eLife

Latest preprint reviews

1. Imaging microglia surveillance during sleep-wake cycles in freely behaving mice

   This article has 12 authors:

   1. Xiaochun Gu
   2. Zhong Zhao
   3. Xueli Chen
   4. Lifeng Zhang
   5. Huaqiang Fang
   6. Ting Zhao
   7. Shenghong Ju
   8. Weizheng Gao
   9. Xiaoyu Qian
   10. Xianhua Wang
   11. Jue Zhang
   12. Heping Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses cutting-edge miniature two-photon microscopy to follow the structural dynamics of microglia in the somatosensory cortex of freely-moving mice across the sleep/wake cycle. Solid evidence revealed the brain-state-dependent regulation of microglial activity, highlighting alterations in microglial morphology during REM and NREM sleep phases compared to wakefulness. Furthermore, this study provides evidence for a critical role of norepinephrine from the locus coeruleus as a modulator of microglial morphology through the β2-adrenergic receptor (b2AR). Overall, the article is an impressive technical feat to bridge a crucial gap in understanding sleep state-induced dynamics of microglia and its modulation by norepinephrine signaling.

   Reviewed by eLife

2. Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer

   This article has 11 authors:

   1. José Manuel García-Martínez
   2. Ana Chocarro-Calvo
   3. Javier Martínez-Useros
   4. María Jesús Fernández-Aceñero
   5. M Carmen Fiuza
   6. José Cáceres-Rentero
   7. Antonio De la Vieja
   8. Antonio Barbáchano
   9. Alberto Muñoz
   10. María Jesús Larriba
   11. Custodia García-Jiménez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study demonstrates that vitamin D-bound VDR increased the expression of SIRT1 and that vitamin D-bound VDR interacts with SIRT1 to cause auto-deacetylation on Lys610 and activation of SIRT1 catalytic activity. This is an important finding that is relevant to the actions of VDR on colorectal cancer. The data presented to support the presented conclusion are convincing.

   Reviewed by eLife

3. A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

   This article has 8 authors:

   1. Jiamin Lin
   2. Pingping Zhang
   3. Wei Liu
   4. Guorong Liu
   5. Juan Zhang
   6. Min Yan
   7. Yuyou Duan
   8. Na Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a valuable finding on the mechanistic connections between epithelial-mesenchymal transition (EMT) and lipid metabolism. The authors identified the ZEB2/ACSL4 axis as a newly discovered metastatic metabolic pathway that promotes both lipogenesis and fatty acid oxidation. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on cancer.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2022.01.31.478462

5. We couldn't get details of this article at this time:
   10.1101/2023.01.20.524891

6. The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

   This article has 6 authors:

   1. Lina Sagert
   2. Christian Winter
   3. Ina Ruppert
   4. Maximilian Zehetmaier
   5. Christoph Thomas
   6. Robert Tampé

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study reports a complete in vitro system where different steps and direct interactions between different components of MHCI maturation can be monitored, hence leading to a better mechanistic understanding of MHC I maturation. The evidence supporting the findings is currently incomplete and would benefit from clarification of some key issues. This work will be of interest to immunologists and biochemists.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.02.22.529580

8. We couldn't get details of this article at this time:
   10.1101/2023.02.19.529115

9. Higher social tolerance is associated with more complex facial behavior in macaques

   This article has 7 authors:

   1. Alan V Rincon
   2. Bridget M Waller
   3. Julie Duboscq
   4. Alexander Mielke
   5. Claire Pérez
   6. Peter R Clark
   7. Jérôme Micheletta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study shows important evidence of the correlation between social tolerance and communicative complexity in a comparison of three macaque species. Notably, the authors use an innovative, detailed methodology for quantifying facial expressions during social interactions. The results are convincing regarding a positive association between social complexity and facial behaviour, which should stimulate further comparative research in this field.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2023.02.27.530352