eLife

Latest preprint reviews

1. Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex

   This article has 3 authors:

   1. Ludovica Bachschmid-Romano
   2. Nicholas G Hatsopoulos
   3. Nicolas Brunel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study provides a recurrent network model of M1 for center-out reaches. The "neurons" in the model show uncorrelated tuning for movement direction during preparation and execution with dynamic transition between the two states. The continuous attractor model provides an interesting example of flexible switching between neural representations.

   Reviewed by eLife

2. Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections

   This article has 14 authors:

   1. Madhura Raghavan
   2. Katrina L Kalantar
   3. Elias Duarte
   4. Noam Teyssier
   5. Saki Takahashi
   6. Andrew F Kung
   7. Jayant V Rajan
   8. John Rek
   9. Kevin KA Tetteh
   10. Chris Drakeley
   11. Isaac Ssewanyana
   12. Isabel Rodriguez-Barraquer
   13. Bryan Greenhouse
   14. Joseph L DeRisi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study describes the use of a new and valuable tool, namely phage display of Plasmodium falciparum proteome-wide peptides, for profiling of antibody targets. The study, conducted using plasma from Ugandan children and adults, represents an important aspect of naturally acquired antibodies with seroreactive responses to the intra-and inter-protein repeat regions. The results are, however, so far incomplete, and confirmatory data that antibodies to inter-protein repeat motifs do cross-react are needed.

   Reviewed by eLife

3. Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis

   This article has 21 authors:

   1. Maria-Bernadette Madel
   2. Julia Halper
   3. Lidia Ibáñez
   4. Lozano Claire
   5. Matthieu Rouleau
   6. Antoine Boutin
   7. Adrien Mahler
   8. Rodolphe Pontier-Bres
   9. Thomas Ciucci
   10. Majlinda Topi
   11. Christophe Hue
   12. Jerome Amiaud
   13. Salvador Iborra
   14. David Sancho
   15. Dominique Heymann
   16. Henri-Jean Garchon
   17. Dorota Czerucka
   18. Florence Apparailly
   19. Isabelle Duroux-Richard
   20. Abdelilah Wakkach
   21. Claudine Blin-Wakkach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this work, the authors provide convincing evidence about the existence of two distinct osteoclast populations with specific expression profiles and properties and show that the probiotic yeast S. boulardii may be useful in managing inflammation-mediated bone loss, including estrogen deprivation-mediated osteoporosis. The reported study aims to bring the concept of heterogeneous osteoclasts into a proof-of-principle therapeutic application, which may mean that the use of probiotics might combat osteoporosis towards a better bone quality than current therapies. The molecular mechanism of how the probiotic yeast S. boulardii treatment acts via the receptors remains obscure since it might act via changes in the gut permeability or by components directly released by the fungus.

   Reviewed by eLife

4. Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

   This article has 38 authors:

   1. William HK Schilling
   2. Podjanee Jittamala
   3. James A Watson
   4. Maneerat Ekkapongpisit
   5. Tanaya Siripoon
   6. Thundon Ngamprasertchai
   7. Viravarn Luvira
   8. Sasithorn Pongwilai
   9. Cintia Cruz
   10. James J Callery
   11. Simon Boyd
   12. Varaporn Kruabkontho
   13. Thatsanun Ngernseng
   14. Jaruwan Tubprasert
   15. Mohammad Yazid Abdad
   16. Nattaporn Piaraksa
   17. Kanokon Suwannasin
   18. Pongtorn Hanboonkunupakarn
   19. Borimas Hanboonkunupakarn
   20. Sakol Sookprome
   21. Kittiyod Poovorawan
   22. Janjira Thaipadungpanit
   23. Stuart Blacksell
   24. Mallika Imwong
   25. Joel Tarning
   26. Walter RJ Taylor
   27. Vasin Chotivanich
   28. Chunlanee Sangketchon
   29. Wiroj Ruksakul
   30. Kesinee Chotivanich
   31. Mauro Martins Teixeira
   32. Sasithon Pukrittayakamee
   33. Arjen M Dondorp
   34. Nicholas PJ Day
   35. Watcharapong Piyaphanee
   36. Weerapong Phumratanaprapin
   37. Nicholas J White
   38. on behalf of the PLATCOV Collaborative Group

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This highly important paper uses a Bayesian linear regression approach in a clinical trial to establish that ivermectin does not increase the clearance rate of SARS-CoV-2 relative to no study drug. The strength of evidence is compelling. Particular strengths are that the paper is clearly written, a novel and important adaptive study design, and linear mixed modeling to account for participant heterogeneity. The work will be of interest to clinicians, statisticians, and public health departments.

   Reviewed by eLife

5. Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

   This article has 11 authors:

   1. Zhuoran Zhao
   2. Xiayu Shen
   3. Shuang Chen
   4. Jing Gu
   5. Haun Wang
   6. Maria F Mojica
   7. Moumita Samanta
   8. Debsindhu Bhowmik
   9. Alejandro J Vila
   10. Robert A Bonomo
   11. Shozeb Haider

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this useful study, the authors utilize state-of-the-art computational methods complemented with some experimental validation to investigate the dynamics of flexible loops of the L1 Metallo-β-lactamase enzyme, resulting in a better understanding of the various conformational states useful for the rational design of superior β-lactamase inhibitors/antibiotics. The evidence supporting the claims is solid, and the work will be of interest to computational, experimental biologists, and drug designers working on antibiotic resistance.

   Reviewed by eLife

6. Molecular characterization of the intact mouse muscle spindle using a multi-omics approach

   This article has 10 authors:

   1. Bavat Bornstein
   2. Lia Heinemann-Yerushalmi
   3. Sharon Krief
   4. Ruth Adler
   5. Bareket Dassa
   6. Dena Leshkowitz
   7. Minchul Kim
   8. Guy Bewick
   9. Robert W Banks
   10. Elazar Zelzer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript is of potential interest for a broad spectrum of researchers working on the nervous and muscular systems. By combining transcriptome and proteome analyses, the authors reveal the molecular makeup of the different compartments of the muscle spindle. The work is novel, makes important observations, and is well-executed and methodologically convincing to provide the field with new tools for dissecting the development and function of the muscle spindle.

   Reviewed by eLife

7. Enhanced single RNA imaging reveals dynamic gene expression in live animals

   This article has 8 authors:

   1. Yucen Hu
   2. Jingxiu Xu
   3. Erqing Gao
   4. Xueyuan Fan
   5. Jieli Wei
   6. Bingcheng Ye
   7. Suhong Xu
   8. Weirui Ma

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this manuscript, the authors devised a new, useful mRNA-imaging approach by combining MS2 and SunTag labeling systems. The authors showed that this new method can be used to image the activation of gene expression and endogenous mRNA dynamics in live C. elegans. While the application in C. elegans has great future potential, this study is incomplete because it lacks essential characterization of the new imaging method to demonstrate that it does not interfere with RNA expression.

   Reviewed by eLife

8. Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

   This article has 7 authors:

   1. Liangyu Zhang
   2. Weston T. Stauffer
   3. John S. Wang
   4. Fan Wu
   5. Zhouliang Yu
   6. Chenshu Liu
   7. Abby F. Dernburg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Zhang et al. present convincing data describing a role for Polo-like kinase PLK-2 in restricting the activity of Chk2 kinase and coordinating synapsis of homologous chromosomes with the progression of meiotic prophase in C. elegans. By revealing PLK-2-dependent and -independent mechanisms of CHK-2 activity, this work provides a valuable understanding of the major regulators of meiotic progression.

   Reviewed by eLife

9. Ecdysone acts through cortex glia to regulate sleep in Drosophila

   This article has 5 authors:

   1. Yongjun Li
   2. Paula Haynes
   3. Shirley L Zhang
   4. Zhifeng Yue
   5. Amita Sehgal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Li and colleague report observations that constitute a potentially fundamental advance, pointing to a mechanism by which non-neural cells can influence sleep regulation by neurons, The authors provide evidence in Drosophila showing that ecdysone synthesised outside the brain regulates sleep via ecdysone receptors in cortex glia. It further suggests that steroid signalling in glia can act on sleep through lipid droplet mobilization.

   Reviewed by eLife

10. Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes

    This article has 3 authors:

    1. Eli Olson
    2. Theadora Ceccarelli
    3. Malini Raghavan

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      In this manuscript, the authors provide mechanisms by which HLA-I polymorphism affects the capacity in the endo-lysosomal assembly of HLA-I molecules for constitutive expression and during cross-presentation. The findings may have implications for allotype-dependent variation in T cell responses to antigens localized in different subcellular compartments. However, additional biochemical and quantitative data is essential to bolster the central claims of the paper.

    Reviewed by eLife