eLife

Latest preprint reviews

1. Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

   This article has 13 authors:

   1. Kieran A Boyle
   2. Erika Polgar
   3. Maria Gutierrez-Mecinas
   4. Allen C Dickie
   5. Andrew H Cooper
   6. Andrew M Bell
   7. Evelline Jumolea
   8. Adrian Casas-Benito
   9. Masahiko Watanabe
   10. David I Hughes
   11. Gregory A Weir
   12. John S Riddell
   13. Andrew J Todd

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Boyle et al identify Npy-expressing dorsal horn neurons as powerfully inhibiting pain and itch under normal and pathological conditions. The valuable data are convincing, and the effect sizes are robust and directly challenge previous work.

   Reviewed by eLife

2. Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

   This article has 4 authors:

   1. Cheng-Kuang Huang
   2. Xianbin Yong
   3. David T. She
   4. Chwee Teck Lim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents important findings into the response of epithelial monolayers to the combined effects of surface curvature and hydraulic stress, offering insights into how these cues contribute to epithelial cell extrusion. Most of the evidence is convincing, relying mainly on a combination of imaging-based techniques. This paper is of interest to a broad and growing community of biologists, biophysicists, and engineers interested in cell-geometry interactions.

   Reviewed by eLife

3. Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

   This article has 4 authors:

   1. Niklas Simon
   2. Abu Safyan
   3. George Pyrowolakis
   4. Shinya Matsuda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses genomically-engineered glypican alleles (Dally and Dally-like) to determine the role of these proteins on the Dpp/BMP morphogen gradient in the wing disc of Drosophila melanogaster. The new glypican null and tagged add-back alleles, as well as a Dpp mutant that cannot bind heparin sulfate moieties in glypicans, provide solid results that support the model in which Dally but not Dally-like stabilizes Dpp on the cell surface by counteracting receptor-mediated Dpp internalization. This paper would be of interest to developmental biologists working on morphogens.

   Reviewed by eLife

4. An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo

   This article has 24 authors:

   1. Luyang Cao
   2. Lixiang Ma
   3. Juan Zhao
   4. Xiangyu Wang
   5. Xinzou Fang
   6. Wei Li
   7. Yawen Qi
   8. Yingkui Tang
   9. Jieya Liu
   10. Shengxian Peng
   11. Li Yang
   12. Liangxue Zhou
   13. Li Li
   14. Xiaobo Hu
   15. Yuan Ji
   16. Yingyong Hou
   17. Yi Zhao
   18. Xianming Zhang
   19. You-yang Zhao
   20. Yong Zhao
   21. Yuquan Wei
   22. Asrar B Malik
   23. Hexige Saiyin
   24. Jingsong Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports the fundamental discovery of a new function of neutrophil in specifically clearing apoptotic hepatocytes by penetrating the cells rather than engulfing them without causing inflammation as a part of tissue homeostasis. This solid study transforms the way we think about role of neutrophil in pathogenesis of autoimmune liver disease.

   Reviewed by eLife

5. Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

   This article has 10 authors:

   1. David J Torres
   2. Paulus Mrass
   3. Janie Byrum
   4. Arrick Gonzales
   5. Dominick N Martinez
   6. Evelyn Juarez
   7. Emily Thompson
   8. Vaiva Vezys
   9. Melanie E Moses
   10. Judy L Cannon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study that quantifies CD8 T cell movement in different tissue environments and concludes that T cells display more confined movement in the inflamed lung than in lymph nodes or intestinal villi. The evidence supporting conclusions is solid with well-defined measurements and sufficient statistical analysis. The work will stimulate further efforts to understand the mechanisms behind the different behaviour of T cells that are important in host defence against intracellular pathogens and cancer.

