eLife

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1. Temporal integration is a robust feature of perceptual decisions

   This article has 6 authors:

   1. Alexandre Hyafil
   2. Jaime de la Rocha
   3. Cristina Pericas
   4. Leor N Katz
   5. Alexander C Huk
   6. Jonathan W Pillow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript tests an important assumption about how sensory information is processed and used to guide motor choices. The widely held assumption is that sensory-motor circuits are capable of integrating evidence, but the validity and generality of this 'principle' have been recently questioned by studies suggesting that other computational operations may lead to similar psychophysical results, mimicking integration without actually performing it. This study makes a compelling case that the integration assumption was likely correct all along and that the model mimicry can be easily disambiguated by using appropriate sensory stimuli and task designs that permit rigorous analyses.

   Reviewed by eLife

2. The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity

   This article has 2 authors:

   1. Rebecca Jordan
   2. Georg B Keller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides convincing evidence that locus coeruleus is activated during visuomotor mismatches. Gain of function optogenetic experiments complement this evidence and indicate that locus coeruleus could be involved in the learning process that enables visuomotor predictions. This study, therefore, sets the groundwork for the circuit dissection of predictive signals in the visual cortex. Loss-of-function experiments would strengthen the evidence of the involvement of locus coeruleus in prediction learning. These results will be of interest to systems neuroscientists.

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3. Coevolutionary dynamics via adaptive feedback in collective-risk social dilemma game

   This article has 3 authors:

   1. Linjie Liu
   2. Xiaojie Chen
   3. Attila Szolnoki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper provides a valuable, in-depth mathematical analysis of the coevolutionary dynamics resulting from a coupling of players' strategies and (collective) risk, as well as illustrative numerical simulations of the system's trajectories for different starting conditions. It is therefore a solid contribution to our understanding of how cooperation can be sustained when there is feedback between individual decisions and the global risk of disaster. This paper will be of interest to scientists working on mathematical biology/ecology, and more generally various aspects of human decision-making, the interplay between human decisions and the environment, and public goods provision.

   Reviewed by eLife

4. Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate

   This article has 10 authors:

   1. Farah Haddad
   2. Amro M Soliman
   3. Michael E Wong
   4. Emilie H Albers
   5. Shawna L Semple
   6. Débora Torrealba
   7. Ryan D Heimroth
   8. Asif Nashiry
   9. Keith B Tierney
   10. Daniel R Barreda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study addressed a long-standing question in biology - the role of fever during infections. Using innovative research strategy, the authors provide compelling evidence for the positive impact of higher body temperature on both pathogen clearance and tissue repair. This study thus provides important advances in our understanding of host defense and its connection with physiology and behavior.

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5. A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

   This article has 3 authors:

   1. Priscilla S-W Yeung
   2. Megumi Yamashita
   3. Murali Prakriya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports novel and important findings on the mechanisms of regulation of CRAC channels. Collectively, the work represents an important conceptual advancement, showing that stromal interaction molecule-1 is not necessary for Ca2+-dependent inactivation of the Orai1 channel and that Orai1 likely contains a Ca2+ sensor for autoregulatio. The experiments are carefully conducted, and the data is of high quality and support the major conclusions of the authors.

   Reviewed by eLife

6. Vernalization-triggered expression of the antisense transcript COOLAIR is mediated by CBF genes

   This article has 9 authors:

   1. Myeongjune Jeon
   2. Goowon Jeong
   3. Yupeng Yang
   4. Xiao Luo
   5. Daesong Jeong
   6. Jinseul Kyung
   7. Youbong Hyun
   8. Yuehui He
   9. Ilha Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper advances the understanding, in the model plant Arabidopsis thaliana, of the molecular basis of the promotion of flowering in the spring by exposure to winter cold through a process known as vernalization. In Arabidopsis, there are two classes of long non-coding RNAs produced only when plants are in the cold, and this work provides compelling evidence that the cold-induced expression of one of these (COOLAIR) involves C-repeat binding factor proteins that bind to cognate binding elements in the COOLAIR promoter, but also that COOLAIR is not required for the vernalization-mediated promotion of flowering under standard laboratory conditions in which the vernalization response is measured.

