eLife

Latest preprint reviews

1. Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

   This article has 24 authors:

   1. Ali Reza Ahmadi
   2. Guang Song
   3. Tianshun Gao
   4. Jing Ma
   5. Xiaomei Han
   6. Ming-Wen Hu
   7. Andrew M Cameron
   8. Russell N Wesson
   9. Benjamin Philosophe
   10. Shane Ottmann
   11. Elizabeth King
   12. Ahmet Gurakar
   13. Le Qi
   14. Brandon Peiffer
   15. James Burdick
   16. Robert Anders
   17. Zhanxiang Zhou
   18. Hongkun Lu
   19. Dechun Feng
   20. Chien-Sheng Chen
   21. Jiang Qian
   22. Bin Gao
   23. Heng Zhu
   24. Zhaoli Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study tested the hypothesis that liver-derived but not serum-derived antibodies that are cross-reactive to E.coli and to host proteins can play a role in the hepatic damage found in severe alcoholic hepatitis (SAH). Using a solid methodology that includes state-of-the-art microscopy, proteome arrays, and gene ontology assays, it provides strong evidence that liver-derived IgG and IgA with cytotoxic properties and reactivity to both gut-derived E.coli and autoantigens accumulated in hepatocytes of SAH patients but not of healthy controls. The study would benefit from a broader analysis of gut microbiota proteome and further characterization of B cells infiltrating the liver tissue including their numbers/field and their origin (infiltrating versus resident cells). The work opens new avenues of understanding for the pathogenesis of severe alcoholic hepatitis and is of great interest to researchers and clinicians in the field.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.05.25.542290

3. We couldn't get details of this article at this time:
   10.1101/2023.03.06.530447

4. We couldn't get details of this article at this time:
   10.1101/2022.02.04.479188

5. Effort cost of harvest affects decisions and movement vigor of marmosets during foraging

   This article has 8 authors:

   1. Paul Hage
   2. In Kyu Jang
   3. Vivian Looi
   4. Mohammad Amin Fakharian
   5. Simon P Orozco
   6. Jay S Pi
   7. Ehsan Sedaghat-Nejad
   8. Reza Shadmehr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study unravels the interaction between effort cost, pupil-indexed brain state, and movement (saccadic) vigor during foraging decisions in marmoset monkeys. Based on a normative computational model, the authors derive the prediction that anticipated effort should affect both decisions and movement vigor during foraging; and then provide solid behavioural and pupillometric evidence for this prediction in a foraging task. This paper will be of interest to decision and motor neuroscience as well as to all researchers studying animal behavior.

   Reviewed by eLife

6. Molecular tuning of sea anemone stinging

   This article has 8 authors:

   1. Lily S He
   2. Yujia Qi
   3. Corey AH Allard
   4. Wendy A Valencia-Montoya
   5. Stephanie P Krueger
   6. Keiko Weir
   7. Agnese Seminara
   8. Nicholas W Bellono

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important paper that links distinctive stinging behavior of two related anemones occupying different ecological niches to varying inactivation properties of voltage-gated calcium channels conferred by auxiliary Cavβ subunits. Further convincing evidence is provided that these differences are mediated by alternative splicing of Cavβ subunit of the calcium channel. The study will be of interest to scientists studying Ca2+ signaling, ion channel biophysicists, and marine biologists.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.05.19.541437

8. We couldn't get details of this article at this time:
   10.1101/2023.01.04.522718

9. Free energy landscapes of KcsA inactivation

   This article has 2 authors:

   1. Sergio Pérez-Conesa
   2. Lucie Delemotte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, advanced simulation methodologies are used to extract the mechanisms of inactivation for the potassium ion channel KcsA. The string method approach provides solid evidence that reveal features associated with the interplay between gate size and collapse of the selectivity filter, as well as remarkable differences between different force fields. While this manuscript does not address recent discoveries in K channel inactivation involving dilated selectivity filter structures obtained by Xray and cryo-EM, it does help us understand the KcsA constriction process. With added descriptions and analysis of collective variables, improved reproducibility of results, consistency between string method free energies and unbiased simulations, and improved transition rate calculation, this manuscript will be of interest to the ion channel field.

   Reviewed by eLife

10. Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

    This article has 8 authors:

    1. Marco Leibinger
    2. Charlotte Zeitler
    3. Miriam Paulat
    4. Philipp Gobrecht
    5. Alexander Hilla
    6. Anastasia Andreadaki
    7. Rainer Guthoff
    8. Dietmar Fischer

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The primary goal of this paper is to examine microtubule detyrosination as a potential therapeutic target for axon regeneration. The valuable findings of this study provide convincing evidence for mechanistic links between microtubule detyrosination and neurite outgrowth in vitro and some evidence for axon regeneration in vivo.

    Reviewed by eLife