eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2023.04.04.535525

2. We couldn't get details of this article at this time:
   10.1101/2023.04.10.536254

3. Distinct hippocampal and cortical contributions in the representation of hierarchies

   This article has 3 authors:

   1. Robert Scholz
   2. Arno Villringer
   3. Mauricio J.D. Martins

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study investigates how hierarchies are processed in the brain, using a paradigm that intends to bridge disparate domains (e.g., language/music and memory). The main findings are that hippocampus and medial prefrontal cortex are sensitive to hierarchy position, while the response in inferior frontal gyrus seems to vary with amount of experience with the hierarchy. Evidence supporting these claims is solid, and would be strengthened by additional methodological clarifications (e.g., as to why the particular analyses are most appropriate for the research question) and further discussion of limitations related to the study design (e.g., the possibility that the task does not require hierarchical representations).

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2023.05.01.538969

5. An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

   This article has 9 authors:

   1. Tim Aguirre
   2. Gillian L Dornan
   3. Sarah Hostachy
   4. Martin Neuenschwander
   5. Carola Seyffarth
   6. Volker Haucke
   7. Anja Schütz
   8. Jens Peter von Kries
   9. Dorothea Fiedler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes a fundamental strategy for developing isozyme-selective inhibitors of inositol hexakisphosphate kinases. The compelling evidence that subtle changes to the gatekeeper position can sensitize the inositol hexakisphosphate kinase mutant to allosteric inhibitors will undoubtedly inspire other analog-sensitive inhibitor studies. This manuscript will be of interest to researchers focusing on kinase regulation and inhibitor design.

   Reviewed by eLife

6. N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

   This article has 5 authors:

   1. Anshuman Bhanja
   2. Margaret K Seeley-Fallen
   3. Michelle Lazzaro
   4. Arpita Upadhyaya
   5. Wenxia Song

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study highlighting a distinct role of WASP dependent actin foci in B cell antigen receptor signalling. The evidence supporting the conclusions is compelling. The proposal of higher molecular density in B cell receptor clustering leading to kinase exclusion and attenuated signalling is provocative as it contrasts with models for other antigen receptors.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2022.12.29.522277

8. TCR-pMHC complex formation triggers CD3 dynamics

   This article has 8 authors:

   1. Floris J. van Eerden
   2. Aalaa Alrahman Sherif
   3. Mara Anais Llamas-Covarrubias
   4. Arthur Millius
   5. Xiuyuan Lu
   6. Shigenari Ishizuka
   7. Sho Yamasaki
   8. Daron M. Standley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     There was a range of opinion among three highly expert reviewers from different perspectives in the field. This is a significant topic and it was felt that the contribution at present is valuable to those in the field. However, it was agreed after consultation that the description of the simulation methodology was inadequate.

   Reviewed by eLife

9. Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

   This article has 16 authors:

   1. Wenjie Xu
   2. Chenglong Zhu
   3. Xueli Gao
   4. Baosheng Wu
   5. Han Xu
   6. Mingliang Hu
   7. Honghui Zeng
   8. Xiaoni Gan
   9. Chenguang Feng
   10. Jiangmin Zheng
   11. Jing Bo
   12. Li-Sheng He
   13. Qiang Qiu
   14. Wen Wang
   15. Shunping He
   16. Kun Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of the potential mechanisms of deep-sea adaptation and sheds light on the evolutionary history of hadal snailfish. Through comparative genomic analysis, the authors provide convincing evidence and propose hypotheses on the timing of trench colonization, population structure, and adaptations to the hadal snailfish genome in response to their environment.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2023.03.16.532991