using solid evidence to support the findings. The methodology includes in vivo mouse and human stroma cells is broadly supports the claims with only minor weaknesses.

   Reviewed by eLife

5. A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

   This article has 9 authors:

   1. Huaming Xu
   2. Zhijian Li
   3. Chao-Chung Kuo
   4. Katrin Götz
   5. Thomas Look
   6. Marcelo AS de Toledo
   7. Kristin Seré
   8. Ivan G Costa
   9. Martin Zenke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Authors provide valuable evidence identifying a lncRNA transcribed specifically in the pDC subtype from the +32Kb promoter region which is also the region for the enhancer for Irf8 specifically in the cDC1 subtype. With convincing methodology, they provide in-depth analysis about the possible role of lncIrf8, and its promoter region and cross-talk with Irf8 promoter to identify that it is not the lncIRF8 itself but its promoter region that is crucial for pDC and cDC1 differentiation conferring feedback inhibition of Irf8 transcription. The work will be of interest to immunologists working on immune cell development.

   Reviewed by eLife

6. Impaired iron recycling from erythrocytes is an early hallmark of aging

   This article has 17 authors:

   1. Patryk Slusarczyk
   2. Pratik Kumar Mandal
   3. Gabriela Zurawska
   4. Marta Niklewicz
   5. Komal Chouhan
   6. Raghunandan Mahadeva
   7. Aneta Jończy
   8. Matylda Macias
   9. Aleksandra Szybinska
   10. Magdalena Cybulska-Lubak
   11. Olga Krawczyk
   12. Sylwia Herman
   13. Michal Mikula
   14. Remigiusz Serwa
   15. Małgorzata Lenartowicz
   16. Wojciech Pokrzywa
   17. Katarzyna Mleczko-Sanecka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Slusarczyk et al demonstrate that red pulp macrophages (RPM), specialized splenic cells that clear senescent red blood cells through erythrophagocytosis, show diminished function in aging mice. This impairment leads to retention of hemolytic red blood cells and formation of extracellular aggregates which further exacerbate RPM demise. Iron restriction alleviates most of these symptoms in aging RPMs. They propose RPM collapse as an early indicator of aging that could be reversed through iron limitation.

   Reviewed by eLife

7. The entorhinal-DG/CA3 pathway in the medial temporal lobe retains visual working memory of a simple surface feature

   This article has 6 authors:

   1. Weizhen Xie
   2. Marcus Cappiello
   3. Michael A Yassa
   4. Edward Ester
   5. Kareem A Zaghloul
   6. Weiwei Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study highlights the contribution of the medial temporal lobe (MTL), and the DG/CA3 hippocampal pathway in particular, to neural activity during the working memory delay period. The evidence supporting this is compelling, using diverse state-of-the-art approaches to neural data analysis and relating it to behavioural data. The work will be of significant interest to neuroscientists specialising in the research area of human working memory.

   Reviewed by eLife

8. B cell receptor-induced IL-10 production from neonatal mouse CD19+CD43- cells depends on STAT5-mediated IL-6 secretion

   This article has 5 authors:

   1. Jiro Sakai
   2. Jiyeon Yang
   3. Chao-Kai Chou
   4. Wells W Wu
   5. Mustafa Akkoyunlu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present valuable findings about the mechanisms inducing IL-10 production by B cells in neonates. The evidence supporting the claims of the authors is solid, although the manuscript would be strengthened by amendments to the presentation of the data and explanation of some experimental choices.

   Reviewed by eLife

9. Protein composition of axonal dopamine release sites in the striatum

   This article has 3 authors:

   1. Lauren Kershberg
   2. Aditi Banerjee
   3. Pascal S Kaeser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using in-vivo proximity labeling using three different presynaptic proteins the authors have carried out a comprehensive proteome analysis of axonal dopamine release sites, resulting in the identification of many new presynaptic candidate proteins. Genetic deletion of the active zone protein RIM1 but not of the presynaptic calcium sensor synaptotagmin 1 resulted in a loss of enrichment indicative of a disruption of the active zone. Although the functional significance of many of the novel proteins will require future corroboration, the analysis provides a valuable and high-quality dataset as a starting point for future investigations.

   Reviewed by eLife

10. Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells

    This article has 13 authors:

    1. Yasunari Seita
    2. Keren Cheng
    3. John R McCarrey
    4. Nomesh Yadu
    5. Ian H Cheeseman
    6. Alec Bagwell
    7. Corinna N Ross
    8. Isamar Santana Toro
    9. Li-hua Yen
    10. Sean Vargas
    11. Christopher S Navara
    12. Brian P Hermann
    13. Kotaro Sasaki

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper describes a method for robust differentiation of the common marmoset induced pluripotent stem cells (iPSCs) into primordial germ cell-like cells and subsequently into spermatogonia-like cells when combined with testis somatic cells. The data suggest that marmosets are very similar to humans and macaques. The paper is nicely done but needs further characterization and a better explanation of the methodology.

    Reviewed by eLife