eLife

Latest preprint reviews

1. The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression

   This article has 10 authors:

   1. Nehal Gupta
   2. Hanbing Song
   3. Wei Wu
   4. Rovingaile K Ponce
   5. Yone K Lin
   6. Ji Won Kim
   7. Eric J Small
   8. Felix Y Feng
   9. Franklin W Huang
   10. Ross A Okimoto

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper provides insight into a potentially new genetically defined subset of prostate tumors driven by concurrent loss of two tumor suppressor genes. This study both validates previous findings and provides new data that is compelling overall. With some additional statistical and biochemical evidence to support the conclusions, the work would be of interest to cancer biologists studying molecular mechanisms of prostate cancer.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis

   This article has 7 authors:

   1. Masahide Sakabe
   2. Michael Thompson
   3. Nong Chen
   4. Mark Verba
   5. Aishlin Hassan
   6. Richard Lu
   7. Mei Xin

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors identify a novel developmental role for the beta-adrenergic system in the regulation of mammalian cardiac regenerative capacity. Using genetic and pharmacological loss-of-function approaches, the authors identify a link between Yap and β-adrenergic receptor blockade. The conditional genetic loss-of-function studies are a particular strength of the manuscript and provide strong support for the Gas/Yap-dependent nature of the cardiomyocyte proliferative response to beta adrenergic blockade. Given the widespread use of beta blockers in the clinical management of heart failure, the findings are potentially very important. However, further evidence is required to substantiate the induction of bona fide cardiomyocyte proliferation and cardiac regeneration and clarify the associated mechanisms.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration

   This article has 13 authors:

   1. Eunjin Cho
   2. Xiangguo Che
   3. Mary Jasmin Ang
   4. Seongmin Cheon
   5. Jinkyung Lee
   6. Kwang Soo Kim
   7. Chang Hoon Lee
   8. Sang-Yeop Lee
   9. Hee-Young Yang
   10. Changjong Moon
   11. Chungoo Park
   12. Je-Yong Choi
   13. Tae-Hoon Lee

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The research presented in this manuscript is focused on testing the role of peroxiredoxin (Prdx5) and heterogeneous nuclear ribonucleoprotein K (hnRNPK) in bone biology and osteoporosis. Using cell-base and animal models, as well as various experimental methodologies the authors demonstrated that Prdx5 is upregulated during osteogenesis but suppressed during osteoclastogenesis. This novel function Prdx5 was found to be associated with binding and regulation of hnRNPK which controls the expression of genes involved in osteoclastogenesis, such as osteocalcin (Ocn).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

4. Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element

   This article has 8 authors:

   1. Zachary H Williams
   2. Alvaro Dafonte Imedio
   3. Lea Gaucherand
   4. Derek C Lee
   5. Salwa Mohd Mostafa
   6. James P Phelan
   7. John M Coffin
   8. Welkin E Johnson

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work is a bioinformatic analysis of HML-2-like proviruses found in the genomes of Rhesus Macaques, which convincingly argues that an HML-2 provirus underwent an ancient recombination event with a HERV-K (HML-8) related virus. The authors also provide data to suggest that the recombinant retrovirus may have acquired a distinct mechanism for the regulation of expression of spliced and unspliced transcripts. This paper should be of broad interest to virologists as it uses molecular 'fossil-like' evidence contained in the genomes of modern pirates to document the generation of what could be considered a previously undescribed retrovirus species, through recombination.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

5. Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons

   This article has 7 authors:

   1. Zinan Wang
   2. Joseph P Receveur
   3. Jian Pu
   4. Haosu Cong
   5. Cole Richards
   6. Muxuan Liang
   7. Henry Chung

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is an extensive analysis of the underlying basis of desiccation resistance in 50 Drosophila species from diverse habitats. The work suggests that the longer methyl-branched alkanes (mbCHC) of the cuticular hydrocarbons are critical for this resistance. The study, which informs on the evolution of desiccation resistance in flies, is well done, although the main hypothesis is currently only partially supported by coating experiments, which presently lack controls and would be greatly strengthened by "replacement" experiments to add mbCHCs to flies without CHCs. The work is of relevance to evolutionary biologists in general.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Spatiotemporal properties of glutamate input support direction selectivity in the dendrites of retinal starburst amacrine cells

