eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2023.04.15.537018

2. High-throughput Automated Muropeptide Analysis (HAMA) Reveals Peptidoglycan Composition of Gut Microbial Cell Walls

   This article has 6 authors:

   1. Ya-Chen Hsu
   2. Pin-Rui Su
   3. Lin-Jie Huang
   4. Kum-Yi Cheng
   5. Chun-hsien Chen
   6. Cheng-Chih Hsu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports a new approach to determine the architecture of peptidoglycan (PG), the primary component of the bacterial cell wall, validating the pipeline through an architectural analysis of several members of the human gut microbiota. The technique is potentially valuable for this sub-field as it would enable researchers interested in peptidoglycan in a range of organisms to easily assess muropeptide composition in an easy, automated manner. However, there is some uncertainty about whether the pipeline was fully automated and it was noted that the pipeline requires prior knowledge of the peptidoglycan composition of an organism. Additionally, the use of the technique to investigate whether PG cross-bridge length is a determinant of cell wall stiffness produced evidence that would need more direct support and is therefore so far incomplete.

   Reviewed by eLife

3. Diminishing neuronal acidification by channelrhodopsins with low proton conduction

   This article has 5 authors:

   1. Rebecca Frank Hayward
   2. F Phil Brooks
   3. Shang Yang
   4. Shiqiang Gao
   5. Adam E Cohen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important and compelling study investigates the problem of intracellular acidification induced by commonly-used optogenetic stimulating opsins. The low proton permeability of two high-performance opsins is shown to reduce photostimulated acidification. The findings may be of broad interest in the fields of neuroscience research and optogenetic therapies.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2022.11.29.516809

5. A timeline of bacterial and archaeal diversification in the ocean

   This article has 3 authors:

   1. Carolina A Martinez-Gutierrez
   2. Josef C Uyeda
   3. Frank O Aylward

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper addresses the challenging problem of dating the origin of several groups of marine microorganisms. However, while much of the analyses are solid, the lack of robustness analysis in molecular dating component such as using alternative time calibrations, clock models, and input gene sets makes the study incomplete. Despite some concerns, this work is a commendable attempt at an extremely difficult problem and will be of broad interest to microbiologists, geologists, and evolutionary biologists.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2022.01.06.475273

7. Continuous, long-term crawling behavior characterized by a robotic transport system

   This article has 9 authors:

   1. James Yu
   2. Stephanie Dancausse
   3. Maria Paz
   4. Tolu Faderin
   5. Melissa Gaviria
   6. Joseph W Shomar
   7. Dave Zucker
   8. Vivek Venkatachalam
   9. Mason Klein

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study describes a useful method to monitor the behavior of Drosophila larvae in a uniform environment over much longer time scales than was possible with previous methods. The authors provide a solid characterization of aspects of the method and show that the behavior of single larvae can be quantified over several hours. The experiments offer a proof-of-concept for a robotic device that will enable the investigation of behavior in long-term experiments in ways that were previously unimaginable.

   Reviewed by eLife

8. High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

   This article has 8 authors:

   1. George A Spirou
   2. Matthew Kersting
   3. Sean Carr
   4. Bayan Razzaq
   5. Carolyna Yamamoto Alves Pinto
   6. Mariah Dawson
   7. Mark H Ellisman
   8. Paul B Manis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a structural analysis of bushy cells in the mouse cochlear nucleus. These neurons receive a large synaptic contact from the auditory nerve termed an endbulb that preserves the temporal information present in the auditory nerve and are key elements of binaural sound localization circuits. The analysis combines volume electron microscopy techniques with computational models to predict heterogeneous bushy cell responses. The analysis takes morphological analysis of bushy cells to a new level, and the modeling is well done.

   Reviewed by eLife

9. Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis

   This article has 7 authors:

   1. Sotaro Ichinose
   2. Yoshihiro Susuki
   3. Nobutake Hosoi
   4. Ryosuke Kaneko
   5. Mizuho Ebihara
   6. Hirokazu Hirai
   7. Hirohide Iwasaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This potentially important paper investigates the mechanisms that contribute to building inhibitory synapses through differential protein release from microtubules. The experiments are generally designed well, but the evidence supporting the conclusions is incomplete. This manuscript will be of interest to neuroscientists and cell biologists interested in intracellular trafficking and synapse maturation.

   Reviewed by eLife

10. Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)

    This article has 12 authors:

    1. Mengyao Wu
    2. Tak-Ho Lo
    3. Liping Li
    4. Jia Sun
    5. Chujun Deng
    6. Ka-Ying Chan
    7. Xiang Li
    8. Steve Ting-Yuan Yeh
    9. Jimmy Tsz Hang Lee
    10. Pauline Po Yee Lui
    11. Aimin Xu
    12. Chi-Ming Wong

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      These valuable findings presented by Wu et al. advance our understanding in novel cell signaling regulators of hepatic metabolism. The evidence supporting these conclusions are solid, utilizing in vivo and in vitro gain and loss of function studies. These work will be of interest to biologists working in the field of hepatic steatosis.

    Reviewed by eLife