eLife

Latest preprint reviews

1. Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus

   This article has 8 authors:

   1. René Lemcke
   2. Christine Egebjerg
   3. Nicolai T Berendtsen
   4. Kristoffer L Egerod
   5. Allan R Thomsen
   6. Tune H Pers
   7. Jan P Christensen
   8. Birgitte R Kornum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines experiments and computational approaches to understand the effects of influenza H1N1 infection on hypothalamic cells. The methodology and analysis are solid and raise questions around how a respiratory virus affects the central nervous system.

   Reviewed by eLife

2. A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

   This article has 5 authors:

   1. Hannah Jones
   2. Jenny A Willis
   3. Lucy C Firth
   4. Carlo NG Giachello
   5. Giorgio F Gilestro

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important open-source resource for high-throughput behavioral screening. The protocols employ inexpensive, off the shelf hardware, and allow real-time analysis of hundreds of behaving flies. Although these protocols were developed using Drosophila melanogaster, they could easily be applied to other models. The evidence in support of the conclusions is solid and the revisions carried out by the authors go a long way towards providing the user with an integrated system that is also more user-friendly.

   Reviewed by eLife

3. Adaptive biasing of action-selective cortical build-up activity by stimulus history

   This article has 2 authors:

   1. Anke Braun
   2. Tobias H Donner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In uncertain conditions, decisions are not made in isolation but are rather biased by the recent past. This new work provides valuable insights into these history biases in human perceptual decision-making, by characterizing the neural correlates of stimulus history biases and their short-term dynamics. The study provides compelling behavioral and MEG evidence that humans adapt their history biases to the correlation structure of uncertain sensory environments.

   Reviewed by eLife

4. A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

   This article has 13 authors:

   1. Chaojun Yan
   2. Jingjing Xiong
   3. Zirui Zhou
   4. Qifang Li
   5. Chuan Gao
   6. Mengyao Zhang
   7. Liya Yu
   8. Jinpeng Li
   9. Ming-Ming Hu
   10. Chen-Song Zhang
   11. Cheguo Cai
   12. Haojian Zhang
   13. Jing Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents the valuable finding that a cleaved form of METTL3 (termed METTL3a) has an essential role in regulating the assembly of the METTL3-METTL14-WTAP complex. The evidence supporting the claims of the authors is solid, and the work will be of interest to medical biologists working on breast cancer.

   Reviewed by eLife

5. Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

   This article has 13 authors:

   1. Stewart WC Masson
   2. Søren Madsen
   3. Kristen C Cooke
   4. Meg Potter
   5. Alexis Diaz Vegas
   6. Luke Carroll
   7. Senthil Thillainadesan
   8. Harry B Cutler
   9. Ken R Walder
   10. Gregory J Cooney
   11. Grant Morahan
   12. Jacqueline Stöckli
   13. David E James

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study leverages natural genetic diversity in mice to discover candidate genes for insulin sensitivity, followed by experimental identification of compounds that can modulate insulin sensitivity, and finally initial mechanistic investigation of the mode of action. The generalized approach presented here – the integration of systems genetics data with drug discovery – supported by compelling evidence, will be a guide for others who seek to translate insights from mammalian genetics to drug discovery.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.02.17.528915

7. Different rules for binocular combination of luminance flicker in cortical and subcortical pathways

   This article has 6 authors:

   1. Federico G Segala
   2. Aurelio Bruno
   3. Joel T Martin
   4. Myat T Aung
   5. Alex R Wade
   6. Daniel H Baker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides potentially important, new insights about the combination of information from the two eyes in humans. The data includes frequency tagging of each eye's inputs and measures reflecting both cortical (EEG) and sub-cortical processes (pupillometry). The strength of supporting evidence is solid, suggesting that temporal modulations are combined differently than spatial modulations, with additional differences between subcortical and cortical pathways. However, questions remain as to exactly how information is combined, how the findings relate to the extant literature and more broadly, to the interests of vision scientists at large.

   Reviewed by eLife

8. The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation

   This article has 9 authors:

   1. Ida L Barlow
   2. Eirinn Mackay
   3. Emily Wheater
   4. Aimee Goel
   5. Sumi Lim
   6. Steve Zimmerman
   7. Ian Woods
   8. David A Prober
   9. Jason Rihel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This study offers new fundamental information on a role for the sodium/potassium pump in sleep regulation. Elegant methods were used to provide compelling evidence supporting the claim. The work will be of interest to sleep researchers in zebrafish as well as in other species for future investigation.

   Reviewed by eLife

9. Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions

   This article has 13 authors:

   1. Dániel Veréb
   2. Mite Mijalkov
   3. Anna Canal-Garcia
   4. Yu-Wei Chang
   5. Emiliano Gomez-Ruiz
   6. Blanca Zufiria Gerboles
   7. Miia Kivipelto
   8. Per Svenningsson
   9. Henrik Zetterberg
   10. Giovanni Volpe
   11. Matthew Betts
   12. Heidi IL Jacobs
   13. Joana B Pereira

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides fundamental imaging evidence from two independent functional imaging datasets, for a rostral-caudal gradient of locus coeruleus connectivity, which changes across the lifespan. The gradient approach is well-established and convincing results were obtained and validated using large 3T and 7T fMRI datasets. This work will be of interest to clinical and cognitive neuroscientists.

   Reviewed by eLife

10. Dorsolateral prefrontal activity supports a cognitive space organization of cognitive control

    This article has 6 authors:

    1. Guochun Yang
    2. Haiyan Wu
    3. Qi Li
    4. Xun Liu
    5. Zhongzheng Fu
    6. Jiefeng Jiang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Yang et al. investigate whether distinct sources of conflict are represented in a common cognitive space. The study uses an interesting task that mixes different sources of difficulty and reports that the brain appears to represent these sources as a mixture on a continuum in prefrontal areas. While the findings could be valuable to theory in this area, there are some concerns with the design and results, that raise uncertainty regarding the main conclusion of a shared cognitive space. The authors appropriately acknowledge these limitations while also highlighting the valid contributions that the study makes. Thus, while solid evidence is reported here, consistent with the central hypothesis, further experiments are required to support the strictest interpretation.

    Reviewed by eLife