   Reviewed by eLife

6. A framework for community curation of interspecies interactions literature

   This article has 6 authors:

   1. Alayne Cuzick
   2. James Seager
   3. Valerie Wood
   4. Martin Urban
   5. Kim Rutherford
   6. Kim E Hammond-Kosack

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study reports improvements in methods and tools for curating complex pathogen-host interactions. A compelling framework is described, using rigorous approaches and to considerable extent validated by the biocuration community. The developed ontologies and controlled vocabularies could be extended beyond host pathogens, e.g. ecological contexts with multi-species and multilevel interactions.

   Reviewed by eLife

7. Psychological Resilience in Adolescence as a function of Genetic Risk for Major Depressive Disorder and Alzheimer’s Disease

   This article has 2 authors:

   1. Raluca Petrican
   2. Alex Fornito

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents a multimodal approach to ascertain links between risk and resilience to depression and Alzheimer's disease in a large pediatric sample. The authors find two latent imaging variables that may be associated with resilience to adverse life events and disease risk, which show some spatial overlap with disease relevant gene-expression patterns and neurotransmitter expression. Such findings could be important for understanding mechanisms underlying resilience in neurological disorders, however, the analyses are inadequate for fully supporting the interpretation of the variables involved in these models, or for supporting some of the overall conclusions of the work.

   Reviewed by eLife

8. Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

   This article has 20 authors:

   1. Edmée Eyraud
   2. Elise Maurat
   3. Jean-Marc Sac-Epée
   4. Pauline Henrot
   5. Maeva Zysman
   6. Pauline Esteves
   7. Thomas Trian
   8. Jean-William Dupuy
   9. Alexander Leipold
   10. Antoine-Emmanuel Saliba
   11. Hugues Begueret
   12. Pierre-Olivier Girodet
   13. Matthieu Thumerel
   14. Romain Hustache-Castaing
   15. Roger Marthan
   16. Florian Levet
   17. Pierre Vallois
   18. Cécile Contin-Bordes
   19. Patrick Berger
   20. Isabelle Dupin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript by Eyraud and colleagues examines the role of interactions between fibrocytes and CD8 cells as drivers of disease progression in COPD (chronic obstructive pulmonary disease). The findings that there exist bidirectional interactions between CD8 cells and fibrocytes are supported by solid evidence that combines histology of clinical lung samples, in vitro studies obtained from circulating blood fibrocytes and CD8 cells, as well as a computational model that predicts how bidirectional interactions could promote disease progression over the course of 20 years. The study, which is based on patient samples, thus provides fundamental insights on COPD progression.

   Reviewed by eLife

9. Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

   This article has 15 authors:

   1. Giuseppina Mastrototaro
   2. Pierluigi Carullo
   3. Jianlin Zhang
   4. Beatrice Scellini
   5. Nicoletta Piroddi
   6. Simona Nemska
   7. Maria Carmela Filomena
   8. Simone Serio
   9. Carol A Otey
   10. Chiara Tesi
   11. Fabian Emrich
   12. Wolfgang A Linke
   13. Corrado Poggesi
   14. Simona Boncompagni
   15. Marie-Louise Bang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will be of interest to scientists who study cardiomyocyte homeostasis and contraction. It assesses the functional consequences of cardiomyocyte-specific knockout of Palladin, leading to the identification of a compensation mechanism when Palladin is deleted in embryogenesis, but not in adulthood. In addition, the authors identified new Palladin interactors, revealing a role for Palladin in the maintenance of intercalated disc structure.

   Reviewed by eLife

10. Metabolic consequences of various fruit-based diets in a generalist insect species

    This article has 7 authors:

    1. Laure Olazcuaga
    2. Raymonde Baltenweck
    3. Nicolas Leménager
    4. Alessandra Maia-Grondard
    5. Patricia Claudel
    6. Philippe Hugueney
    7. Julien Foucaud

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This useful study uses untargeted metabolomics to help us understand how some herbivores are able to be generalists, rather than specializing in the metabolism of specific plant species. This is an important area, since little is known about how generalist insect species metabolize their food. In its current form, the study lacks ecological relevance due to the exclusive use of refined sampling procedures, and the metabolomic analysis is incomplete.

    Reviewed by eLife