   This article has 10 authors:

   1. Prerna Srivastava
   2. Geoff de Rosenroll
   3. Akihiro Matsumoto
   4. Tracy Michaels
   5. Zachary Turple
   6. Varsha Jain
   7. Santhosh Sethuramanujam
   8. Benjamin L Murphy-Baum
   9. Keisuke Yonehara
   10. Gautam Bhagwan Awatramani

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an important paper that addresses a key mechanism that underlies the canonical computation of direction selectivity in the retina. By using fluorescence imaging of glutamate release from excitatory interneurons combined with a computational model of dendritic integration, the authors make a convincing case that the kinetics of glutamate release contributes to the direction-selectivity of individual neural processes in retinal neurons. This work will appeal to visual neuroscientists as well as cellular physiologists interested in dendritic computations.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

7. Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus

   This article has 10 authors:

   1. Constance Kleijwegt
   2. Florent Bressac
   3. Coline Seurre
   4. Wilhelm Bouchereau
   5. Camille Cohen
   6. Pascale Texier
   7. Thomas Simonet
   8. Laurent Schaeffer
   9. Patrick Lomonte
   10. Armelle Corpet

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript, of interest to the fields of animal immunity and epigenetics, the authors investigate the crosstalk between PML Nuclear Bodies and HIRA, a member of the H3.3 histone chaperone complex, during inflammatory stress. This study raises interesting perspectives on how availability of HIRA could be regulated by PML Nuclear Bodies for histone deposition onto interferon-stimulated genes, which in turn, could be relevant for immune-response mediated gene regulation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive memories in Drosophila

   This article has 14 authors:

   1. Carlotta Pribbenow
   2. Yi-chun Chen
   3. Michael-Marcel Heim
   4. Desiree Laber
   5. Silas Reubold
   6. Eric Reynolds
   7. Isabella Balles
   8. Raquel Suárez Grimalt
   9. Carolin Rauch
   10. Jörg Rösner
   11. Gregor Lichtner
   12. Sridhar R. Jagannathan
   13. Tania Fernández-d.V. Alquicira
   14. David Owald

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Synaptic plasticity can take place on the presynaptic and/or postsynaptic sites, and these two sites of plasticity are known to involve distinct mechanisms. Using a combined approach of physiology, Drosophila genetics, and behaviour, this study provides evidence that postsynaptic mechanisms underlie plasticity for olfactory learning. This complements the field knowledge that olfactory associative learning largely relies on the presynaptic mechanism in mushroom body neurons. The paper also emphasizes the similarities in learning and memory mechanisms between vertebrates and invertebrates.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

9. Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function

   This article has 7 authors:

   1. Logesvaran Krshnan
   2. Wingyan Skyla Siu
   3. Michael Van de Weijer
   4. Daniel Hayward
   5. Elena Navarro Guerrero
   6. Ulrike Gruneberg
   7. Pedro Carvalho

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The paper provides fundamental information through the identification of an E3 ligase and kinase/phosphatase regulatory machinery that regulates the inner nuclear membrane protein SUN2 using a GFP-based assay. The data reveal a model involving extraction of ubiquitylation of SUN2 from the membrane by p97, which is an important contribution to the field. Although the biochemical evidence is solid on the GFP-tagged SUN2 protein, one question is the extent to which this pathway works on endogenous SUN2 and the extent to which this is a quality control mechanism for turnover of unassembled SUN2 or whether it acts on the fully assembled complex.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3

    This article has 2 authors:

    1. Alonso Javier Pardal
    2. Andrew James Bowman

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This is a very fundamental study that challenges the paradigm that histones H3 and H4 are imported to the nucleus primarily as heterodimers. Instead this study provides compelling evidence that H3 and H4 are imported by importin 5 as monomers and dimerize on chaperones in the nucleus. The work is of relevance to colleagues studying nuclear import and epigenetic regulation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife