eLife

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1. Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

   This article has 115 authors:

   1. Megan E Carey
   2. Zoe A Dyson
   3. Danielle J Ingle
   4. Afreenish Amir
   5. Mabel K Aworh
   6. Marie Anne Chattaway
   7. Ka Lip Chew
   8. John A Crump
   9. Nicholas A Feasey
   10. Benjamin P Howden
   11. Karen H Keddy
   12. Mailis Maes
   13. Christopher M Parry
   14. Sandra Van Puyvelde
   15. Hattie E Webb
   16. Ayorinde Oluwatobiloba Afolayan
   17. Anna P Alexander
   18. Shalini Anandan
   19. Jason R Andrews
   20. Philip M Ashton
   21. Buddha Basnyat
   22. Ashish Bavdekar
   23. Isaac I Bogoch
   24. John D Clemens
   25. Kesia Esther da Silva
   26. Anuradha De
   27. Joep de Ligt
   28. Paula Lucia Diaz Guevara
   29. Christiane Dolecek
   30. Shanta Dutta
   31. Marthie M Ehlers
   32. Louise Francois Watkins
   33. Denise O Garrett
   34. Gauri Godbole
   35. Melita A Gordon
   36. Andrew R Greenhill
   37. Chelsey Griffin
   38. Madhu Gupta
   39. Rene S Hendriksen
   40. Robert S Heyderman
   41. Yogesh Hooda
   42. Juan Carlos Hormazabal
   43. Odion O Ikhimiukor
   44. Junaid Iqbal
   45. Jobin John Jacob
   46. Claire Jenkins
   47. Dasaratha Ramaiah Jinka
   48. Jacob John
   49. Gagandeep Kang
   50. Abdoulie Kanteh
   51. Arti Kapil
   52. Abhilasha Karkey
   53. Samuel Kariuki
   54. Robert A Kingsley
   55. Roshine Mary Koshy
   56. AC Lauer
   57. Myron M Levine
   58. Ravikumar Kadahalli Lingegowda
   59. Stephen P Luby
   60. Grant Austin Mackenzie
   61. Tapfumanei Mashe
   62. Chisomo Msefula
   63. Ankur Mutreja
   64. Geetha Nagaraj
   65. Savitha Nagaraj
   66. Satheesh Nair
   67. Take K Naseri
   68. Susana Nimarota-Brown
   69. Elisabeth Njamkepo
   70. Iruka N Okeke
   71. Sulochana Putli Bai Perumal
   72. Andrew J Pollard
   73. Agila Kumari Pragasam
   74. Firdausi Qadri
   75. Farah N Qamar
   76. Sadia Isfat Ara Rahman
   77. Savitra Devi Rambocus
   78. David A Rasko
   79. Pallab Ray
   80. Roy Robins-Browne
   81. Temsunaro Rongsen-Chandola
   82. Jean Pierre Rutanga
   83. Samir K Saha
   84. Senjuti Saha
   85. Karnika Saigal
   86. Mohammad Saiful Islam Sajib
   87. Jessica C Seidman
   88. Jivan Shakya
   89. Varun Shamanna
   90. Jayanthi Shastri
   91. Rajeev Shrestha
   92. Sonia Sia
   93. Michael J Sikorski
   94. Ashita Singh
   95. Anthony M Smith
   96. Kaitlin A Tagg
   97. Dipesh Tamrakar
   98. Arif Mohammed Tanmoy
   99. Maria Thomas
   100. Mathew S Thomas
   101. Robert Thomsen
   102. Nicholas R Thomson
   103. Siaosi Tupua
   104. Krista Vaidya
   105. Mary Valcanis
   106. Balaji Veeraraghavan
   107. François-Xavier Weill
   108. Jackie Wright
   109. Gordon Dougan
   110. Silvia Argimón
   111. Jacqueline A Keane
   112. David M Aanensen
   113. Stephen Baker
   114. Kathryn E Holt
   115. Global Typhoid Genomics Consortium Group Authorship

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Although largely descriptive, this meta-analysis of 13,000 published Typhi genomes is hugely important to public health. The dataset and presented analysis represents the first wholesale analysis of all available Typhi genomes from the last 21 years. The findings are of great significance to tracking the emergence and maintenance of AMR in Typhi and include novel insights into XDR strain emergence in Pakistan as well as the relationship between MDR maintenance and chromosomal integration.

   Reviewed by eLife

2. How enhancers regulate wavelike gene expression patterns

   This article has 9 authors:

   1. Christine Mau
   2. Heike Rudolf
   3. Frederic Strobl
   4. Benjamin Schmid
   5. Timo Regensburger
   6. Ralf Palmisano
   7. Ernst HK Stelzer
   8. Leila Taher
   9. Ezzat El-Sherif

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors describe a sophisticated method to follow enhancer activity in both live embryos and fixed embryos in Tribolium and present important data about the function of a number of enhancers in early development. They show that some of the enhancers are "dynamic" and others are "static" and use this to provide support for the "enhancer-switching" model of gene regulation suggested by some of these authors in the past. However, the evidence they provide is incomplete and although it is consistent with the model, it does not directly support it.

   Reviewed by eLife

3. Plant secondary metabolite-dependent plant-soil feedbacks can improve crop yield in the field

   This article has 11 authors:

   1. Valentin Gfeller
   2. Jan Waelchli
   3. Stephanie Pfister
   4. Gabriel Deslandes-Hérold
   5. Fabio Mascher
   6. Gaetan Glauser
   7. Yvo Aeby
   8. Adrien Mestrot
   9. Christelle AM Robert
   10. Klaus Schlaeppi
   11. Matthias Erb

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents findings that are important for understanding plant-soil feedbacks in agriculture. The authors use a large-scale agricultural field experiment to demonstrate the role of root-emitted secondary metabolites in enhancing the yield of the next crop. By using a benzoxazinoid-deficient maize genotype, the authors provide compelling evidence that biomass production and grain yield of several wheat varieties can be increased when grown in soil conditioned by maize plants able to release benzoxazinoids.

   Reviewed by eLife

4. Agonist efficiency links binding and gating in a nicotinic receptor

   This article has 2 authors:

   1. Dinesh C Indurthi
   2. Anthony Auerbach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work investigates the fundamental concept of how the energy of agonist binding is converted into the energy of the conformational change that opens the pore of a ligand-gated ion channel. The conclusions are based on analysis of solid data in terms of a mechanistic model, but adequate statistical analysis is lacking and the uniqueness of the proposed model is not discussed. The findings will be interesting to biophysicists working on ligand-gated ion channels and, more generally, to enzymologists focused on allosteric enzyme regulation.

   Reviewed by eLife

5. Large-scale neural dynamics in a shared low-dimensional state space reflect cognitive and attentional dynamics

   This article has 3 authors:

   1. Hayoung Song
   2. Won Mok Shim
   3. Monica D Rosenberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study examines the distribution of four states of brain activity across a variety of cognitive conditions, linking systems neuroscience with cognition and behavior. The work is convincing, using null models and replication in independent datasets to support their findings.

   Reviewed by eLife

6. Low-level repressive histone marks fine-tune gene transcription in neural stem cells

   This article has 9 authors:

   1. Arjun Rajan
   2. Lucas Anhezini
   3. Noemi Rives-Quinto
   4. Jay Y Chhabra
   5. Megan C Neville
   6. Elizabeth D Larson
   7. Stephen F Goodwin
   8. Melissa M Harrison
   9. Cheng-Yu Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work shows how a transcription factor, fruitless isoform C, fine-tunes the expression of stemness genes to maintain proper stem-cell identity during neurogenesis in Drosophila. The rationale of the work is well-thought-out, conclusions are supported by compelling evidence, and experiments are performed in a rigorous manner, although additional statistics would improve the conclusions. Overall, this work will be of interest to those working on chromatin regulation, transcription regulation, and stem-cell biology.

   Reviewed by eLife

7. Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’

   This article has 2 authors:

   1. Blanca Jimeno
   2. Simon Verhulst

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents a fundamental meta-analysis on the causes of glucocorticoid variations in birds and mammals. It provides convincing evidence that an increase in metabolic rates increases glucocorticoid concentrations. The work will be of broad interest to animal physiologists.

   Reviewed by eLife

8. A dual function of the IDA peptide in regulating cell separation and modulating plant immunity at the molecular level

   This article has 6 authors:

   1. Vilde Olsson Lalun
   2. Maike Breiden
   3. Sergio Galindo-Trigo
   4. Elwira Smakowska-Luzan
   5. Rüdiger GW Simon
   6. Melinka A Butenko

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents valuable findings on the role of a plant peptide in coordinating developmental and immune responses signaling. The evidence supporting the claims, while mainly descriptive and and somewhat limited due to the main conclusions being drawn from overexpression lines, is mostly solid. The findings are interesting, they align with existing models, and they are of relevance to plant pathologists and developmental biologists.

   Reviewed by eLife

9. Structure of the Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase from the model microalga Chlamydomonas reinhardtii

   This article has 7 authors:

   1. Théo Le Moigne
   2. Martina Santoni
   3. Lucile Jomat
   4. Stéphane D Lemaire
   5. Mirko Zaffagnini
   6. Nicolas Chéron
   7. Julien Henri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable structural analysis of the Sedoheptulose-1,7-Bisphosphatase (SBPase) from Chlamydomonas reinhardtii. The data presented are solid and based on X-ray structures of the CrSBPase in an oxidized and reduced state, the authors identify a disulfide bond in close proximity to the dimer interface. They show that the redox-state of the CrSBPase impacts its oligomeric state and might also influence the activity of the protein.

   Reviewed by eLife

10. Energetics of the microsporidian polar tube invasion machinery

    This article has 7 authors:

    1. Ray Chang
    2. Ari Davydov
    3. Pattana Jaroenlak
    4. Breane Budaitis
    5. Damian C Ekiert
    6. Gira Bhabha
    7. Manu Prakash

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study combines experiments and fluid mechanics modeling to determine the mechanism of the ultrafast ejection of the polar tube of the Microsporidia parasite and of transport through this tube. The methods and the analysis, based on the variation of the viscosity of the external medium, are compelling and allow for the first time to discriminate among proposed ejection mechanisms. This approach where simple physical principles are used for distinguishing between mechanisms when the precise geometry is inaccessible through imaging is potentially applicable to other systems in microbiology.

    Reviewed by eLife