eLife

Latest preprint reviews

1. Extinction risk in terrestrial vertebrates is associated with niche limits that reflect climatic vulnerability

   This article has 2 authors:

   1. Matthew Nagy-Watson
   2. Jeremy T Kerr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the relationship between climatic niche limits and extinction risk across more than 23,000 terrestrial vertebrate species. The large comparative dataset and phylogenetic analyses indicate solid evidence that species with lower upper thermal niche limits are more likely to be classified as threatened, whereas associations with aridity limits are less consistent. However, the treatment of data-deficient species and unclear definitions of niche metrics warrant further scrutiny, and the analyses do not establish that climate or land-use change drives the observed patterns. The findings will interest researchers in macroecology, global change biology, and conservation.

   Reviewed by eLife

2. Number, order and time influence how the brain integrates distinct experiences

   This article has 5 authors:

   1. Alina B Thomas
   2. Francesca S Wong
   3. A Simon Killcross
   4. Fred Westbrook
   5. Nathan M Holmes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides an important set of findings using sensory preconditioning procedures that advance our understanding of the circumstances that influence the integration of discrete learning experiences. The evidence supporting the conclusions is solid, as the study used multiple different conditions to differentiate between different theories of memory integration. Moreover, the findings should be of broader interest to the learning and memory field for considering the role of the medial temporal lobe in how separate experiences are integrated.

   Reviewed by eLife

3. High-dimensional Characterization of Genome–Environment Fitness Landscapes in Klebsiella pneumoniae

   This article has 15 authors:

   1. Ge Zhou
   2. Georgia Williams
   3. Mathew T Millner
   4. Raneem AlHirayban
   5. Wejdan Alosaimi
   6. Omniya Fallatah
   7. Adam J Hart
   8. Mohammed Malaikah
   9. Sara Iftikhar
   10. Huda Ahmad
   11. Mohammad Roghanian
   12. Ville Mustonen
   13. Rfeef AlYami
   14. Manuel Banzhaf
   15. Danesh Moradigaravand

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable mapping of how genomic variation from a large collection of Klebsiella pneumoniae clinical isolates shapes bacterial fitness across 214 conditions. Solid data describe that fitness is strongly condition-dependent and that features can be advantageous under selection. Though the predictive, plasmid causality and GWAS association findings would be further strengthened by additional analyses ruling out population-structure confounding, these findings are of value for our understanding of the power of genotype to predict phenotype for this human pathogen.

   Reviewed by eLife

4. Psilocybin asymmetrically modulates outcome-based choice and cortical processing under uncertainty

   This article has 5 authors:

   1. David Jacobs
   2. Alejandro Torrado Pacheco
   3. Randall Olson
   4. Angela J Langdon
   5. Bita Moghaddam

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript contains exciting data that has the potential to advances understanding of how psilocybin acutely alters decision making by modulating the impact of outcomes on future choices and altering how prefrontal cortex neurons encode outcomes. While the experimental paradigm, behavioral and neural analysis are elegant, the strength of evidence is, at present, incomplete given the lack of a saline treated comparison. This work will be of interest to behavioral and computational neuroscientists studying decision making, flexibility, or psychedelics.

   Reviewed by eLife

5. Thermotaxis behavior of Drosophila melanogaster : A quantitative analysis of sensory-motor integration and heat avoidance

   This article has 5 authors:

   1. Zeinab Moradi
   2. Sara Jahedazad
   3. Ehsan Hosseinian
   4. Tayebeh Minaei
   5. Ali Sadighi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study utilizes a two-choice assay to examine how groups of Drosophila melanogaster respond to temperature changes. The findings are useful, offering focused importance for the collective decision-making community. However, the strength of the evidence is incomplete, as the current data only partially support the primary claims and the work lacks the necessary integration into the existing literature to contextualize the findings.

   Reviewed by eLife

6. Cell junction disruption drives translocation of gasdermin A and gasdermin B from cytoskeleton to plasma membrane during acantholysis

   This article has 3 authors:

   1. Kidong Kang
   2. Ying Wang
   3. Edward A Miao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the cleavage-independent functions of Gasdermins in keratinocytes. The data collected using advanced microscopy methods and Western blotting are solid, but the main conclusions from these experiments remain partially supported. This paper is relevant to those studying cell-type specific inflammatory responses and client/cargo specificities of Gasdermins.

   Reviewed by eLife

7. Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

   This article has 9 authors:

   1. Corey E Hayford
   2. Blake Baleami
   3. Philip E Stauffer
   4. B Bishal Paudel
   5. Aziz Al’Khafaji
   6. Amy Brock
   7. Vito Quaranta
   8. Darren R Tyson
   9. Leonard A Harris

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study uses single-cell profiling, lineage barcoding, and functional assays to examine drug-tolerant persisters in a BRAF-inhibited melanoma cell line. The data provide solid evidence that persisters arise from many lineages and have altered calcium handling and increased sensitivity to ferroptosis, although the lineage result is difficult to interpret without knowing how many cells survived treatment. The broader claim that these cells represent substates within a single persister state is less well supported, as it rests largely on transcriptomic projections, lacks time-resolved data, and has been examined in only one cell line.

   Reviewed by eLife

8. Scale dependence decouple life history traits from transposable element evolution in sauropsids

   This article has 3 authors:

   1. Yun Liang
   2. Bin Zuo
   3. Yan-Bo Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study provides an important empirical assessment of a non-adaptive hypothesis on transposable element evolution grounded in population genetics principles. The results suggest that the impact of genetic drift on transposable element amplification is not global, but depends on the phylogenetic scale being considered and can be overwhelmed by lineage-specific dynamics. The analyses are mostly appropriate, but currently incomplete in some aspects. Former conclusions will require additional crosschecks.

   Reviewed by eLife

9. Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies

   This article has 7 authors:

   1. Runa I Løberg
   2. Helena A Abdi-Dezfuli
   3. Liv Kleppa
   4. Alisa E Dewan
   5. Maureen T Meling
   6. Ludvig M Sollid
   7. M Fleur du Pré

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that induced expression of transglutaminase 2 (TG2) fused to an antigenic peptide in mouse intestinal epithelial cells can trigger an anti-TG2 autoantibody response similar to that seen in celiac disease. The conclusions are supported by convincing evidence from a well-designed mouse model, although some additional experiments would strengthen the study. The work will be of interest to researchers studying celiac disease, other autoimmune conditions, and mucosal immunologists.

   Reviewed by eLife

10. Theta phase and theta-gamma coupling organise the spoken language network

    This article has 8 authors:

    1. Haya Akkad
    2. Daniel Bush
    3. Robert Seymour
    4. Tae Twomey
    5. Susanne Pelke
    6. Sasha Ondobaka
    7. Sven Bestmann
    8. Jenny Crinion

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides useful data on oscillatory coupling during speech planning, particularly suggesting that theta-band phase coupling may differentiate networks involved in object recognition and semantic-lexical retrieval. However, the strength of the evidence is incomplete because the absence of a linguistic manipulation and key confounds between the naming and control conditions limit the ability to attribute the reported effects specifically to word production, leaving the main mechanistic conclusions only partially supported.

    Reviewed by eLife