eLife

Latest preprint reviews

1. CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

   This article has 10 authors:

   1. Iva Lučić
   2. Léonie Héluin
   3. Pin-Lian Jiang
   4. Alejandro G Castro Scalise
   5. Cong Wang
   6. Andreas Franz
   7. Florian Heyd
   8. Markus C Wahl
   9. Fan Liu
   10. Andrew JR Plested

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports the fundamental finding that an oligomeric protein kinase, CaMKII, can be phosphorylated by another molecule of the holoenzyme in a manner that does not involve subunit exchange. The evidence for the main conclusion is compelling, supported by several independent experiments. If independently confirmed in future, the study will stand as having provided a novel regulatory mechanism for the autophosphorylation of this kinase. The work will be of broad interest to molecular and cellular neuroscientists as well as biochemists.

   Reviewed by eLife

2. Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

   This article has 5 authors:

   1. Ann-Kathrin Joechner
   2. Michael A Hahn
   3. Georg Gruber
   4. Kerstin Hoedlmoser
   5. Markus Werkle-Bergner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important analysis of two sleep datasets in children and adolescents that contributes to our understanding of sleep spindle and slow oscillation dynamics during development and is expected to be of interest to interdisciplinary fields including development and sleep. The analyses are solid and adequately complex to capture the changes in sleep spindle to slow oscillation coupling between the age groups. However, the paper would be strengthened by performing the same analyses in an adult sample to sufficiently characterize the maturation of sleep spindles and their coupling to slow oscillations.

   Reviewed by eLife

3. Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study

   This article has 8 authors:

   1. Xiaohao Ruan
   2. Da Huang
   3. Yongle Zhan
   4. Jingyi Huang
   5. Jinlun Huang
   6. Ada Tsui-Lin Ng
   7. James Hok-Leung Tsu
   8. Rong Na

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the associations and causal relationship between second primary cancers and the initial diagnosis of a primary cancer via using a large database. The evidence supporting the claims of the authors is solid. The work will be of interest to cancer clinicians.

   Reviewed by eLife

4. Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy

   This article has 10 authors:

   1. Haoyan Huang
   2. Meng Qian
   3. Yue Liu
   4. Shang Chen
   5. Huifang Li
   6. Zhibo Han
   7. Zhong-Chao Han
   8. Xiang-Mei Chen
   9. Qiang Zhao
   10. Zongjin Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines engineered mesenchymal stem cells together with mouse models of kidney injury to determine the ability of these cells to reduce kidney damage upon acute kidney injury. The evidence supporting the claims is solid, although the inclusion of more than one type of stem cell and the use of male mice which are more prone to acute kidney injury, would strengthen the study. This work will be of interest to both basic scientists and clinicians working on mechanisms of kidney injury and repair.

   Reviewed by eLife

5. A class-specific effect of dysmyelination on the excitability of hippocampal interneurons

   This article has 7 authors:

   1. Delphine Pinatel
   2. Edouard Pearlstein
   3. Giulia Bonetto
   4. Laurence Goutebroze
   5. Domna Karagogeos
   6. Valérie Crepel
   7. Catherine Faivre-Sarrailh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies the functional consequence of myelination of interneuronal axons on circuit function by showing that 4.1B deletion leads to altered myelination in a subset of interneurons and altered intrinsic and synaptic physiological parameters. The authors' conclusions about how myelination of inhibitory axons affects physiological properties are based on solid evidence using a combination of imaging and electrophysiological approaches.

   Reviewed by eLife

6. Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer

   This article has 7 authors:

   1. Robert A Phillips
   2. Ethan Wan
   3. Jennifer J Tuscher
   4. David Reid
   5. Olivia R Drake
   6. Lara Ianov
   7. Jeremy J Day

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that uses chromatin accessibility as a measure to determine the impact of neuronal activity on the state of chromatin regulatory elements in striatal neurons. The authors provide convincing evidence of how Pdyn gene expression is highly dependent on a distal regulatory genomic region both at basal and upon neuronal activation in this particular system, a mechanism conserved as well in human neuronal cells. Although the basic idea of accessibility changes have been studied before, this paper ties previous findings all together in one place and uses the analysis to identify a functionally relevant and conserved enhancer for the prodynorphin gene with potential relevance for neuropsychiatric disorders beyond basic cellular neuroscience. The study will be of interest to neuroscientists studying the striatum, neuronal plasticity, or related neuropsychiatric disorders.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.06.28.546967

8. BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI

   This article has 20 authors:

   1. Alena U. Uus
   2. Vanessa Kyriakopoulou
   3. Antonios Makropoulos
   4. Abi Fukami-Gartner
   5. Daniel Cromb
   6. Alice Davidson
   7. Lucilio Cordero-Grande
   8. Anthony N. Price
   9. Irina Grigorescu
   10. Logan Z. J. Williams
   11. Emma C. Robinson
   12. David Lloyd
   13. Kuberan Pushparajah
   14. Lisa Story
   15. Jana Hutter
   16. Serena J. Counsell
   17. A. David Edwards
   18. Mary A. Rutherford
   19. Joseph V. Hajnal
   20. Maria Deprez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study proposes a deep learning-based segmentation pipeline of fetal brain MRI, with parcellation based on a newly implemented atlas. This represents an important contribution to the field of developmental neuroscience and pediatric neuroimaging, especially as the pipeline and atlas are publicly available. The evidence for the pipeline robustness and atlas relevance is convincing given the extensive validations provided and the very high-quality ground truth dataset. Although beyond the state of the art, the study would benefit from further comparisons with existing methods and additional evaluations of the framework generalizability according to image quality, subject age or brain abnormalities.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.03.22.533836

10. Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    This article has 18 authors:

    1. Subhash Kulkarni
    2. Monalee Saha
    3. Jared Slosberg
    4. Alpana Singh
    5. Sushma Nagaraj
    6. Laren Becker
    7. Chengxiu Zhang
    8. Alicia Bukowski
    9. Zhuolun Wang
    10. Guosheng Liu
    11. Jenna M Leser
    12. Mithra Kumar
    13. Shriya Bakhshi
    14. Matthew J Anderson
    15. Mark Lewandoski
    16. Elizabeth Vincent
    17. Loyal A Goff
    18. Pankaj Jay Pasricha

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper identifies a subset of neurons within adult mouse myenteric ganglia that are not labeled via canonical neural-crest labeling, and argues, based on extensive lineage tracing, imaging and genomic data that these neurons are derived from mesoderm. There is convincing evidence for the existence of an unusual cell type in the gut that expresses neuronal markers, but which is derived from cells expressing markers of the mesoderm rather than the expected neural crest, which is an intriguing and important observation. While the data do not definitively establish the molecular taxonomy of this lineage, there is sufficient evidence to support the provocative and paradigm-shifting hypothesis of the non-ectodermal origin for enteric neurons to warrant further deeper investigation.

    Reviewed by eLife