   Reviewed by eLife

7. Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma

   This article has 33 authors:

   1. Danni Cheng
   2. Ke Qiu
   3. Yufang Rao
   4. Minzi Mao
   5. Li Li
   6. Yan Wang
   7. Yao Song
   8. Junren Chen
   9. Xiaowei Yi
   10. Xiuli Shao
   11. Shao Hui Huang
   12. Yi Zhang
   13. Xuemei Chen
   14. Sisi Wu
   15. Shuaishuai Yu
   16. Jun Liu
   17. Haiyang Wang
   18. Xingchen Peng
   19. Daibo Li
   20. Lin Yang
   21. Li Chen
   22. Zhiye Ying
   23. Yongbo Zheng
   24. Meijun Zheng
   25. Binwu Ying
   26. Xiaoxi Zeng
   27. Wei Zhang
   28. Wei Xu
   29. Geoffrey Liu
   30. Fei Chen
   31. Haopeng Yu
   32. Yu Zhao
   33. Jianjun Ren

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides fundamental insight into the functional impact of CDK4 inhibition on cells in the tumor microenvironment, which is of high importance and interest to the field. The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. This work will be of interest to researchers across tumor types and in other immunological fields of study.

   Reviewed by eLife

8. A unified neural account of contextual and individual differences in altruism

   This article has 3 authors:

   1. Jie Hu
   2. Arkady Konovalov
   3. Christian C Ruff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of considerable interest to researchers studying the psychological and neural basis of variation in prosocial behavior. The authors use a sophisticated combination of computational modeling and EEG to show that variation in generosity produced by changes in context (i.e., disadvantageous vs. advantageous inequality) and variation due to individual differences in concern for others both seem to occur early, during the perceptual or valuation stage of a choice, rather than later on during choice comparison. However, these two sources of variation also appear to operate through distinct mechanisms during this stage of processing, which spurs further questions about the drivers of human prosocial behavior.

   Reviewed by eLife

9. Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

   This article has 7 authors:

   1. Aygul Subkhangulova
   2. Miguel A Gonzalez-Lozano
   3. Alexander JA Groffen
   4. Jan RT van Weering
   5. August B Smit
   6. Ruud F Toonen
   7. Matthijs Verhage

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors examine the function of Tomosyn, in dense core vesicle fusion in neuronal cultures from mice expressing conditional alleles of tomosyn and tomosyn-2. The authors show here that while loss of tomosyns did not affect dense core vesicle exocytosis, it reduced the expression of several key dense core cargos, including BDNF. However, "rescue" experiments are needed to validate the specificity of the effects.

   Reviewed by eLife

10. Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

    This article has 23 authors:

    1. Alexandra Polyák
    2. Leila Topal
    3. Noémi Zombori-Tóth
    4. Noémi Tóth
    5. János Prorok
    6. Zsófia Kohajda
    7. Szilvia Déri
    8. Vivien Demeter-Haludka
    9. Péter Hegyi
    10. Viktória Venglovecz
    11. Gergely Ágoston
    12. Zoltán Husti
    13. Péter Gazdag
    14. Jozefina Szlovák
    15. Tamás Árpádffy-Lovas
    16. Muhammad Naveed
    17. Annamária Sarusi
    18. Norbert Jost
    19. László Virág
    20. Norbert Nagy
    21. István Baczkó
    22. Attila S Farkas
    23. András Varró

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents valuable comprehensive data that underpin the enhanced ventricular arrhythmogenesis in elite trained athletes. The study is logistical challenge and the multiscale approaches used is a strength of the study. The data presented are strong and support most of the authors' claims.

    Reviewed by eLife