eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2023.02.19.529159

2. Is tumor mutational burden predictive of response to immunotherapy?

   This article has 5 authors:

   1. Carino Gurjao
   2. Dina Tsukrov
   3. Maxim Imakaev
   4. Lovelace J Luquette
   5. Leonid A Mirny

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study examines relationships between tumor mutational burden and the response to immunotherapy, using new data sets along with publicly available data sets. The authors conclude that tumor mutational burden cut-offs are unreliable proxies for predicting the response to therapy, underpinned by solid evidence, but with several caveats and assumptions that leave the central question subject to further inquiry. In summary, this is an interesting study that adds to a growing body of work investigating the particular conditions governing the effectiveness of immunotherapy.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2023.02.22.529525

4. We couldn't get details of this article at this time:
   10.1101/2023.02.18.529008

5. Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

   This article has 6 authors:

   1. Alexandru-Ioan Voda
   2. Kristina Correa
   3. Jonathan Hamp
   4. Chloe Moscrop
   5. Michael Dustin
   6. Luke Jostins-Dean

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study examines the effects of different co-stimulatory pathways on gene expression and chromatin accessibility in T cells, in order to link the role of co-stimulatory proteins to genetic variants associated with inflammatory bowl disease (IBD). The work provides valuable insight into the role of alternative co-stimulatory proteins in controlling T cell responses. However, the data presented and the analyses performed are still incomplete and inconclusive with regards to IBD risk factors.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.03.09.531872

7. Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

   This article has 12 authors:

   1. Eva Morgun
   2. Jennifer Zhu
   3. Sultan Almunif
   4. Sharan Bobbala
   5. Melissa S Aguilar
   6. Junzhong Wang
   7. Kathleen Conner
   8. Yongyong Cui
   9. Liang Cao
   10. Chetan Seshadri
   11. Evan A Scott
   12. Chyung-Ru Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors generate a new formulation built upon a previous nanoparticle platform to generate a new system termed bicontinuous nanospheres (BCN), allowing for the dual incorporation of lipid and protein antigens. The authors generate mycolic acid (MA)-loaded BCN and perform a series of characterization studies to demonstrate the superior performance of this new formulation relative to the original one in terms of antigen persistence, a quality needed to sustain responses after vaccination. This work provides important new insights relevant to the TB vaccine field and it suggests that alternative antigens to proteins could be used in TB vaccine formulations. The data are convincing and will be of interest to individuals working on tuberculosis, vaccines and basic immunology.

   Reviewed by eLife

8. Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

   This article has 16 authors:

   1. Jinyang Wang
   2. Yaxin Wen
   3. Wentao Zhao
   4. Yan Zhang
   5. Furong Lin
   6. Cong Ouyang
   7. Huihui Wang
   8. Lizheng Yao
   9. Huanhuan Ma
   10. Yue Zhuo
   11. Huiying Huang
   12. Xiulin Shi
   13. Liubin Feng
   14. Donghai Lin
   15. Bin Jiang
   16. Qinxi Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is important work that examines hepatic acetate production via ACOT12/18 in starvation and diabetes. The investigators use solid loss of function strategies in cells, including mouse primary hepatocytes, and in vivo mouse experiments to show that ACOTs are necessary for normal acetate production in the context of fasting and type 1 diabetes. Given that acetate is commonly thought to primarily represent a fermentation product, this study is of interest as it describes hepatic pathways converting fatty acids to acetate.

   Reviewed by eLife

9. Mosquito community composition shapes virus prevalence patterns along anthropogenic disturbance gradients

   This article has 6 authors:

   1. Kyra Hermanns
   2. Marco Marklewitz
   3. Florian Zirkel
   4. Anne Kopp
   5. Stephanie Kramer-Schadt
   6. Sandra Junglen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of interest to scientists in the fields of virology, entomology, ecology and epidemiology as the paper explores the drivers of viral and host composition in natural and disturbed ecosystems. The data are of high quality and have been rigorously assessed.However, important additional information on the transmission ecology of these viruses and their relationship with the environment is lacking, making it difficult to interpret the results from a disease ecology perspective.

   Reviewed by eLife

10. Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

    This article has 6 authors:

    1. Manuela Richter
    2. Lila Neahring
    3. Jinghui Tao
    4. Renaldo Sutanto
    5. Nathan H Cho
    6. Sophie Dumont

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The authors compellingly demonstrate that k-fiber length and dynamics are regulated at the level of individual fibers, even in the absence of focused poles, but that unfocused spindles fail to accurately segregate chromosomes, suggesting that coordination of k-fiber length by pole focusing is important for spindle function. This study provides important new information on spindle scaling, extending in an original manner previous work on this topic.

    Reviewed by eLife