eLife

Latest preprint reviews

1. Association between bisphosphonate use and COVID-19 related outcomes

   This article has 12 authors:

   1. Jeffrey Thompson
   2. Yidi Wang
   3. Tobias Dreischulte
   4. Olga Barreiro
   5. Rodrigo J Gonzalez
   6. Pavel Hanč
   7. Colette Matysiak
   8. Harold R Neely
   9. Marietta Rottenkolber
   10. Thomas Haskell
   11. Stefan Endres
   12. Ulrich H von Andrian

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors have used an extensive database to study associations between biphosphanate use and COVID-19. Using careful statistical analyses biphosphonate use appeared strongly associated with a lower risk of COVID-19. If these findings are confirmed in well-designed prospective studies biphosphanate use could be an attractive drug to prevent COVID-19.

   Reviewed by eLife

2. Quantitative proteomic analysis of skeletal muscles from wild-type and transgenic mice carrying recessive Ryr1 mutations linked to congenital myopathies

   This article has 8 authors:

   1. Jan Eckhardt
   2. Alexis Ruiz
   3. Stéphane Koenig
   4. Maud Frieden
   5. Hervé Meier
   6. Alexander Schmidt
   7. Susan Treves
   8. Francesco Zorzato

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides a valuable systematic analysis of proteomic profiles associated with a particular murine Ryanodine receptor abnormality. Its analysis technique provides a solid and systematic set of data summarising the differences in different muscle types. The work emerges with insights into pathological mechanism of congenital muscle diseases linked to mutations in a range of other genes related to excitation contraction coupling in workers within the skeletal muscle field.

   Reviewed by eLife

3. Evidence for embracing normative modeling

   This article has 7 authors:

   1. Saige Rutherford
   2. Pieter Barkema
   3. Ivy F Tso
   4. Chandra Sripada
   5. Christian F Beckmann
   6. Henricus G Ruhe
   7. Andre F Marquand

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a rigorous and compelling extension of previous normative modeling work that demonstrates that normative models incorporating lifespan trajectories of structural and functional connectivity provide a strong basis for brain imaging studies across a range of tasks including, univariate group difference assessment, classification, and building regression models. The work is important, rigorous and a valuable contribution to the field.

   Reviewed by eLife

4. An herbal drug combination identified by knowledge graph alleviates the clinical symptoms of plasma cell mastitis patients: A nonrandomized controlled trial

   This article has 11 authors:

   1. Caigang Liu
   2. Hong Yu
   3. Guanglei Chen
   4. Qichao Yang
   5. Zichu Wang
   6. Nan Niu
   7. Ling Han
   8. Dongyu Zhao
   9. Manji Wang
   10. Yuanyuan Liu
   11. Yongliang Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful identification of an herbal drug combination for the treatment of plasma cell mastitis (PCM), a breast inflammation with severe and intense clinical symptoms. The data were collected and analyzed using a solid and in clinical trial of 160 patients (NCT05530226) and can be used as a starting point for understanding how herbal drug combinations could be helpful in the management of PCM patients.

   Reviewed by eLife

5. Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study

   This article has 32 authors:

   1. Kennedy Lushasi
   2. Kirstyn Brunker
   3. Malavika Rajeev
   4. Elaine A Ferguson
   5. Gurdeep Jaswant
   6. Laurie Louise Baker
   7. Roman Biek
   8. Joel Changalucha
   9. Sarah Cleaveland
   10. Anna Czupryna
   11. Anthony R Fooks
   12. Nicodemus J Govella
   13. Daniel T Haydon
   14. Paul CD Johnson
   15. Rudovick Kazwala
   16. Tiziana Lembo
   17. Denise Marston
   18. Msanif Masoud
   19. Matthew Maziku
   20. Eberhard Mbunda
   21. Geofrey Mchau
   22. Ally Z Mohamed
   23. Emmanuel Mpolya
   24. Chanasa Ngeleja
   25. Kija Ng'habi
   26. Hezron Nonga
   27. Kassim Omar
   28. Kristyna Rysava
   29. Maganga Sambo
   30. Lwitiko Sikana
   31. Rachel Steenson
   32. Katie Hampson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents an analysis of both contact tracing and whole-genome sequence data to track the elimination of dog-mediated rabies in Pemba Island, Tanzania. The work is a valuable contribution to the literature as it will have practical implications for the elimination of dog-mediated rabies in other regions/contexts. The main claims made are largely supported, but the strength of evidence for the cost-effectiveness is limited.

