eLife

Latest preprint reviews

1. Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

   This article has 3 authors:

   1. Hiroshi Yamaguchi
   2. Motohiro Morikawa
   3. Masahide Kikkawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In vertebrates, ciliary motility is powered by axonemal dyneins, known as OADs, tethered to doublet microtubules by a pentameric docking complex including the Armc4 and Calaxin subunits. This valuable study combines zebrafish genetics with cryo-electron tomography to convincingly show that Armc4 plays a critical role in the docking of OAD and that Calaxin stabilizes the molecular interaction. The work will be of interest to those studying the structure and function of the axoneme, and motile cilia in general.

   Reviewed by eLife

2. Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

   This article has 7 authors:

   1. Milena Rmus
   2. Mingjian He
   3. Beth Baribault
   4. Edward G Walsh
   5. Elena K Festa
   6. Anne GE Collins
   7. Matthew R Nassar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines behavior, computational modelling and magnetic resonance spectroscopy to address the question whether age-related declines in learning are driven by declines in working memory or deficiencies of the RL system. The general approach is solid, but the presented evidence to support the papers' main claims could be stronger. With additional analyses and adaptation of the main claims, the paper could be of high interest for researchers in the field of cognitive aging and decision making.

   Reviewed by eLife

3. Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

   This article has 18 authors:

   1. Yaeko Nakajima-Takagi
   2. Motohiko Oshima
   3. Junichiro Takano
   4. Shuhei Koide
   5. Naoki Itokawa
   6. Shun Uemura
   7. Masayuki Yamashita
   8. Shohei Andoh
   9. Kazumasa Aoyama
   10. Yusuke Isshiki
   11. Daisuke Shinoda
   12. Atsunori Saraya
   13. Fumio Arai
   14. Kiyoshi Yamaguchi
   15. Yoichi Furukawa
   16. Haruhiko Koseki
   17. Tomokatsu Ikawa
   18. Atsushi Iwama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present a manuscript aiming to understand the mechanism(s) underlying myeloid bias in HSCs, specifically focused on the role of Pcgf1, and therefore PRC1.1, in the regulation of hematopoiesis. This important work is of interest to the community of researchers interested in myeloid differentiation, lineage fate decisions in hematopoietic stem cells, and the molecular mechanisms that contribute to the initiation of myeloid malignancies. The methods are rigorous and the results convincingly support the authors' conclusions.

   Reviewed by eLife

4. Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

   This article has 4 authors:

   1. Adedeji M Aderounmu
   2. P Joseph Aruscavage
   3. Bryan Kolaczkowski
   4. Brenda L Bass

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable paper describing an attempt to reconstruct the evolution of Dicer. Using ancestral reconstruction approaches, the authors carefully examine the biochemical characteristics of reconstructed proteins at various junction points in the animal lineage. They provide solid evidence that the deepest ancestrally reconstructed protein has double-stranded RNA stimulated ATPase activity and that this characteristic was lost along the vertebrate lineage. This paper will be of interest to scientists in the RNA-protein interaction and protein evolution fields.

   Reviewed by eLife

5. VO2max prediction based on submaximal cardiorespiratory relationships and body composition in male runners and cyclists: a population study

   This article has 7 authors:

   1. Szczepan Wiecha
   2. Przemysław Seweryn Kasiak
   3. Piotr Szwed
   4. Tomasz Kowalski
   5. Igor Cieśliński
   6. Marek Postuła
   7. Andrzej Klusiewicz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors have established new formulas to predict maximum oxygen uptake for cyclists and runners based on submaximal exercise testing and anthropometric characteristics. This is an important study with a large and comprehensive dataset, which may be helpful for many exercise labs. The work is convincing, using appropriate and validated methodology in line with the current state-of-the-art, as shown by references to common exercise books.

