eLife

Latest preprint reviews

1. Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

   This article has 9 authors:

   1. Maurice A Petroccione
   2. Lianna Y D'Brant
   3. Nurat Affinnih
   4. Patrick H Wehrle
   5. Gabrielle C Todd
   6. Shergil Zahid
   7. Haley E Chesbro
   8. Ian L Tschang
   9. Annalisa Scimemi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports important findings that help to understand the function of glutamate transporters and their effects on synaptic function at D1- and D2-MSNs within the dorsolateral striatum. These findings were evaluated to be of interest and well-executed. Overall, the majority of claims are supported by high quality data, but the evidence for some underlying mechanisms and region specificity were incomplete in the manuscript's current form.

   Reviewed by eLife

2. Competing neural representations of choice shape evidence accumulation in humans

   This article has 6 authors:

   1. Krista Bond
   2. Javier Rasero
   3. Raghav Madan
   4. Jyotika Bahuguna
   5. Jonathan Rubin
   6. Timothy Verstynen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study assesses how change in reward contingency in the environment affects the dynamics of a realistic large-scale neural circuit model, human choice behavior, and fMRI responses measured in the same individuals. It is not entirely clear which predictions of the neural circuit model go beyond previous work, the current results seem incomplete and could likely be substantially strengthened. This study could be of interest to scientists studying the neural and computational bases of adaptive behaviour.

   Reviewed by eLife

3. State-dependent coupling of hippocampal oscillations

   This article has 6 authors:

   1. Brijesh Modi
   2. Matteo Guardamagna
   3. Federico Stella
   4. Marilena Griguoli
   5. Enrico Cherubini
   6. Francesco P Battaglia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Traditional approaches for the analysis of brain rhythms typically rely on measuring spectro-temporal properties of individual oscillations or the interactions between two different oscillations. This manuscript presents a novel multivariate approach that uses a state space model to simultaneously analyze the dynamics and interactions of multiple hippocampal oscillations. Such an approach represents a step forward in the field that highlights the need of taking into account the complexity of network interactions rather than trying to understand each component of the system in isolation.

   Reviewed by eLife

4. Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

   This article has 8 authors:

   1. Briana M Bohannon
   2. Jessica J Jowais
   3. Leif Nyberg
   4. Vanessa Olivier-Meo
   5. Valentina Corradi
   6. D Peter Tieleman
   7. Sara I Liin
   8. H Peter Larsson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work reports important findings regarding the regulation of ion channels by polyunsaturated fatty acids (PUFAs) through the identification of novel aromatic PUFA analogs with potent effects on the IKs channels, which allow for mechanistic insights into their mode of action. The experiments are solid, combining site-directed mutagenesis, electrophysiological and pharmacological approaches to dissect the different molecular mechanisms and sites involved in the functional interactions. This work will be of broad interest to ion channel biophysicists, physiologists, and medical chemists interested in drug development for LQT syndrome. The study presents some limitations that may need to be addressed or further discussed, in order to strengthen the conclusions reached in the study.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.01.26.525665

6. We couldn't get details of this article at this time:
   10.1101/2023.04.02.535275

7. We couldn't get details of this article at this time:
   10.1101/2023.03.21.533660

8. We couldn't get details of this article at this time:
   10.1101/2023.03.07.531563

9. We couldn't get details of this article at this time:
   10.1101/2022.08.08.503143

10. We couldn't get details of this article at this time:
    10.1101/2023.03.13.532446