   Reviewed by eLife

6. ‘Skeletal Age’ for mapping the impact of fracture on mortality

   This article has 8 authors:

   1. Thach Tran
   2. Thao Ho-Le
   3. Dana Bliuc
   4. Bo Abrahamsen
   5. Louise Hansen
   6. Peter Vestergaard
   7. Jacqueline R Center
   8. Tuan V Nguyen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents the idea of "Skeletal Age", defined as the age of one's skeleton as a consequence of fragility fracture, as a potential new tool to raise awareness about the increased risk of mortality following a fracture (particularly hip fractures) and thus improve the medical management of osteoporosis. The evidence is convincing and is derived from a very large database from the Danish National Hospital Discharge Registry. The proposed approach might represent a starting point for making doctor-patient communication about the health risks of an osteoporotic fracture more intuitive and possibly more effective.

   Reviewed by eLife

7. Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism

   This article has 15 authors:

   1. Michelle C.D. Bridi
   2. Nancy Luo
   3. Grace Kim
   4. Benjamin J. Menarchek
   5. Rachel A. Lee
   6. Bryan Rodriguez
   7. Daniel Severin
   8. Cristian Moreno
   9. Altagracia Contreras
   10. Christian Wesselborg
   11. Caroline O’Ferrall
   12. Ruchit Patel
   13. Sarah Bertrand
   14. Sujatha Kannan
   15. Alfredo Kirkwood

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important finding on the cause of the widely reported disruption of the excitation to inhibition (E-I) ratio change in Autism Spectrum Disorder (ASD) mouse models. The evidence supporting the main conclusions is solid and well-sampled. These results can be a starting point for studies that assess the functional role of daily oscillations of the E-I ratio in the pathophysiology of ASD, and possibly, reshape our understanding of the nature of the E/I balance alterations that contribute to normal and diseased circuits.

   Reviewed by eLife

8. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells

   This article has 10 authors:

   1. Erika Cecon
   2. Atsuro Oishi
   3. Marine Luka
   4. Delphine Ndiaye-Lobry
   5. Arnaud François
   6. Mathias Lescuyer
   7. Fany Panayi
   8. Julie Dam
   9. Patricia Machado
   10. Ralf Jockers

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Understanding specific tau-tau interactions that play key roles in Alzheimer's disease and tauopathies will enable the elucidation of the toxic tau species involved in the pathogenesis of these diseases and therapeutic development in this area. In this paper, the authors developed a series of NanoBiT complementation-based tau biosensors to monitor tau intramolecular and intermolecular interactions. This paper will be of high interest to a broad target audience including researchers in the field of biophysics, biochemistry, cell biology, neuroscience, neuropathology, and drug discovery as well as physicians.

   Reviewed by eLife

9. Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions

   This article has 11 authors:

   1. Irene Navarro Lobato
   2. Adrian Aleman-Zapata
   3. Anumita Samanta
   4. Milan Bogers
   5. Shekhar Narayanan
   6. Abdelrahman Rayan
   7. Alejandra Alonso
   8. Jacqueline van der Meij
   9. Mehdi Khamassi
   10. Zafar U Khan
   11. Lisa Genzel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reveals that slow plasticity in the neocortex is essential to prevent memory interference. The method of artificially increasing plasticity in the prefrontal cortex of rats during learning and its effect on sleep physiology, when memories are believed to be reprocessed, is solid. The work will be of interest to neuroscientists interested in learning and memory.

   Reviewed by eLife

10. Distinct roles of forward and backward alpha-band waves in spatial visual attention

    This article has 4 authors:

    1. Andrea Alamia
    2. Lucie Terral
    3. Malo Renaud D'ambra
    4. Rufin VanRullen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Alamia and colleagues investigate the direction of traveling waves in the alpha frequency band during visual spatial attention. The authors' novel perspective adopted here is valuable to understanding the functional relevance of alpha oscillations for spatial attention. The observed pattern of results is consistent with distinct roles for travelling alpha waves in spatially opposite directions and makes a solid case for considering this new perspective on alpha rhythms in human cognitive function.

    Reviewed by eLife