   Reviewed by eLife

6. Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

   This article has 12 authors:

   1. Pedro P Cunha
   2. Eleanor Minogue
   3. Lena CM Krause
   4. Rita M Hess
   5. David Bargiela
   6. Brennan J Wadsworth
   7. Laura Barbieri
   8. Carolin Brombach
   9. Iosifina P Foskolou
   10. Ivan Bogeski
   11. Pedro Velica
   12. Randall S Johnson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In the current manuscript, the authors study the effects of hypoxia or genetic and pharmacologic modulation of the hypoxic pathways on T cells. The findings about T cells sense hypoxia and how hypoxia affects T cell (and CAR T cell) differentiation and function are significant and interesting for the field. The data supporting these findings are mostly robust, yet some questions remain open and some statements seem unsupported by evidence.

   Reviewed by eLife

7. Regulation of chromatin microphase separation by binding of protein complexes

   This article has 5 authors:

   1. Omar Adame-Arana
   2. Gaurav Bajpai
   3. Dana Lorber
   4. Talila Volk
   5. Samuel Safran

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work substantially advances our understanding of polymer physics underpinnings of genome folding, organization, and regulation. The conclusions are supported by both convincing computer simulations and analytical theory. The work will be of significant interest to the genome folding community.

   Reviewed by eLife

8. Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

   This article has 25 authors:

   1. Emmeline Marchal-Duval
   2. Méline Homps-Legrand
   3. Antoine Froidure
   4. Madeleine Jaillet
   5. Mada Ghanem
   6. Deneuville Lou
   7. Aurélien Justet
   8. Arnaud Maurac
   9. Aurelie Vadel
   10. Emilie Fortas
   11. Aurelie Cazes
   12. Audrey Joannes
   13. Laura Giersh
   14. Herve Mal
   15. Pierre Mordant
   16. Tristan Piolot
   17. Marin Truchin
   18. Carine M Mounier
   19. Ksenija Schirduan
   20. Martina Korfei
   21. Andreas Gunther
   22. Bernard Mari
   23. Frank Jaschinski
   24. Bruno Crestani
   25. Arnaud A Mailleux

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will be of interest to scientists in the field of tissue injury and repair. It provides novel molecular mechanisms of a transcription factor, Prrx1, in fibroblast activation following lung injury. Overall, the work suggests that PRRX1 plays a functional role downstream of TGFb1 to elicit some aspects of the fibrotic response and that PRRX1 could represent an important therapeutic target to treat fibrosis. The strengths of this work are the multiple approaches applying human and mouse lung tissue used by the authors to test the role of PRRX1 in lung fibrosis, however, in its current form, major limitations need to be addressed.

   Reviewed by eLife

9. Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration

   This article has 6 authors:

   1. Terren K Niethamer
   2. Lillian I Levin
   3. Michael P Morley
   4. Apoorva Babu
   5. Su Zhou
   6. Edward E Morrisey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study has advanced our mechanistic understanding of lung regeneration. While the importance of regeneration of alveolar capillaries for long response to injury has been long recognized, the regulation of this process has not been well understood. Your study provides novel, comprehensive, and compelling evidence that the expression of the transcription factor Atf3 in alveolar capillary endothelial cells plays a critical role in the regeneration of alveolar capillaries following lung injury.

   Reviewed by eLife

10. Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

    This article has 23 authors:

    1. Qinyu Hao
    2. Minxue Liu
    3. Swapna Vidhur Daulatabad
    4. Saba Gaffari
    5. You Jin Song
    6. Rajneesh Srivastava
    7. Shivang Bhaskar
    8. Anurupa Moitra
    9. Hazel Mangan
    10. Elizabeth Tseng
    11. Rachel B Gilmore
    12. Susan M Frier
    13. Xin Chen
    14. Chengliang Wang
    15. Sui Huang
    16. Stormy Chamberlain
    17. Hong Jin
    18. Jonas Korlach
    19. Brian McStay
    20. Saurabh Sinha
    21. Sarath Chandra Janga
    22. Supriya G Prasanth
    23. Kannanganattu V Prasanth

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study concerns an important area, that of monoallelic expression, but the study does not provide sufficient information about the candidate regulatory RNA to provide a significant advance over previous work, which should also be discussed in more detail.

    Reviewed by eLife