eLife

Latest preprint reviews

1. Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

   This article has 12 authors:

   1. Robbin A. Nameki
   2. Heidi Chang
   3. Pak Yu
   4. Forough Abbasi
   5. Xianzhi Lin
   6. Jessica Reddy
   7. Marcela Haro
   8. Marcos AS Fonseca
   9. Matthew L. Freedman
   10. Ronny Drapkin
   11. Rosario I. Corona
   12. Kate Lawrenson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study has successfully identified four key transcription factors (MECOM, PAX8, SOX17, and WT1) that exhibit synergistic effects and are potentially responsible for the transformation of fallopian tube secretory epithelial cells into high-grade serous 'ovarian' cancer cells. Convincing data strongly support the drawn conclusion and significantly contribute to our understanding of the etiology of this devastating cancer. The implications of this finding are substantial, as it provides molecular insights that can potentially pave the way for innovative diagnostics and therapeutics in the field of gynecological oncology. Enhancing the clarity and impact of this study would be achieved through improvements in data presentation.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.04.24.538182

3. Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period

   This article has 14 authors:

   1. David Bolumar
   2. Javier Moncayo-Arlandi
   3. Javier Gonzalez-Fernandez
   4. Ana Ochando
   5. Inmaculada Moreno
   6. Ana Monteagudo-Sanchez
   7. Carlos Marin
   8. Antonio Diez
   9. Paula Fabra
   10. Miguel Angel Checa
   11. Juan Jose Espinos
   12. David K Gardner
   13. Carlos Simon
   14. Felipe Vilella

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports important results on the potential influence of maternally derived extracellular vesicles on embryo metabolism. The study combines convincing techniques for isolating different subtypes of EV, DNA sequencing, embryo culture, and respiration assays performed on human endometrial samples and mouse embryos. These findings set the stage for in-depth studies to elucidate the role of EV contents in embryo energetics and further enhance our understanding on maternal-fetal communication during peri-implantation development.

   Reviewed by eLife

4. Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

   This article has 11 authors:

   1. Huan Wang
   2. Syed RA Rizvi
   3. Danni Dong
   4. Jiaqi Lou
   5. Qian Wang
   6. Watanyoo Sopipong
   7. Yufeng Su
   8. Fares Najar
   9. Pratul K Agarwal
   10. Frank Kozielski
   11. Shozeb Haider

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important discovery that the RNA synthesis protein of SARS-CoV-2, the virus that is responsible for COVID 19, has fewer mutations and causes limited conformational changes. The evidence supporting the claims is convincing, with robust sequence alignment studies, state-of-the-art protein-protein interaction analysis, and molecular conformational analysis. This work has implications for drug design and will be of broad interest to the general biophysics and structural biology community.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.03.07.531554

6. Nuclear bodies protect phase separated proteins from degradation in stressed proteome

   This article has 6 authors:

   1. Kwan Ho Jung
   2. Jiarui Sun
   3. Chia-Heng Hsiung
   4. Xiaojun Lance Lian
   5. Yu Liu
   6. Xin Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a novel fluorescence based imaging strategy to investigate the folding status of RNA-binding proteins (RBPs) and their association with molecular chaperones under stress. It provides fundamental findings that will potentially advance our understanding in the folding and aggregation status of RBPs in nuclear stress bodies in a significant manner. However, there is also the concern that the evidence regarding protein fate is incomplete and additional controls are needed to fully support the conclusion. The imaging methodology can be adapted to study many other proteins that undergo liquid-liquid phase separation under specific cellular conditions.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.03.08.531789

8. High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope

   This article has 7 authors:

   1. Swati Tyagi
   2. Juliana S. Capitanio
   3. Jiawei Xu
   4. Fei Chen
   5. Rahul Sharma
   6. Jialiang Huang
   7. Martin W. Hetzer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes important findings that will impact our understanding of nuclear pore complex (NPC)-genome interactions and how nuclear pore proteins (nucleoporins) impact super enhancer function. The authors develop a clever new approach termed NPC-DamID to map chromatin-NPC interactions that has several important advantages over existing techniques and may be used in contexts that are incompatible with genetic manipulation. The authors provide compelling evidence that nucleoporins interact with super enhancers in multiple cell types and also suggest that the phase separation behavior of nucleoporins contributes to the hierarchical organization of super enhancers, which is exciting and will stimulate additional work.

   Reviewed by eLife

9. Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency

   This article has 16 authors:

   1. Léa Broca-Brisson
   2. Rania Harati
   3. Clémence Disdier
   4. Orsolya Mozner
   5. Romane Gaston-Breton
   6. Auriane Maïza
   7. Narciso Costa
   8. Anne-Cécile Guyot
   9. Balazs Sarkadi
   10. Agota Apati
   11. Matthew R Skelton
   12. Lucie Madrange
   13. Frank Yates
   14. Jean Armengaud
   15. Rifat Hamoudi
   16. Aloïse Mabondzo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study highlighting how a single protein transporter dysfunction can significantly alter brain biochemistry, potentially playing a crucial role in the intellectual disability in creatine transporter deficiency (CTD) patients. The evidence is compelling that the new in vitro CTD model using CTD patient's brain organoid cultures will be widely applicable. Despite minor areas for further exploration, the study significantly enhances our understanding of CTD, offering potential therapeutic targets and a robust foundation for continued research in the field.

   Reviewed by eLife

10. Thalamic regulation of ocular dominance plasticity in adult visual cortex

    This article has 7 authors:

    1. Yi Qin
    2. Mehran Ahmadlou
    3. Samuel Suhai
    4. Paul Neering
    5. Leander de Kraker
    6. J Alexander Heimel
    7. Christiaan N Levelt

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study demonstrates that plasticity of ocular dominance of binocular neurons in the visual thalamus persists in adulthood. The evidence supporting the authors' conclusion is convincing, and the findings are an important contribution to a growing body of work identifying plasticity in the adult visual system. This work will interest those in the field of ocular dominance plasticity in the visual system as well as scientists investigating the function of synaptic plasticity in the brain.

    Reviewed by eLife