eLife

Latest preprint reviews

1. Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans

   This article has 13 authors:

   1. Taylor N Medwig-Kinney
   2. Brian A Kinney
   3. Michael AQ Martinez
   4. Callista Yee
   5. Sydney S Sirota
   6. Angelina A Mullarkey
   7. Neha Somineni
   8. Justin Hippler
   9. Wan Zhang
   10. Kang Shen
   11. Christopher Hammell
   12. Ariel M Pani
   13. David Q Matus

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. While the observation that NHR-67 forms punctae associated with transcriptional repressors in non-invasive cells is intriguing, the work does not yet established a clear link between the formation and dissolution of NHR-67 condensates with the activation of downstream genes that NHR-67 is actively repressing. The work will be of interest to developmental biologists studying transcriptional control of cell fate specification in animals, especially once issues around the functional significance of the NHR-67 contiaining punctae are resolved.

   Reviewed by eLife

2. De Novo Multi-Omics Pathway Analysis Designed for Prior Data Independent Inference of Cell Signaling Pathways

   This article has 4 authors:

   1. Katri Vaparanta
   2. Johannes A.M. Merilahti
   3. Veera K. Ojala
   4. Klaus Elenius

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This manuscript describes development of a new algorithm for integrative analysis of multi-omics data. This work should be of potential interest to scientists performing bioinformatic pathway discovery in multi-omic datasets especially those that relate to signaling.

   Reviewed by eLife

3. The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

   This article has 9 authors:

   1. Hugo Siegfried
   2. Georges Farkouh
   3. Rémi Le Borgne
   4. Catherine Pioche-Durieu
   5. Thaïs De Azevedo Laplace
   6. Agathe Verraes
   7. Lucien Daunas
   8. Jean-Marc Verbavatz
   9. Mélina L Heuzé

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents valuable findings that bring together two important topics in cell biology: the function of membrane contact sites and cell migration. The authors describe a role of the ER tether protein VAP-A in focal adhesion dynamics and cell motility. Although the authors present solid evidence to support some of the main claims of the paper, some of the other claims would benefit from stronger experimental support. Nonetheless, this paper will be of interest to those cell biologists and biophysicists working on adhesion, migration, and membrane contact site biology.

   Reviewed by eLife

4. Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

   This article has 10 authors:

   1. Kazuki Inoue
   2. Yongli Qin
   3. Yuhan Xia
   4. Jie Han
   5. Ruoxi Yuan
   6. Jun Sun
   7. Ren Xu
   8. Jean X Jiang
   9. Matthew B Greenblatt
   10. Baohong Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of interest for skeletal biologists studying bone marrow stem/progenitor cells and bone remodeling. Using Adipoq-Cre-driven conditional deletion of Csf1 that encodes M-CSF and reanalyzing publicly available scRNAseq data, the authors recognize a subpopulation of bone marrow cells (i.e. AdipoQ-lineage progenitors) as an important source of M-CSF. The authors found that M-CSF production from these bone marrow cells influences the development of macrophages and osteoclasts as well as bone mass, including the bone loss associated with estrogen deficiency. This is a clearly written and nicely presented study that has potential to offer important new information regarding the source of M-CSF in the bone marrow.

   Reviewed by eLife

5. Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19

   This article has 11 authors:

   1. The COVID Tissue Atlas Consortium
   2. Alejandro A Granados
   3. Simon Bucher
   4. Hanbing Song
   5. Aditi Agrawal
   6. Ann T Chen
   7. Tien Peng
   8. Norma Neff
   9. Angela Oliveira Pisco
   10. Franklin Huang
   11. Bruce Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a valuable data resource to study the systemic effects of severe COVID-19. It shows compelling evidence that the transcriptional response to COVID-19 is coordinated across the body, and it highlights cell interactions between macrophages and endothelial cells in COVID-19. This analysis and the associated resource will be valuable to understand the pathogenic mechanism of long-COVID.

   Reviewed by eLife, ScreenIT

6. Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging

   This article has 4 authors:

   1. Kevin Yueh Lin Ho
   2. Rosalyn Leigh Carr
   3. Alexandra Dmitria Dvoskin
   4. Guy Tanentzapf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study develops a new technical advancement in ex vivo live imaging of hematopoietic tissues to monitor blood cells in their native microenvironment. The new method for live imaging and tracking is compelling, and the strength and breadth of hematopoietic analysis are convincing. This work provides a very useful new system for immunologists and cell biologists, which will supply new perspectives on the system-level mechanisms of cell differentiation and innate immunity.

   Reviewed by eLife

7. ATRAP - Accurate T cell Receptor Antigen Pairing through data-driven filtering of sequencing information from single-cells

   This article has 6 authors:

   1. Helle Rus Povlsen
   2. Amalie Kai Bentzen
   3. Mohammad Kadivar
   4. Leon Eyrich Jessen
   5. Sine Reker Hadrup
   6. Morten Nielsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of interest to immunologists conducting single-cell analyses of T-cell recognition. It provides a means of curating datasets to ensure T cell-antigen pairs are identified. The data generated through this method often suffers from a relatively high background, so the authors present a computational approach to enhance the signal-to-noise of this type of analysis. At this stage, it is unclear if the thresholds and filtering steps described by the authors can be generally applied to other datasets of different qualities than the one used here.

   Reviewed by eLife

8. Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles

   This article has 2 authors:

   1. Jason T George
   2. Herbert Levine

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable mathematical model for the adaptive dynamics of cancer evolution in response to immune recognition. The mathematical analysis is rigorous and convincing, and overall the framework presented could be used in the future as a solid base for analytically tracking tumor evasion strategies. However additional discussion is needed to clarify certain gaps between the theory and cancer evolution in real systems. The work will be of interest to evolutionary cancer biologists and potentially it may also have implications for the design of clinical interventions.

   Reviewed by eLife

9. The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

   This article has 16 authors:

   1. Chi Zhang
   2. Xianfu Yi
   3. Mengfan Hou
   4. Qingyang Li
   5. Xueying Li
   6. Lu Lu
   7. Enlin Qi
   8. Mingxin Wu
   9. Lin Qi
   10. Huan Jian
   11. Zhangyang Qi
   12. Yigang Lv
   13. Xiaohong Kong
   14. Mingjun Bi
   15. Shiqing Feng
   16. Hengxing Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the critical features and patterns of m1A modification and in neurons and OGD/R-treated neurons. Moreover, the authors identified m1A modifications on different RNAs and explored the possible effects of m1A modification on the functions of different RNAs via an integrated approach of omics and bioinformatics. The evidence supporting the claims of the authors is solid, although inclusion of more in-depth studies to analyze the transcription factors for the upstream regulation would have strengthened the study. The work will be of interest to neurobiologist and scientists in the field of RNAs.

   Reviewed by eLife

10. Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila

    This article has 14 authors:

    1. Hilary Scott
    2. Boris Novikov
    3. Berrak Ugur
    4. Brooke Allen
    5. Ilya Mertsalov
    6. Pedro Monagas-Valentin
    7. Melissa Koff
    8. Sarah Baas Robinson
    9. Kazuhiro Aoki
    10. Raisa Veizaj
    11. Dirk J Lefeber
    12. Michael Tiemeyer
    13. Hugo Bellen
    14. Vladislav Panin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Scott et al use Drosophila as a model to study the sialylation pathway and its role in nervous system function. Surprisingly, they find that the critical substrate for sialylation, CMP-Neu5Ac, is 'outsourced' to glia. This significant study presents a new twist in mechanisms underlying protein glycosylation and uncovers a new layer in the complex interplay of neurons and glia.

    Reviewed by eLife