eLife

Latest preprint reviews

1. Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

   This article has 20 authors:

   1. Akihiro Miura
   2. Hemanta Sarmah
   3. Junichi Tanaka
   4. Youngmin Hwang
   5. Anri Sawada
   6. Yuko Shimamura
   7. Takehiro Otoshi
   8. Yuri Kondo
   9. Yinshan Fang
   10. Dai Shimizu
   11. Zurab Ninish
   12. Jake Le Suer
   13. Nicole C Dubois
   14. Jennifer Davis
   15. Shinichi Toyooka
   16. Jun Wu
   17. Jianwen Que
   18. Finn J Hawkins
   19. Chyuan-Sheng Lin
   20. Munemasa Mori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This current study provides a new model of lung agenesis to explore the generation of the ability of blastocyst complementation to generate an entire organ. These studies will provide new avenues for organ bioengineering and additional insight into early contribution of mesoendoderm to lung development.

   Reviewed by eLife

2. SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury

   This article has 11 authors:

   1. Xiaoyan Yang
   2. Hsiang-Chun Chang
   3. Yuki Tatekoshi
   4. Amir Mahmoodzadeh
   5. Maryam Balibegloo
   6. Zeinab Najafi
   7. Rongxue Wu
   8. Chunlei Chen
   9. Tatsuya Sato
   10. Jason Shapiro
   11. Hossein Ardehali

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, Yang et al. have shown that SIRT2 has adverse effects on the heart in response to injury. Further, they demonstrate that deletion of Sirt2 is protective through stabilization and increased nuclear translocation of NRF2, which leads to increased expression of antioxidant genes. They also show that pharmacological inhibition of SIRT2 protects the heart against the development of cardiac hypertrophy.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2022.08.25.505283

4. Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels

   This article has 12 authors:

   1. Jinping Lu
   2. Ingo Dreyer
   3. Miles Sasha Dickinson
   4. Sabine Panzer
   5. Dawid Jaślan
   6. Carlos Navarro-Retamal
   7. Dietmar Geiger
   8. Ulrich Terpitz
   9. Dirk Becker
   10. Robert M Stroud
   11. Irene Marten
   12. Rainer Hedrich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Plant intracellular ion channels are poorly understood. In this important manuscript, patch-clamp is used to define functional differences between two cation channels present in the vacuole of different plants. The authors find a calcium-biding site whose absence or presence modulate activation at lower voltages and is responsible for increased excitability in the vacuole of the faba bean plant. The experimental evidence presented is convincing and findings have practical implications for the field of plant electrophysiology and channel biophysics.

   Reviewed by eLife

5. Commensal bacteria maintain a Qa-1b-restricted unconventional CD8+ T population in gut epithelium

   This article has 6 authors:

   1. Jian Guan
   2. J David Peske
   3. Michael Manoharan Valerio
   4. Chansu Park
   5. Ellen A Robey
   6. Scheherazade Sadegh-Nasseri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that investigates the role of commensal microbes and molecules in the antigen presentation pathway affecting the development and phenotype of an unusual population of T lymphocytes. The authors provide compelling evidence to identify a population of unconventional T cells that exist in the small intestinal epithelium, which appear to depend on commensal microbes, and show that a single commensal microbe (that encodes an antigen capable of weakly stimulating these cells) is sufficient to maintain this T cell population.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.06.23.546221

7. We couldn't get details of this article at this time:
   10.1101/2023.07.18.549452

8. We couldn't get details of this article at this time:
   10.1101/2023.05.15.540820

9. We couldn't get details of this article at this time:
   10.1101/2023.05.04.539433

10. We couldn't get details of this article at this time:
    10.1101/2023.05.02.539064