Latest preprint reviews

  1. Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

    This article has 8 authors:
    1. Sehrish Javed
    2. Ya-Ting Chang
    3. Yoobin Cho
    4. Yu-Ju Lee
    5. Hao-Cheng Chang
    6. Minza Haque
    7. Yu Cheng Lin
    8. Wei-Hsiang Huang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study informs whether diminishing BDNF expression or alterations in the activity of BDNF-containing neurons in the paraventricular nucleus of the hypothalamus contributes to metabolic alterations in individuals with reduced RAI1 function, including those afflicted with Smith-Magenis syndrome (SMS). The evidence supporting the conclusions is compelling in that RAI1 deficits in BDNF-containing neurons partly contribute, with prominent effects on glycemic control and modest effects on feeding and body weight regulation. This study would be of interest to neuroscientists and medical biologists working on metabolic disorders such as obesity and diabetes, as the findings in this study further links SMS-associated obesity with reduced Bdnf gene expression in the PVH and shed light on the role of the Rai1 gene in the PVH Bdnf neurons and offer a basis for future therapeutic strategies for managing obesity in SMS.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  2. Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

    This article has 6 authors:
    1. Tao Zhang
    2. Liyang Wan
    3. Han Xiao
    4. Linfeng Wang
    5. Jianzhong Hu
    6. Hongbin Lu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper represents a valuable single-cell level analysis of tendon enthesis development. It will allow further understanding of this specific process with clinical implications. Specifically, the authors provided convincing evidence for the heterogeneity of postnatal enthesis growth and the molecular dynamics and signaling networks during enthesis formation.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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